Title:
イオシメノールを調製するためのプロセス
Document Type and Number:
Japanese Patent JP2011509943
Kind Code:
A
Abstract:
A process for the preparation of iosimenol comprising reacting 5,5′-[(1,3-dioxo-1,3-propanediyl)diimino]bis[N-(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide] (C-VI) with a 3-halo-1,2-propanediol in an aqueous solvent. A process for the preparation of C-VI comprising reacting 3,3′-[(1,3-dioxo-1,3-propanediyl)diimino]bis[5-(aminocarbonyl)-2,4,6-triiodobenzoyl chloride] (C-V) with 3-amino-1,2-propanediol in the presence of an inorganic base and a suitable non-aqueous polar solvent. A process for the preparation of C-V comprising reacting 3-amino-5-(aminocarbonyl)-2,4,6-triiodobenzoyl chloride (C-IV) with malonyl dichloride in a solvent comprising a suitable ester solvent, a suitable nitrile solvent or mixtures thereof.
Inventors:
Bailey, Alan Earl.
Jones, Michael M.
Neller, Mills Tea.
Petrov, Alexander N.
White, David H.
Egan, Oliver
Rooney, Fiona
Jones, Michael M.
Neller, Mills Tea.
Petrov, Alexander N.
White, David H.
Egan, Oliver
Rooney, Fiona
Application Number:
JP2010542427A
Publication Date:
March 31, 2011
Filing Date:
January 14, 2009
Export Citation:
Assignee:
Mallinckrodt INC.
International Classes:
C07C231/08; C07C231/02; C07C237/30; C07C237/32; C07B61/00
Domestic Patent References:
JPH03115232A | 1991-05-16 | |||
JPS57145849A | 1982-09-09 | |||
JPS537637A | 1978-01-24 | |||
JP2007528424A | 2007-10-11 |
Attorney, Agent or Firm:
Takeshi Oshio