MODIFIED PEPTIDE AS THERAPEUTIC AGENT

Japanese Patent JP2007091747

A

To provide fusion of an Fc domain and a biologically active peptide and a method for manufacturing a pharmaceutical agent using the biologically active peptide.

A pharmacologically active compound is manufactured by a process comprising (a) selecting at least one peptide that modulates the activity of a protein of interest and (b) preparing a pharmacological substance comprising the Fc domain covalently linked to at least one amino acid of the selected peptide. Linkage to a vehicle increases the half-life of the peptide, which otherwise would be quickly decomposed in vivo. The preferred vehicle is the Fc domain. Preferably, the peptide is selected by phage display, Eschericia coli display, RNA-peptide screening or chemical substance-peptide screening.

FEIGE ULRICH
LIU CHUAN-FA
CHEETHAM JANET
BOONE THOMAS CHARLES

JP2006288347A

April 12, 2007

October 24, 2006

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AMGEN

C07K19/00; A61K38/00; G01N33/50; A61K47/48; A61P3/04; A61P7/00; A61P7/06; A61P9/00; A61P19/00; A61P19/02; A61P29/00; A61P31/04; A61P31/12; A61P31/18; A61P35/00; A61P35/02; A61P37/02; A61P43/00; C07K14/47; C07K14/48; C07K14/505; C07K14/52; C07K14/525; C07K14/545; C07K16/18; C12N1/21; C12N9/64; C12N15/09; C12N15/62; C12N15/70; C12P21/02; G01N33/15; G01N33/566; C12R1/19; C07K; C12N

US5739277A	1998-04-14
WO2004026329A1	2004-04-01
WO1998024477A1	1998-06-11
US5349053A	1994-09-20
WO1998025146A1	1998-06-11

Yoshio Kawaguchi
Makoto Ono
Katsuma Osaki

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