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Title:
PRODUCTION OF 1-ALKYL-(AMINOMETHYL)PIPERIDINES
Document Type and Number:
Japanese Patent JPH10273482
Kind Code:
A
Abstract:

To produce the subject compound by a one step process in high yield by catalytically reducing l-alkyl-cyanopyridinium salts in the presence of an acid.

1-Alkyl-cyanopyridinium salts of formula I [R1 and R2 are each an alkyl; A- is an anion; (n) is 0-4] is catalytically reduced in the presence of an acid such as hydrochloric acid to provide the objective 1- alkyl-(aminomethyl)piperidines of formula II in the method for producing the 1-alkyl-(aminomethyl)piperidines. The catalytic reduction is carried out by using a noble metal catalyst (e.g. rhodium) in a solvent (e.g. water) at 50-70°C under 0.3-5 MPa hydrogen pressure. The compound of formula II is useful as a raw material for a drug. A pyridine ring and a cyano group of the compound of formula I are reduced by a reaction operation of one step and thereby the compound of formula II is readily obtained.


Inventors:
UNO OSAMU
Application Number:
JP9499497A
Publication Date:
October 13, 1998
Filing Date:
March 28, 1997
Export Citation:
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Assignee:
KOEI CHEMICAL CO
International Classes:
C07D211/02; B01J23/44; B01J23/46; C07B61/00; C07D211/26; (IPC1-7): C07D211/26; B01J23/44; B01J23/46; C07D211/02