Title:
線維芽細胞増殖因子受容体自己リン酸化を阻害するキノリン誘導体およびキナゾリン誘導体並びにそれらを含有する医薬組成物
Document Type and Number:
Japanese Patent JP4383870
Kind Code:
B2
Abstract:
An objective of the present invention is to provide novel compounds which have inhibitory activity against autophosphorylation of an FGF receptor family and, when orally or intraveneously administered, can suppress the growth of cancer cells. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X represents CH or N; Z represents 0 or S; Q represents NR<10>, CR<11>R<12>, carbonyl, O, S(=O)m, wherein m is 0 to 2, or urea; R<1> to R<3> each independently represent H, OH, halogen, nitro, amino, alkyl, alkoxy or the like in which the alkyl and alkoxy groups are optionally substituted; R<4> represents H; R<5> to R<8> each independently represent H, halogen, alkyl, or alkoxy; and R<9> represents an optionally substituted carbocyclic or heterocyclic group.
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Inventors:
Atsushi Miwa
Tetsuya Yoshino
Ritsushi Osawa
Teruyuki Sakai
Shimizu Jutsu
Yasunari Fujiwara
Tetsuya Yoshino
Ritsushi Osawa
Teruyuki Sakai
Shimizu Jutsu
Yasunari Fujiwara
Application Number:
JP2003536212A
Publication Date:
December 16, 2009
Filing Date:
October 17, 2002
Export Citation:
Assignee:
Kyowa Hakko Kirin Co., Ltd.
International Classes:
C07D215/22; A61K31/47; A61K31/4709; A61K31/496; A61K31/5377; A61K31/55; A61K31/551; A61P1/00; A61P1/18; A61P11/00; A61P13/12; A61P15/00; A61P35/00; A61P43/00; C07D215/233; C07D239/88; C07D401/12; C07D405/12; C07D409/12; C07D413/12; C07D417/12; C07D453/02
Domestic Patent References:
| JP11158149A | ||||
| JP10505600A | ||||
| JP2003012668A |
Foreign References:
| WO1997017329A1 | ||||
| WO2001021594A1 | ||||
| WO2000043366A1 | ||||
| WO2001021596A1 | ||||
| WO2002032872A1 |
Other References:
Bioorganic & Medicinal Chemistry Letters,1997年,Vol.7, No.23,p.2935-2940
Attorney, Agent or Firm:
Kenji Yoshitake
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Yukitaka Nakamura
Konno Akio
Noritaka Yokota