核酸を結合、修飾、および切断する物質の基質選択性および部位のためのＩＮＶＩＴＲＯでの高感度アッセイ

Title:

核酸を結合、修飾、および切断する物質の基質選択性および部位のためのＩＮＶＩＴＲＯでの高感度アッセイ

Document Type and Number:

Japanese Patent JP7460539

Kind Code:

B2

Abstract:

Provided herein are methods and compositions for performing highly sensitive in vitro assays to define substrate preferences and off-target sites of nucleic-acid binding, modifying, and cleaving agents.

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Inventors:

John, Jay Keith
Pattanayak, Vikram
Petri, Karl
Gehrke, Jason Michael
Sasaki, Kanae Esther

Application Number:

JP2020557220A

Publication Date:

April 02, 2024

Filing Date:

April 17, 2019

Export Citation:

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Assignee:

The General Hospital Corporation

International Classes:

C12Q1/6809; C12Q1/6881

Domestic Patent References:

JP2016531569A
JP2014523747A

Foreign References:

WO2017218979A1
WO2016081798A1
WO2017059313A1
WO2018052247A1

Other References:

Nature Biotechnology,2015年,Vol.33, No.2,pp.187-197,ONLINE METHODS, Supplementary Information

Attorney, Agent or Firm:

Hiroshi Kobayashi
Norio Omori
Sayaka Hirakawa
Yasuhito Suzuki

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