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Title:
SUBSTITUTED PYRIMIDINE AS INHIBITOR OF PROTEIN KINASE AND METHOD FOR PREPARING PYRIMIDINE DERIVATIVE
Document Type and Number:
Japanese Patent JP2014111662
Kind Code:
A
Abstract:

To provide a synthesis method that can be easily used to prepare tri- and tetra-substituted pyrimidine derivatives in a large amount, moreover to provide a method that uses a starting material that uses the minimum process and can be easily acquired, and a simple reaction medium.

The present invention provides a facile process for the preparation of tri- and tetra-substituted pyrimidines. The process is useful for preparing inhibitors of protein kinases, especially Aurora kinase. These inhibitors are useful for treating or lessening the severity of Aurora-mediated diseases or conditions. The present invention provides a method that treats a cancer of a patient, and the method includes a process in which a compound of a formula V or a composition thereof is administrated to the patient.


Inventors:
CHARRIER JEAN-DAMIEN
MAZZEI FRANCESCA
KAY DAVID
MILLER ANDREW
Application Number:
JP2014051076A
Publication Date:
June 19, 2014
Filing Date:
March 14, 2014
Export Citation:
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Assignee:
VERTEX PHARMA
International Classes:
C07D403/12; A61K31/439; A61K31/506; A61K31/5377; A61K31/541; A61K31/551; A61P1/16; A61P3/00; A61P5/00; A61P7/00; A61P9/00; A61P11/06; A61P13/08; A61P19/00; A61P25/00; A61P25/18; A61P25/28; A61P29/00; A61P35/00; A61P35/02; A61P37/04; A61P37/06; A61P37/08; A61P43/00; C07D239/34; C07D401/14; C07D403/14; C07D453/02
Domestic Patent References:
JP4210520B22009-01-21
JP4237701B22009-03-11
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita



 
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