METHOD FOR PRODUCING OPTICALLY ACTIVE 6-SULFONYLOXYMETHYL-1,3-DIOXAN-4-YL-ACETIC ACID DERIVATIVE

Title:

METHOD FOR PRODUCING OPTICALLY ACTIVE 6-SULFONYLOXYMETHYL-1,3-DIOXAN-4-YL-ACETIC ACID DERIVATIVE

Document Type and Number:

Japanese Patent JP2004035514

Kind Code:

A

Abstract:

To provide a method capable of readily producing an optically active 6-sulfonyloxymethyl-1,3-dioxan-4-yl-acetic acid derivative useful as a medicinal intermediate in a short process from inexpensive and readily available raw materials.

A readily available optically active 5,6-dihydroxy-3-oxohexanoic acid derivative is sulfonated in the presence of a base to produce an optically active 5-hydroxy-3-oxo-6-sulfonyloxyhexanoic acid derivative, which is then reduced to produce an optically active 3,5-dihydroxy-6-sulfonyloxyhexanoic acid derivative, which is further acetalized to produce the optically active 6-sulfonyloxymethyl-1,3-dioxan-4-yl-acetic acid derivative.

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Inventors:

KISHIMOTO SHIGEMI
NISHIYAMA AKIRA
NAGASHIMA NOBUO
INOUE KENJI

Application Number:

JP2002198020A

Publication Date:

February 05, 2004

Filing Date:

July 05, 2002

Export Citation:

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Assignee:

KANEGAFUCHI CHEMICAL IND

International Classes:

C07B53/00; C07B61/00; C07C303/24; C07C303/28; C07C303/30; C07C309/73; C07D319/06; C07C305/06; (IPC1-7): C07C303/30; C07C303/28; C07C309/73; C07D319/06

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