Title:
エストロゲン受容体調節剤
Document Type and Number:
Japanese Patent JP4554219
Kind Code:
B2
Abstract:
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.
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Inventors:
Frank Pea, Dinino
Blizzard, Timothy Allen
Morgan, Jerry Dewine, The Second
Blizzard, Timothy Allen
Morgan, Jerry Dewine, The Second
Application Number:
JP2003587798A
Publication Date:
September 29, 2010
Filing Date:
April 18, 2003
Export Citation:
Assignee:
Merck Sharp End Dome Corporation
International Classes:
C07D327/06; A61K31/39; A61K31/4025; A61K45/00; A61P1/02; A61P3/04; A61P3/06; A61P7/12; A61P9/00; A61P9/10; A61P15/08; A61P19/02; A61P19/08; A61P19/10; A61P25/28; A61P29/00; A61P35/00; A61P35/04; A61P43/00; C07D411/12
Foreign References:
| WO1999063974A1 | ||||
| WO2002032377A1 | ||||
| WO2003087073A1 |
Other References:
Journal of Medicinal Chemistry (1990), 33(12), 3210-3216
Attorney, Agent or Firm:
Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura