Title:
ＳＵＭＯ抑制剤を含有する抗肝線維症のための組成物および使用
Document Type and Number:
Japanese Patent JP7121415
Kind Code:
B2
Abstract:
The present invention provides a composition containing SUMO inhibitor, and belongs to the technical field of medicine. The composition includes FXR agonist and SUMO inhibitor. In activated hepatic stellate cells, the FXR agonist does not have an effect in inhibiting the activation of hepatic stellate cells. After the FXR agonist and the SUMO inhibitor are compounded according to the present invention, the activation of hepatic stellate cells can also be inhibited for those cells under activated state. Of note, the hepatic stellate cells of an individual with hepatic fibrosis symptoms have been in an activated state, therefore a good anti-fibrotic effect cannot be achieved by using the FXR agonist alone. The composition of FXR agonist and SUMO inhibitor proposed by the present invention can significantly inhibit the activation of hepatic stellate cells under activated state, thus significantly reducing the deposition of collagen fibers and alleviating liver fibrosis.
Inventors:
▲ハオ▼ 海平
Wang Hong
Zhou Ji-woo
Hiroki Wang
Choi Sang
Ban Hyojie
郭 怡▲トン▼
Ningning Huang
Wang Hong
Zhou Ji-woo
Hiroki Wang
Choi Sang
Ban Hyojie
郭 怡▲トン▼
Ningning Huang
Application Number:
JP2020539275A
Publication Date:
August 18, 2022
Filing Date:
November 22, 2019
Export Citation:
Assignee:
CHINA PHARMACEUTICAL UNIVERSITY
International Classes:
A61K31/42; A61K31/357; A61K31/55; A61K31/575; A61K31/60; A61P1/16; A61P29/00; A61P43/00
Domestic Patent References:
| JP2018514534A |
Foreign References:
| CN108114284A | ||||
| CN106974916A |
Attorney, Agent or Firm:
Kimura Mitsuru
Yasushi Morikawa
Kei Sakurada
Hideki Mie
Yasushi Morikawa
Kei Sakurada
Hideki Mie
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