Title:
MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
Document Type and Number:
Japanese Patent JP2018104437
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide macrocyclic compounds useful as anti-infective, antiproliferative, anti-inflammatory and prokinetic agents, and synthesis methods therefor.SOLUTION: The present invention provides a compound of the following formula, or a pharmaceutically acceptable salt, ester, N-oxide, or prodrug there(T is a 14-, 15-, or 16-membered macrolide, Rand Rare independently H, a C1-6 alkyl, a C2-6 alkenyl or the like, Ris H or -OR, Ris H, a C1-6 alkyl, a C2-6 alkenyl or the like, D and F are independently a single bond, a C1-6 alkyl, a C2-6 alkenyl or the like, E is a 3-10 membered saturated, unsaturated, or aromatic heterocycle or the like, G is B' and B'-Z-B", where B' and B" are independently aryl, heteroaryl, or biaryl).SELECTED DRAWING: None
Inventors:
JAY J FARMER
BHATTACHARJEE ASHOKE
CHEN YI
GOLDBERG JOEL A
IPPOLITO JOSEPH A
KANYO ZOLTAN F
LOU RONGLIANG
ADEGBOYEGA K OYELERE
EDWARD C SHERER
SUTCLIFFE JOYCE A
WANG DEPING
WU YUSHENG
DU YANMING
BHATTACHARJEE ASHOKE
CHEN YI
GOLDBERG JOEL A
IPPOLITO JOSEPH A
KANYO ZOLTAN F
LOU RONGLIANG
ADEGBOYEGA K OYELERE
EDWARD C SHERER
SUTCLIFFE JOYCE A
WANG DEPING
WU YUSHENG
DU YANMING
Application Number:
JP2018009418A
Publication Date:
July 05, 2018
Filing Date:
January 24, 2018
Export Citation:
Assignee:
MELINTA SUBSIDIARY CORP
International Classes:
C07H17/00; A61K31/7048; A61K31/7052; A61K31/7056; A61K31/706; A61P1/04; A61P1/10; A61P1/14; A61P29/00; A61P31/00; A61P31/04; A61P31/10; A61P31/12; A61P33/00; A61P35/00; C07H17/08
Foreign References:
| WO2004013153A2 | 2004-02-12 | |||
| WO2000040589A2 | 2000-07-13 | |||
| WO1999022722A2 | 1999-05-14 | |||
| WO1999016779A1 | 1999-04-08 | |||
| WO2002051855A2 | 2002-07-04 |
Attorney, Agent or Firm:
Kawaguchi International Patent Office