Title:
INTERLEUKIN-10 IMMUNOCONJUGATE
Document Type and Number:
Japanese Patent JP2020089371
Kind Code:
A
Abstract:
To provide fusion proteins of antibodies and interleukin-10 (IL-10), particularly fusion proteins of antibodies and mutant IL-10 that exhibit improved properties for use as therapeutic agents for inflammatory diseases.SOLUTION: A fusion protein of an IgG-class antibody and a mutant IL-10 molecule comprises two identical heavy chain polypeptides and two identical light chain polypeptides, where the mutant IL-10 molecule comprises an amino acid mutation that reduces the binding affinity of the mutant IL-10 molecule to the IL-10 receptor compared to a wild-type IL-10 molecule.SELECTED DRAWING: Figure 1
Inventors:
THOMAS EMRICH
PABLO UMANA
MOESSNER EKKEHARD
RALF HOSSE
JENS FISCHER
LYDIA JASMIN HANISCH
XU DAIGEN
PABLO UMANA
MOESSNER EKKEHARD
RALF HOSSE
JENS FISCHER
LYDIA JASMIN HANISCH
XU DAIGEN
Application Number:
JP2020000462A
Publication Date:
June 11, 2020
Filing Date:
January 06, 2020
Export Citation:
Assignee:
HOFFMANN LA ROCHE
International Classes:
C12N15/62; A61K38/20; A61K39/395; A61K47/68; A61P1/04; A61P11/00; A61P19/02; A61P29/00; A61P37/06; C07K14/54; C07K16/18; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/13; C12N15/24; C12N15/63; C12P21/02
Attorney, Agent or Firm:
Sonoda/Kobayashi Patent Business Corporation
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