To provide a process for producing 1-substituted-trans-3-(substituted amino)piperidin-4-ol without using sodium azide which requires careful handling.

The production process for 1-substituted-trans-3-(substituted amino)piperidin-4-ol represented by formula (IV-1) includes a step of allowing 1-substituted-3,4-epoxy piperidine to react with an amine compound represented by formula (II) (wherein A1 and A2 each represent a 1-12C alkyl group which may have one or more aromatic hydrocarbon ring groups) in the presence of a solvent.