Title:
ヒストン脱アセチル化酵素阻害剤
Document Type and Number:
Japanese Patent JP4954200
Kind Code:
B2
Abstract:
Compounds of formula: (I), and salts, N-oxides, hydrates and solvates thereof are histone deacetylase inhibitors and are useful in the treatment of cell proliferative diseases, including cancers: (I) wherein Q, V and W independently represent —N═ or —C═; B is a divalent radical selected from: (IIA), (IIB), (IIC), (IID), and (IIE). Wherein the bond marked * is linked to the ring containing Q, V and W through -[Linker1]- and the bond marked ** is linked to A through -[Linker2]-; A is an optionally substituted mono-, bi- or tri-cyclic carbocyclic or heterocyclic ring system; and -[Linker1]- and -[Linker2]- independently represent a bond, or a divalent linker radical.
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Inventors:
Moffat, David, Festus, Charles
Patel, Sanjay, Lateral
Massey, Francesca, Anne
Bellfield, Andrew, James
Van Muse, Sandra
Patel, Sanjay, Lateral
Massey, Francesca, Anne
Bellfield, Andrew, James
Van Muse, Sandra
Application Number:
JP2008511780A
Publication Date:
June 13, 2012
Filing Date:
May 15, 2006
Export Citation:
Assignee:
CHROMA THERAPEUTICS LTD
International Classes:
C07D209/52; A61K31/403; A61K31/407; A61K31/4439; A61K31/506; A61P3/10; A61P25/00; A61P29/00; A61P31/00; A61P35/00; C07D401/14; C07D403/04; C07D403/12; C07D403/14; C07D405/14; C07D409/14; C07D417/14; C07D471/10; C07D487/04
Foreign References:
| WO2003076430A1 | ||||
| WO2003076401A1 | ||||
| WO2003076422A1 | ||||
| WO2003075929A1 |
Attorney, Agent or Firm:
Shintaro Nogawa