Title:
【発明の名称】ヒト白血球12-リポキシゲナーゼ経路の形成または活性の阻害
Document Type and Number:
Japanese Patent JPH07500254
Kind Code:
A
Abstract:
The discovery and regulation of a 12-LO isoform (hl 12-LO) expressed in human tissues and of a similar isoform in PVSMCs is described. Various ribozyme and chemical inhibitors of the hl 12-LO pathway are described. The involvement of this 12-LO pathway in AII induced hypertrophy is demonstrated. It is shown that HG culture potentiates the stimulatory effects of AII and HETE in vascular smooth muscles. A specific aspect of the invention is the discovery that activation of a 12-LO pathway in vascular smooth muscle accentuates AII induced vascular hypertrophic response in diabetes mellitus. Human therapy involving mediation of the hl 12-LO pathway is described.
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Inventors:
Nadler, Jerry El
Natarajan, Rama Devi
Gu, Jari
Natarajan, Rama Devi
Gu, Jari
Application Number:
JP50734194A
Publication Date:
January 12, 1995
Filing Date:
August 26, 1993
Export Citation:
Assignee:
City of Hope
International Classes:
C12N9/04; A61K31/00; A61K31/045; A61K31/05; A61K31/155; A61K31/195; A61K31/20; A61K31/35; A61K31/44; A61K31/575; A61K38/08; A61K38/44; A61P9/00; C12N9/02; C12N9/99; C12N15/12; G01N33/573; A61K38/00; (IPC1-7): C12N9/04; A61K38/44; C12N9/99; C12N15/53
Domestic Patent References:
| JPH01101236A | 1989-04-19 |
Attorney, Agent or Firm:
Kyozo Yuasa (6 people outside)