Title:
操作された転写活性化因子様エフェクター（ＴＡＬＥ）ドメインおよびその使用
Document Type and Number:
Japanese Patent JP7149599
Kind Code:
B2
Abstract:
Engineered transcriptional activator-like effectors (TALEs) are versatile tools for genome manipulation with applications in research and clinical contexts. One current drawback of TALEs is their tendency to bind and cleave off-target sequence, which hampers their clinical application and renders applications requiring high-fidelity binding unfeasible. This disclosure provides engineered TALE domains and TALEs comprising such engineered domains, e.g., TALE nucleases (TALENs), TALE transcriptional activators, TALE transcriptional repressors, and TALE epigenetic modification enzymes, with improved specificity and methods for generating and using such TALEs.
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Inventors:
Riu, David, Earl.
Gillinger, John, Paul
Pattanayak, Vikram
Gillinger, John, Paul
Pattanayak, Vikram
Application Number:
JP2019148422A
Publication Date:
October 07, 2022
Filing Date:
August 13, 2019
Export Citation:
Assignee:
President and Fellows of Harvard College
International Classes:
C07K14/00; A61K38/46; A61P31/18; A61P35/00; A61P43/00; C12N9/22; C12N15/09; C12P21/02
Domestic Patent References:
| JP2011081011A | ||||
| JP6633524B2 |
Foreign References:
| WO2012138927A2 | ||||
| WO2013047844A1 |
Other References:
Nature Biotechnology (2011) Vol.29, No.2, p.143-148, Supplementary Information, pp.1-20
PNAS (2009) Vol.106, No.15, pp.6111-6116
ウイルス (2007) Vol.57, No.2, pp.133-140
PNAS (2009) Vol.106, No.15, pp.6111-6116
ウイルス (2007) Vol.57, No.2, pp.133-140
Attorney, Agent or Firm:
Kiyokazu