NOVEL 1-ALKYL SUBSTITUTED BENZIMIDAZOLE DERIVATIVE

Title:

NOVEL 1-ALKYL SUBSTITUTED BENZIMIDAZOLE DERIVATIVE

Document Type and Number:

Japanese Patent JPS63301879

Kind Code:

A

Abstract:

Novel 1-alkyl substituted benzimidazole derivatives of formula wherein -A<1>=A<2>-A<3>=A<4>- is a bivalent radical having the formula -CH=CH-CH=CH- (a-1), -N=CH-CH=CH- (a-2), -CH=N-CH=CH- (a-3), -CH=CH-N=CH- (a-4), -CH=CH-CH=N- (a-5), -N=CH-N=CH- (a-6), or -CH=N-CH=N- (a-7); B is NR<3>, CH2, O, S, SO or SO2; L is hydrogen, C1-6alkylcarbonyl, C1-6alkylsulfonyl, C1-6alkyloxycarbonyl, Ar<2>-C1-6alkyloxycarbonyl, Ar<2>-carbonyl, Ar<2>-sulfonyl, C3-6cycloalkyl, C2-6alkenyl optionally substituted with Ar<2>, C1-12alkyl, a radical of formula -Alk-R<4> (b-1), -Alk-Y-R<5> (b-2), -Alk-Z<1>-C(X)-Z<2>-R<6> (b-3), or -CH2-CHOH-CH2-O-R<7> (b-4); the pharmaceutically acceptable acid addition salts and stereochemically isomeric forms thereof, which compounds are anti-allergic agents; pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions.

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Inventors:

FURANSU EDOUARUTO JIYANSENSU
GASUTON SUTANISURASU MARUSERA
JIYOSEFU REO GISURANUSU TOREMA
FURANSOWA MARIA SOMEN

Application Number:

JP5276288A

Publication Date:

December 08, 1988

Filing Date:

March 08, 1988

Export Citation:

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Assignee:

JANSSEN PHARMACEUTICA NV

International Classes:

A61K31/435; A61K31/45; A61K31/47; A61K31/495; A61K31/52; A61K31/522; A61P37/08; A61P43/00; C07D207/14; C07D213/75; C07D401/06; C07D401/12; C07D401/14; C07D403/06; C07D403/12; C07D405/14; C07D223/12; C07D471/04; C07D473/00; C07D473/04; C07D473/28; C07D473/30; C07D473/40; C07D487/04; C07D513/04; C07D519/00; (IPC1-7): A61K31/435; A61K31/495; A61K31/52; C07D207/14; C07D213/75; C07D223/12; C07D401/12; C07D401/14; C07D405/14; C07D471/04; C07D473/04; C07D473/28; C07D473/30; C07D473/40; C07D487/04; C07D519/00

Other References:

J HETEROCYCLIC CHEM 24 -1=1987

Attorney, Agent or Firm:

Heikichi Odashima

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