Title:
遺伝子編集効率を調節するための化合物およびその使用
Document Type and Number:
Japanese Patent JP7370524
Kind Code:
B2
Abstract:
A compound for improving the gene editing specificity and application thereof. Specifically disclosed is a compound represented by formula I or a use of a pharmaceutically acceptable salt thereof. The compound and the pharmaceutically acceptable salt thereof are used for preparing an inhibitor, a composition, or a formulation for inhibiting gene editing and/or improving the gene editing specificity. The structure of the formula I is as stated in the description. The compound can significantly improve the accuracy of CRISPR gene editing, thereby providing a simple and high-efficient policy for accurate gene editing.
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Inventors:
Riu, Zia
Don, The Asia
Don, The Asia
Application Number:
JP2021518841A
Publication Date:
October 30, 2023
Filing Date:
June 13, 2019
Export Citation:
Assignee:
SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES
SHANGHAITECH UNIVERSITY
SHANGHAITECH UNIVERSITY
International Classes:
C12N15/09; A61K31/4196; A61K31/4439; A61K31/497; A61K31/506; A61P43/00; C07D249/08
Other References:
YAMANO T et al.,“Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA.”,Cell,2016年04月21日,Vol. 165, No. 4,p.949-62
Genome Medicine,2015年,Vol.7, No.93,P.1-11
Chemistry & Biology,2015年,Vol.22,p.107-116
Genome Medicine,2015年,Vol.7, No.93,P.1-11
Chemistry & Biology,2015年,Vol.22,p.107-116
Attorney, Agent or Firm:
Kiyoshi Kuzuwa