Title:
高度に分枝した非置換又は低置換デンプン生成物、これを含有する透析溶液及び血漿増量剤、並びにその使用
Document Type and Number:
Japanese Patent JP4594729
Kind Code:
B2
Abstract:
Known hydroxyethylated and -propylated starch types for use as colloid osmotic agent in peritoneal dialysis or as volume replacement composition (plasma expander) have the disadvantage that complete degradation by amylase is not possible owing to the more or less extensive substitution by hydroxyethyl or hydroxypropyl groups. As a consequence thereof, residual fragments remain in the body and are eliminated only very slowly or are stored in various organs/tissues, especially with relatively high and/or long-term dosage. These disadvantageous properties can be very substantially avoided according to the invention with a highly branched, unsubstituted or low-substituted starch product, i.e. with a starch which has a significantly higher degree of branching than amylopectin, and has the degree of alpha-I,6 branching of glycogen, or exceeds the latter and-if substituted-has a degree of substitution MS of only up to 0.3.
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Inventors:
Henning, kraos
Application Number:
JP2004533291A
Publication Date:
December 08, 2010
Filing Date:
July 30, 2003
Export Citation:
Assignee:
Fresenius Mold Deutschland Gamebecher
International Classes:
A61K31/718; C08B31/12; A61M1/28; A61P7/08; C08B30/20; C08B31/18; C08B35/04
Domestic Patent References:
| JP7025788A | ||||
| JP3026701A | ||||
| JP2004161998A | ||||
| JP2002543248A |
Foreign References:
| WO2003018639A1 |
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Mitsutoshi Nakamura
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Mitsutoshi Nakamura