Title:
正常眼圧緑内障モデル及びそれを用いた被験物質の評価方法
Document Type and Number:
Japanese Patent JP4543154
Kind Code:
B2
Abstract:
It is intended to provide a simple normal-tension glaucoma model capable of spontaneously, age-dependently and surly developing conditions similar to symptoms of normal-tension glaucoma which occurs more frequently in elder people, and a method of evaluating therapeutic effect on normal-tension glaucoma whereby a drug useful in treating and diagnosing can be conveniently screened by using the normal-tension glaucoma model. A normal-tension glaucoma model comprising a nonhuman mammal, which is deficient in a transcriptional regulator NF-ºBp50 and thus spontaneously develops the normal-tension glaucoma symptom age-relatedly, an organ or a tissue thereof or cells collected from any of the same. A method of evaluating therapeutic effect on normal-tension glaucoma of a test substance which comprises administering or adding the test substance to the above-described nonhuman mammal, an organ or a tissue thereof or cells collected from any of the same, and measuring a morphological defect, cell count, pressure, the expression amount or activity strength of a protein, the expression amount of a nucleic acid and/or the activity strength of an antibody in the organ, tissue and/or cells as indication(s) for the evaluation.
More Like This:
Inventors:
Takuma Hayashi
Yasuko Takahashi
Tomoko Yanagihira
Shunichiro Taniguchi
Murata Toshinori
Yasuko Takahashi
Tomoko Yanagihira
Shunichiro Taniguchi
Murata Toshinori
Application Number:
JP2009522688A
Publication Date:
September 15, 2010
Filing Date:
July 11, 2008
Export Citation:
Assignee:
Shinshu University
International Classes:
A01K67/027; C12N5/10; C12N15/09; C12Q1/02; G01N33/48
Domestic Patent References:
| JP2004313188A | 2004-11-11 |
Foreign References:
| WO2004092371A1 | 2004-10-28 |
Attorney, Agent or Firm:
Yoshio Komiya
Hiroyuki Onishi
Hiroyuki Onishi