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Patent Searching and Data


Title:
PREPARATION OF 5-CARBOXYVINYLURACIL NUCLEOSIDE
Document Type and Number:
Japanese Patent JPS59163394
Kind Code:
A
Abstract:

PURPOSE: To obtain the titled compound useful as an intermediate for synthesizing antiviral activator simply at low cost in high yield, by reacting a 5-formyluracil nucleoside with a specific phosphorane, hydrolyzing the reaction product.

CONSTITUTION: A 5-formyluracil nucleoside shown by the formula I (R1 is H, or OH) is reacted with a phosphorane shown by the formula (R2)3P=CXCOOR3 (R2 and R3 are alkyl, or aryl; X is H or halogen), to give a 5-alkoxy or aloxycarbonylvinyluracil nucleotide shown by the formula II. This compound is then hydrolyzed preferably with an alkali at 0°CW room temperature for serveral hours, to give the desired compound shown by the formula III. The compound shown by the formula III wherein group X is halogen is a novel compound.


Inventors:
IKEDA KAZUYOSHI
Application Number:
JP3795483A
Publication Date:
September 14, 1984
Filing Date:
March 08, 1983
Export Citation:
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Assignee:
YAMASA SHOYU KK
International Classes:
C07H19/06; C07H19/073; C07H19/09; (IPC1-7): C07H19/06