NEW MATERIAL:A dibenzoxazepine derivative of formula I: (R1 is H, 1W2 halogens, lower alkyl, or lower alkoxy group; R2 is hydroxyl, lower alkoxy, or anilino group; R3 is H or acyl group).
EXAMPLE: 10, 11-Dihydro-4-methoxy-dibenzo (b, f) (1, 4)-oxazepine-8-carboxylic ethyl ester.
USE: Useful as medicines having a decholesterolization effect.
PROCESS: A diphenyl ether derivative of formula II: (R4 is lower alkyl group) is reduced and subjected to ring closure, to form a compound of formula III in the compound of formula I (R2 is lower alkoxy; R3 is H). The compound of formula III is then hydrolyzed to give a compound of formula IV, which is reacted with a (nuclear substituted) aniline to afford a compound of formula V: (R5 is H, etc.) of the formula I: [R2 is nuclear substituted anilino group; R3 is H].
SASAHARA KAZUO
MURAKAMI YASUSHI
WADA SAKAE
NAKAKIMURA HIROSHI
KUBODERA NOBORU
HATA SHIYUNICHI
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