Title:
DRUG HAVING SYNERGISTIC ANTIFUNGAL ACTIVITY AND ANTIVIRAL ACTIVITY
Document Type and Number:
Japanese Patent JPH02115125
Kind Code:
A
Abstract:
PURPOSE: To obtain a medicament having synergistic antimycotic activity including a cyclopirox (derivative) and a nigericin (derivative). CONSTITUTION: This medicament having synergistic antimycotic activity includes (A) a compound of formula I (R<1> is H, an alkyl or a cycloalkyl; R<2> is H or an alkyl) or a salt thereof, e.g. an ethanolamine salt of 6-cyclohexyl-1hydroxy-4 methyl-2(1H)-pyridone and (B) a compound of formulas II to V [A<1> is H or an alkyl; A<2> is H, C(O)A<3> , C(O)NHA<3> (A<3> is an alkyl, phenyl, etc.), etc.; X is a halogen, SCN, CN, NO2 , etc.; M<1> is H, an alkyl, phenyl, etc.; M<2> is H, an alkyl or a cycloalkylphenyl; M<3> is OH or both of M<3> and M<2> represent O)] or a salt thereof so that the ratio of components A to B may be (1:9) to (9:1), preferably (1:5) to (5:1). The divided dose in terms of the total of components A and B is 10-50mg.
Inventors:
GEERUHARUTO ZAIBERUTO
BUORUFUGANGU RAETAA
IRUBUIN BUINKURAA
PEETAA HAMAN
YOOAHIMU BUINKU
BUORUFUGANGU RAETAA
IRUBUIN BUINKURAA
PEETAA HAMAN
YOOAHIMU BUINKU
Application Number:
JP23054689A
Publication Date:
April 27, 1990
Filing Date:
September 07, 1989
Export Citation:
Assignee:
HOECHST AG
International Classes:
A61K31/35; A61K31/41; A61K31/44; A61K31/495; A61K31/695; A61P31/04; A61P31/10; A61P31/12; (IPC1-7): A61K31/35; A61K31/44
Attorney, Agent or Firm:
Chika Takagi (2 outside)