PURPOSE: To obtain a drug preparation for transcutaneous absorption having the stability as well as good transcutaneous absorbability of nicorandil by uniformly dispersing nicorandil in a base agent in the form of fine crystal particles having specific particle diameter and compounding a specific stabilizer thereto.
CONSTITUTION: One to 20wt.% of N-(2-hydroxyethyl)nicotinamide nitrate (nicorandil) having antistenocardiac action is uniformly dispersed in a base agent in the form of fine crystal particles mostly having an average particle diameter of ≥2μm, preferably ≥4μm and the dispersion is compounded with 0.5-20wt.% (preferably 1-10wt.%) of a stabilizer consisting of an organic acid metal salt composed of univalent and/or bivalent metals and an organic acid and, preferably, 1-20wt.% of an absorbefacient. Nicorandil of isolated state can be extremely highly stabilized to enable the selection range of the absorbefacient to be used in combination. An acrylic base agent can be used in the preparation.
KAMINOYAMA TOMOHITO
IZUMOTO TANEYA
SOGA WAKAKO
CHUGAI PHARMACEUTICAL CO LTD
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