PROCESS FOR PREPARATION OF PHARMACOLOGICALLY ACTIVE -ASARONE DERIVED FROM TOXIC -ASARONE-RICH CALAMUS OIL

Title:

PROCESS FOR PREPARATION OF PHARMACOLOGICALLY ACTIVE -ASARONE DERIVED FROM TOXIC -ASARONE-RICH CALAMUS OIL

Document Type and Number:

Japanese Patent JP2008208134

Kind Code:

A

Abstract:

To develop a simple process for preparation of -asrone exclusively with no inclusion of any other asarone isomers (namely -isomer and/or -isomer).

This invention relates to a process for preparing high-purity -asarone or trans-2,4,5-trimetoxycinnamaldehyde, and 2,4,5-trimethoxyphenylpropiophenone with a high yield from -asarone-rich Acorus calmus oil including -asarone or -asarone and -asarone. The process comprise hydrogenation and following treatment with DDQ in a dried organic solvent, or -asarone is further treated with -asarone or -asarone rich Acorus calamus oil in aqueous organic solvent to prepare the intermediate products, 2,4,5-trimethoxypropiophenone, then the product is reduced with sodium borohydride to prepare corresponding 2,4,5-trimethoxypropanol, and is finally treated with an dehydrogenation agent.

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Inventors:

SINHA ARUN KUMAR
ACHARYA RUCHI
JOSHI BHUPENDRA PRASAD

Application Number:

JP2008101982A

Publication Date:

September 11, 2008

Filing Date:

April 09, 2008

Export Citation:

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Assignee:

COUNCIL SCIENT IND RES

International Classes:

C07C41/18; C07B61/00; C07C43/215

Attorney, Agent or Firm:

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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