PURPOSE: To provide new substituted heterocyclic carbo-xamidoesters which are used as pharmaceuticals for fibrous diseases and proline hydroxylase inhibitors and collagen biosynthesis inhibitors.
CONSTITUTION: The objective substituted heterocyclic carboxamidoesters are represented by the formula [wherein Q is O, S or NRy; X is O or S; Y is C-R3 or N; m is 0 or 1; A is a substitutable 1-4C alkylene; B is CO2V (wherein V is an alcohol VOH group and a 1-10C acyloxy-1-6C alkyl, branched, unbranched or cyclic aliphatic 1-20C alkyl, 6-16C aryl, 7-16C aralkyl or the like); R1 and R3 are each H, a 1-8C alkyl, 1-8C alkoxy, halogen, CN, OH, NH2 or the like; R2 is a carboxylic acid stereoisomeric group; and R4 is a 7-20C alkyl, 6-16C aryl, 7-16C aralkyl or the like] and include, e.g. 3-benzyloxy-5-[((4-((((+)- dehydroabietylamino)-L-valinyl)carbonyl)phenylsulfonyl)amino)carbonyl]pyridine-2- carboxylic acid (glycylethyl ester) amide.
KAARUUHAINTSU BAARINGUHAUSU
GEORUKU CHIYANKU
MARUTEIN BITSUKERU
Next Patent: METHOD FOR PRODUCING QUINALDINE