Title:
METHOD FOR PRODUCING 4,4,7-TRIFLUORO-1,2,3,4-TETRAHYDRO-5H-1-BENZAZEPINE COMPOUND AND INTERMEDIATE FOR SYNTHESIS THEREOF
Document Type and Number:
Japanese Patent JP2019014716
Kind Code:
A
Abstract:
To provide a method for producing a 4,4,7-trifluoro-1,2,3,4-tetrahydro-5H-1-benzazepine compound which has a superior agonistic activity to an arginine vasopressin V2 receptor and is useful as an active ingredient for a pharmaceutical composition for preventing and/or treating urinary frequency, urinary incontinence, enuresis, central diabetes insipidus, nocturia, nocturnal enuresis, or the like; and useful intermediates for use in the production methods.SOLUTION: A production method comprises: a step of reacting a compound of the formula (5) with thionyl chloride (4) to produce a compound of the formula (3); and a step of amidating the compound of the formula (3) by reacting with 2-aminoethanol (2).SELECTED DRAWING: None
Inventors:
KAWAZOE SOICHIRO
AKIBA MASAHIRO
SATO KIICHI
MIYAFUJI AKIO
KOHITSU KAZUYOSHI
ITO JUNJI
HIRASAWA SHUN
KOSHIO HIROYUKI
AKIBA MASAHIRO
SATO KIICHI
MIYAFUJI AKIO
KOHITSU KAZUYOSHI
ITO JUNJI
HIRASAWA SHUN
KOSHIO HIROYUKI
Application Number:
JP2018152818A
Publication Date:
January 31, 2019
Filing Date:
August 15, 2018
Export Citation:
Assignee:
TACURION PHARMA INC
International Classes:
C07D223/16; A61K31/55; A61P13/02; C07C51/09; C07C51/367; C07C65/21; C07C67/03; C07C69/92; C07C303/40; C07C311/19
Attorney, Agent or Firm:
Hiraki International Patent Office