MANUFACTURE OF VACCINES THAT CONTAIN BOTH HEPATITIS B VIRUS SURFACE ANTIGEN AND SURFACTANT

Japanese Patent JP2013056940

A

To provide a method which does not require addition of surfactants as different components in a manufacturing method, for a combination vaccine containing a non-ionic surfactant.

When preparing HBsAg for use in a combination vaccine, it is known to add a non-ionic surfactant after the HBsAg has been purified. Adding surfactants after purification of HBsAg is not optimal, however, as it requires a separate processing step during manufacture. Thus the invention uses surfactants during HBsAg purification.

JP2002520299	[Title of Invention] Polynucleotide Vaccine Formulation
WO/2005/080575	NUCLEIC ACID CONSTRUCT CONTAINING FULL-LENGTH GENOME OF HUMAN HEPATITIS C VIRUS, RECOMBINANT FULL-LENGTH VIRUS GENOME REPLICATIVE CELL HAVING THE NUCLEIC ACID CONSTRUCT TRANSFERRED THEREINTO AND METHOD OF CONSTRUCTING HEPATITIS C VIRAL PARTICLES
JP2004537271	In vitro system for RNA-dependent RNA polymerase (RDRP) virus replication

CONTORNI MARIO

JP2012279058A

March 28, 2013

December 21, 2012

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NOVARTIS VACCINES & DIAGNOSTIC

A61K39/29; A61K39/05; A61K39/08; A61K39/09; A61K39/095; A61K39/102; A61K39/295; A61P31/04; A61P31/20; C07K14/02; A61K39/00

JP2004505992A	2004-02-26
JP2004517866A	2004-06-17
JPS6136228A	1986-02-20

JPN6012006987; ＬＡＮＧＵＥ，Ｊ．　ｅｔ　ａｌ: 'Ｐｅｒｓｉｓｔｅｎｃｅ　ｏｆ　ａｎｔｉｂｏｄｉｅｓ　ａｔ　５-６　ｙｅａｒｓ　ｏｆ　ａｇｅ　ｆｏｒ　ｃｈｉｌｄｒｅｎ　ｗｈｏ　ｈａｄ　ｒｅｃｅｉｖｅｄ　ａ　ｐｒｉｍａｒｙ　ｓｅｒｉｅｓ　ｖａｃｃｉｎａ' Ｖａｃｃｉｎｅ Ｖｏｌ．２２，　Ｎｏ．１１-１２, 2004, ｐ．１４０６-１４
JPN6012006988; ＡＲＩＳＴＥＧＵＩ，Ｊ．　ｅｔ　ａｌ: 'Ｃｏｍｐａｒｉｓｏｎ　ｏｆ　ｔｈｅ　ｒｅａｃｔｏｇｅｎｉｃｉｔｙ　ａｎｄ　ｉｍｍｕｎｏｇｅｎｉｃｉｔｙ　ｏｆ　ａ　ｃｏｍｂｉｎｅｄ　ｄｉｐｈｔｈｅｒｉａ，　ｔｅｔａｎｕｓ，　ａｃｅｌｌｕｌａｒ　ｐｅｒ' Ｖａｃｃｉｎｅ Ｖｏｌ．２１，　Ｎｏ．２５-２６, 2003, ｐ．３５９３-６００

Hidesaku Yamamoto
Natsuki Morishita

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