Title:
THERAPEUTIC POLYNUCLEOTIDES AGAINST ONCOGENIC VIRAL POLYPEPTIDE-POSITIVE TUMORS
Document Type and Number:
Japanese Patent JP2018038405
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide polynucleotides encoding antigenic polypeptides that elicit immune response to oncogenic viral polypeptide.SOLUTION: The invention provides an isolated polynucleotide comprising a first polynucleotide sequence encoding a first antigenic polypeptide, where the first antigenic polypeptide is featured by: a. it comprises an amino acid sequence having at least 70% sequence identity to the amino acid sequence of a first oncogenic viral polypeptide, b. it can elicit an immune response to the first oncogenic viral polypeptide in an immune-competent host; c. it is non-oncogenic in the immune-competent host. A composition comprising the polynucleotide and a use method thereof are also provided. In some embodiment, the virus may be human papilloma virus.SELECTED DRAWING: None
Inventors:
JOHN H LEE
DANIEL W VERMEER
DANIEL W VERMEER
Application Number:
JP2017188121A
Publication Date:
March 15, 2018
Filing Date:
September 28, 2017
Export Citation:
Assignee:
SANFORD HEALTH
International Classes:
C12N15/09; A61K31/7088; A61K39/12; A61K47/42; A61P31/20; A61P35/00; C07K14/01
Foreign References:
| WO2010129339A2 | 2010-11-11 |
Other References:
VACCINE, vol. Vol.22, JPN6016049499, 2004, pages 520 - 527
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Tomohiro Maruyama
Yasuhito Suzuki
Norio Omori
Tomohiro Maruyama
Yasuhito Suzuki