Title:
ENDOPLASMIC RETICULUM TARGETED NANOVEHICLE AND METHOD OF USING THE SAME
Document Type and Number:
Japanese Patent JP2019182834
Kind Code:
A
Abstract:
To provide methods for treating diseases caused by protein retention in endoplasmic reticulum.SOLUTION: Provided is a method comprising obtaining a sarcoplasmic reticulum/endoplasmic reticulum calcium ATPase (SERCA) pump inhibitor encapsulated in a polymer nanoparticle, and administering to a subject an effective amount of the inhibitor, the polymer nanoparticle being surface modified to target the endoplasmic reticulum (ER), the effective amount of the inhibitor reducing protein retention in ER, the side effects of the inhibitor being reduced by encapsulation as compared to administration of the inhibitor without encapsulation.SELECTED DRAWING: None
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Inventors:
SHIEH CHI-CHANG
YEN CHIA-LIANG
SHIEH DAR-BIN
JIANG SI-TSE
YEN CHIA-LIANG
SHIEH DAR-BIN
JIANG SI-TSE
Application Number:
JP2019022300A
Publication Date:
October 24, 2019
Filing Date:
February 12, 2019
Export Citation:
Assignee:
UNIV NAT CHENG KUNG
International Classes:
A61K45/00; A01K67/027; A61K9/51; A61K31/05; A61K31/12; A61K31/365; A61K31/407; A61K31/4375; A61K31/554; A61K31/58; A61K47/32; A61K47/34; A61K47/36; A61K47/42; A61P3/00; A61P3/06; A61P3/10; A61P5/14; A61P7/00; A61P7/04; A61P7/06; A61P9/00; A61P13/02; A61P13/12; A61P17/00; A61P19/08; A61P25/00; A61P25/28; A61P27/02; A61P31/04; A61P35/00; A61P43/00
Other References:
J IMMMUNOL, vol. 198 (1_Supplenment), JPN6023002050, 2017, pages 81 - 12, ISSN: 0004970189
NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY, AND MEDICINE, vol. 9, JPN6023002051, 2013, pages 366 - 374, ISSN: 0004970190
NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY, AND MEDICINE, vol. 9, JPN6023002051, 2013, pages 366 - 374, ISSN: 0004970190
Attorney, Agent or Firm:
Patent Business Corporation Saegusa International Patent Office