アンドロゲン受容体モジュレーターとしてのフッ素付加4-アザステロイド

Japanese Patent JP2007534757

A

Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.

Robert Es Meissner
Perkins, James Aye

JP2007510821A

November 29, 2007

April 22, 2005

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MERCK & COMPANY INCOPORATED

C07J3/00; A61K31/437; A61K31/473; A61K31/568; A61K31/58; A61K31/663; A61P1/02; A61P3/02; A61P3/04; A61P3/06; A61P5/26; A61P5/30; A61P7/06; A61P9/10; A61P11/00; A61P15/10; A61P15/12; A61P19/02; A61P19/08; A61P19/10; A61P21/00; A61P21/04; A61P25/24; A61P25/28; A61P29/00; A61P31/18; A61P35/00; A61P37/06; A61P43/00; C07D401/12; C07D401/14; C07J73/00

JPH04216194A

1992-08-06

WO2003077919A1

2003-09-25

Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura

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