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Title:
RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-BINDING PROTEIN) β1(CTNNB1) GENE EXPRESSION USING SMALL INTERFERING NUCLEIC ACID (SINA)
Document Type and Number:
Japanese Patent JP2017060472
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a compound, composition, and method for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of cadherin-binding protein β1(CTNNB1) gene expression and/or activity, and/or modulate a β-catenin gene expression pathway.SOLUTION: The present invention provides a double-stranded nucleic acid molecule that is capable of mediating or that mediates RNA interference (RNAi) against CTNNB1 gene expression, examples of such a molecule including, for example, a double stranded short interfering nucleic acid (siNA) having a specific nucleotide sequence. The siNA is a double-stranded short interfering nucleic acid (siNA) molecule comprising a sense strand and an antisense strand.SELECTED DRAWING: Figure 1

Inventors:
DUNCAN BROWN
JAMES J CUNNINGHAM
MARIAN GINDY
VICTORIA PICKERING
MATTHEW G STANTON
STEVEN M STIRDIVANT
WALTER R STRAPPS
Application Number:
JP2016191103A
Publication Date:
March 30, 2017
Filing Date:
September 29, 2016
Export Citation:
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Assignee:
SIRNA THERAPEUTICS INC
International Classes:
C12N15/09; A61K31/713; A61K47/14; A61K47/18; A61K47/24; A61K47/26; A61K47/28; A61K48/00; A61P35/00; A61P43/00; C12N15/113
Foreign References:
WO2010033581A12010-03-25
WO2010075282A12010-07-01
WO2010075286A12010-07-01
WO2010054406A12010-05-14
WO2009086558A12009-07-09
WO2008074487A22008-06-26
WO2008109460A22008-09-12
US20050112118A12005-05-26
Other References:
CLINICAL CANCER RESEARCH, vol. 9, JPN6015035008, 2003, pages 1291 - 1300, ISSN: 0003589617
Attorney, Agent or Firm:
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yoshikazu Iwase
Yasufumi Shiroyama



 
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