SOLUTION AND PREPARATION INCLUDING N-[ORTHO-(PARA- PIVALOYLOXYBENZENESULFONYLAMINO)-BENZOYL]GLYCINE MONOSODIUM SALT TETRAHYDRATE

Japanese Patent JP3956654

B2

PROBLEM TO BE SOLVED: To provide a method for increasing the solubility of compound (I) and provide a solution of the compound (I) with increased concentration and a pharmaceutical preparation that is produced by using the solution of increased concentration, further provide a method of producing a solution of the compound (I) with a largely increased concentration by using a mixture of water and organic solvent as a solvent and can provide the pharmaceutical preparation of the compound (I) of a largely increased content.
SOLUTION: This invention relates to a solution of compound (I): N-[o-(p- pivaloyloxybenzenesulfonylamino) benzoyl]glycine monosodium salt tetrahydrate, that includes at least one pH adjuster selected from the group of trisodium phosphate, hydrates thereof, sodium hydroxide and potassium hydroxide and to a pharmaceutical preparation using the same.

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JP2001195711A

August 08, 2007

June 28, 2001

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Ono Pharmaceutical Co., Ltd.

A61K9/08; A61K31/222; A61K9/19; A61K47/04; A61K47/10; A61P11/00; A61P43/00; (IPC1-7): A61K31/222; A61K9/08; A61K9/19; A61K47/04; A61K47/10; A61P11/00; A61P43/00

JP5194366A
JP9040692A
JP9235238A
JP60061519A

WO2001017517A1
WO1997030706A1

Kunihisa Landlord

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