Title:
MACROCYCLIC PEPTIDE, PRODUCTION METHOD THEREOF, AND SCREENING METHOD USING MACROCYCLIC PEPTIDE LIBRARY
Document Type and Number:
Japanese Patent JP2015042159
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a peptide which is sufficiently excellent in tolerance to metabolism, has a stable structure in vivo, and can penetrate a cell membrane to reach a cell.SOLUTION: The invention provides a macrocyclic peptide in which four or more amino acids form a macrocyclic structure, wherein at least two amino acids which are not adjacent each other have hydrophobic side chains, and in hydrophilic environment, the hydrophobic side chains interact with each other in the inside of the ring of the macrocyclic peptide.
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Inventors:
SUGA HIROAKI
Application Number:
JP2013174906A
Publication Date:
March 05, 2015
Filing Date:
August 26, 2013
Export Citation:
Assignee:
UNIV TOKYO
International Classes:
C12N15/09; C07K7/04; C07K7/06; C07K7/08; C12P21/00; C12Q1/68; G01N33/566
Domestic Patent References:
| JP2010504313A | 2010-02-12 | |||
| JP2012058092A | 2012-03-22 | |||
| JP2012006917A | 2012-01-12 | |||
| JP2008505858A | 2008-02-28 |
Foreign References:
| WO2012074130A1 | 2012-06-07 |
Other References:
エムディー シャミン レザ: "Development and application of dynamic virtual bicyclic peptides as a prospective therapeutic scaffo", 東京大学学位論文要旨, JPN6017018041, 25 March 2013 (2013-03-25), pages 129152, ISSN: 0004050273
Attorney, Agent or Firm:
Yoshiyuki Inaba
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito
Ayako Kobayashi
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito
Ayako Kobayashi
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