Title:
乳癌分子サブタイプのナノメカニカルプロファイリング
Document Type and Number:
Japanese Patent JP6860934
Kind Code:
B2
Abstract:
The invention relates to a method for classifying a tissue sample obtained from mammary carcinoma. The method comprises determining a stiffness value for each of a plurality of points on said tissue sample, resulting in a stiffness distribution, and assigning said sample to a breast cancer subtype and nodal status based on said stiffness distribution.
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Inventors:
Mary, Prodinek
Ellen Obermann
Elter, Philip
Laez, Christian
Ellen Obermann
Elter, Philip
Laez, Christian
Application Number:
JP2018520612A
Publication Date:
April 21, 2021
Filing Date:
October 24, 2016
Export Citation:
Assignee:
Universitet Basel
International Classes:
G01N33/483; G01N33/48; G01N33/68; G01Q60/36
Domestic Patent References:
| JP2013545110A |
Foreign References:
| US20130266665 |
Other References:
I. ACERBI et al.,Human Breast Cancer Invasion and Aggression Correlates with ECM Stiffening and Immune Cell Infiltration,INTEGRATIVE BIOLOGY,Vol.7, No.10,pp.1120-1134
Christian Raez et al.,Taking the atomic force microscopy to the clinic: Predicting the prognosis and recurrence of breast cancer by integrating the nanomechanical profiles of primary tumor and its adjacent tissue,5th Annual Synmposium Physics of Cancer,2014年,URL,https://conference.uni-leipzig.de/poc/2014/abstract.php?id=70
Marija Plodinec et al.,The Nanomechanical Signature of Breast Cancer,Nature Nanotechnology,2012年,Vol.7, No.11,pp.757-765
HARDIK J. PANDYA et al.,Accurate Characterization of Benign and Cancerous BreastTissues: Aspecific Patient Studies using Piezoresistive Microcantilevers,BIOSENSORS AND BIOELECTRONICS,2015年,Vol.63,pp.414-424
Christian Raez et al.,Taking the atomic force microscopy to the clinic: Predicting the prognosis and recurrence of breast cancer by integrating the nanomechanical profiles of primary tumor and its adjacent tissue,5th Annual Synmposium Physics of Cancer,2014年,URL,https://conference.uni-leipzig.de/poc/2014/abstract.php?id=70
Marija Plodinec et al.,The Nanomechanical Signature of Breast Cancer,Nature Nanotechnology,2012年,Vol.7, No.11,pp.757-765
HARDIK J. PANDYA et al.,Accurate Characterization of Benign and Cancerous BreastTissues: Aspecific Patient Studies using Piezoresistive Microcantilevers,BIOSENSORS AND BIOELECTRONICS,2015年,Vol.63,pp.414-424
Attorney, Agent or Firm:
Toshiaki Morimoto