SUBSTITUTED ARYL ACYLTHIOUREA AND RELATED COMPOUND; INHIBITOR OF VIRAL REPLICATION

Title:

SUBSTITUTED ARYL ACYLTHIOUREA AND RELATED COMPOUND; INHIBITOR OF VIRAL REPLICATION

Document Type and Number:

Japanese Patent JP2006225394

Kind Code:

A

Abstract:

To provide aryl thiourea derivatives and related compounds which are useful as antiviral agents.

Compounds of formula I and pharmaceutically acceptable salts there of: wherein 1-(4-(pentyloxy) phenyl)-3-(4-phenylbutanoyl) thiourea is specifically exemplified, possess potent antiviral activity. The above compounds are particularly potent and/or selective inhibitors for Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more compounds of formula I, or a salt, solvate, or acylated prodrug of such a compound, and one or more pharmaceutically acceptable carriers, excipients, or diluents.

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Inventors:

PHADKE AVINASH
CHEN DAWEI
DESHPANDE MILIND
THURKAUF ANDREW
WANG XIANGZHU
SHEN YIPING
LIU CUIXIAN
QUINN JESSE
OHKANDA JUNKO
LI SHOUMING

Application Number:

JP2006051358A

Publication Date:

August 31, 2006

Filing Date:

February 27, 2006

Export Citation:

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Assignee:

ACHILLION PHARMACEUTICALS INC

International Classes:

C07C335/26; C07D249/06; A61K9/06; A61K9/08; A61K9/10; A61K9/12; A61K9/20; A61K9/48; A61K9/70; A61K31/17; A61K31/245; A61K31/277; A61K31/341; A61K31/343; A61K31/351; A61K31/352; A61K31/366; A61K31/381; A61K31/415; A61K31/4155; A61K31/4162; A61K31/4164; A61K31/4192; A61K31/42; A61K31/421; A61K31/423; A61K31/4245; A61K31/426; A61K31/427; A61K31/428; A61K31/429; A61K31/433; A61K31/4355; A61K31/437; A61K31/4375; A61K31/4406; A61K31/4412; A61K31/443; A61K31/4439; A61K31/444; A61K31/445; A61K31/451; A61K31/4545; A61K31/455; A61K31/47; A61K31/4709; A61K31/4725; A61K31/496; A61K31/498; A61K31/50; A61K31/505; A61K31/506; A61K31/519; A61K31/53; A61K31/5375; A61K31/5377; A61K31/655; A61P1/16; A61P31/12; A61P31/14; C07C335/18; C07C335/20; C07D211/20; C07D211/22; C07D211/34; C07D211/46; C07D211/60; C07D211/64; C07D211/78; C07D213/56; C07D213/75; C07D213/82; C07D213/84; C07D213/85; C07D215/54; C07D231/14; C07D233/54; C07D233/56; C07D233/60; C07D233/90; C07D237/24; C07D239/28; C07D241/24; C07D241/42; C07D241/44; C07D253/06; C07D253/07; C07D261/18; C07D263/34; C07D263/58; C07D265/30; C07D271/08; C07D271/12; C07D277/20; C07D277/56; C07D277/68; C07D285/06; C07D295/10; C07D295/14; C07D295/15; C07D307/68; C07D307/84; C07D307/85; C07D309/38; C07D311/04; C07D311/58; C07D333/38; C07D401/04; C07D401/12; C07D405/04; C07D405/12; C07D405/14; C07D409/04; C07D409/12; C07D413/12; C07D417/04; C07D417/12; C07D417/14; C07D419/12; C07D471/04; C07D487/04; C07D491/04; C07D491/048; C07D495/04; C07D513/04

Domestic Patent References:

JPH04109271A	1992-04-10
JPH04206382A	1992-07-28
JP2007517887A	2007-07-05
JP2002540156A	2002-11-26
JP2002540150A	2002-11-26

Foreign References:

WO2005063293A1	2005-07-14
US3966968A	1976-06-29
WO2004037166A2	2004-05-06

Attorney, Agent or Firm:

Takeshi Oshio

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