NEW A1 ADENOSINE RECEPTOR AGONIST - University of Florida Research Foundation, Inc.

Title:

NEW A1 ADENOSINE RECEPTOR AGONIST

Document Type and Number:

Japanese Patent JP3892254

Kind Code:

B2

Abstract:

PROBLEM TO BE SOLVED: To obtain a new compound capable of binding to an adenosine receptor, especially an adenosine analogue comprising an epoxide moiety.
SOLUTION: This composition which is a composition containing an N6 adenosine compound and a pharmaceutically acceptable carrier and capable of providing an A1 adenosine receptor and has a structure in which the N6 adenosine compound is represented by the following general formula (I) [in the formula (I), R is (II) or (III); and, in the formula (III), R1 is a 1-4C alkyl]. The adenosine agonist has therapeutic usefulness within a wide range of application such as regulation of the heart and kidney. The administration of the compound is useful as an antiarrhythmic agent. Thereby, the pharmaceutical composition comprising the compound as an active ingredient is useful for prophylactic or therapeutic treatment of cardiac arrthythmia of humans or other mammals.

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Inventors:

Bella Dinelli Louise
Olsson Ray
Baker stefan
Scammels Peter Jay.
Milner Peter Gerald
Pfister Jag Roland
Screener George Frederick

Application Number:

JP2001225995A

Publication Date:

March 14, 2007

Filing Date:

October 28, 1994

Export Citation:

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Assignee:

University of Florida Research Foundation, Inc.

International Classes:

C07H19/167; A61K31/52; A61K31/522; A61K31/7076; A61P1/16; A61P3/10; A61P9/00; A61P9/06; A61P11/00; A61P11/06; A61P11/08; A61P13/02; A61P13/12; A61P43/00; C07D473/06; C07D473/08; C07D519/00; C07H19/16; A61P9/10; (IPC1-7): C07H19/167; A61K31/7076; A61P1/16; A61P3/10; A61P9/00; A61P9/06; A61P11/00; A61P11/06; A61P13/12

Domestic Patent References:

JP5577395A

Other References:

J.Med.Chem.,1985年,Vol.28, No.10,p.1383-1384

Attorney, Agent or Firm:

Hatsushi Shimizu
Koichi Niimi

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