Title:
METHOD FOR INHIBITING HISTAMINE RELEASE
Document Type and Number:
Japanese Patent JPH01203323
Kind Code:
A
Abstract:
PURPOSE: To inhibit or suppress the release of histamine from the mast cells of a mammalian by bringing the mast cells into contact with a benzo-C- phenanthridine alkaloid. CONSTITUTION: The mast cells of a mammalian are brought into contact with a benzo-C-phenanthridine alkaloid, sanguinarine. The benzo-C-phenanthridine alkaloids can be extracted from the plants of the families Papaveracease, Fumariaceae and Berboridaceae, and includes sanguinarine, chelerubine, macarpine and allocryptopine. The sanguinarine (1-10μM) inhibits the release of histamine stimulated with a known compound 48/80 as a histamine-releasing agent. The inhibition action is exhibited, also when the release of the histamine is induced with a histamine-inducing agent comprising concanavalin A, a polypeptide (fraction A) or calcium ionophore A23187.
Inventors:
SEIZABUROU SAKAMOTO
KATSUMI SUGIYAMA
KATSUMI SUGIYAMA
Application Number:
JP2737588A
Publication Date:
August 16, 1989
Filing Date:
February 08, 1988
Export Citation:
Assignee:
BIPONTO PHARMACEUT INC
International Classes:
A61K36/18; A61K31/395; A61K31/435; A61K31/47; A61K31/473; A61K36/00; A61K36/29; A61P43/00; C07D221/18; C07D455/03; C07D491/056; C07D491/153; (IPC1-7): A61K31/395; A61K31/435; A61K31/47; A61K35/78; C07D221/18; C07D455/03; C07D491/056; C07D491/153
Attorney, Agent or Firm:
Akira Asamura (2 outside)
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