Title:
Ion exchange chromatography which raised the selectivity for separating a polypeptide monomer, a condensation thing, and fragmentation by adjustment of the mobile phase
Document Type and Number:
Japanese Patent JP5984854
Kind Code:
B2
Abstract:
Herein is reported a method for producing a polypeptide in monomeric form comprising the following step: recovering the polypeptide in monomeric form from an ion exchange chromatography material by applying a solution comprising a nonionic polymer and an additive.
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Inventors:
Newman Sebastian
Application Number:
JP2013558420A
Publication Date:
September 06, 2016
Filing Date:
March 14, 2012
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07K1/18; C07K16/00; C12P21/08
Domestic Patent References:
| JP2008542218A | ||||
| JP2002517516A |
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
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