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Title:
【発明の名称】触媒活性抗VIII因子アロ抗体
Document Type and Number:
Japanese Patent JP2003505434
Kind Code:
A
Abstract:
The present invention relates to a method of determining the presence of catalytic anti-Factor VIII allo-antibodies capable of degrading Factor VIII in a mammal, and of characterising the cleavage sites in said Factor VIII molecule by said catalytic anti-Factor VIII allo-antibodies. It also relates to an anti-Factor VIII allo-antibody-catalysed Factor VIII degradation inhibitor ; and to a pharmaceutical composition comprising said catalytic anti-Factor VIII allo-antibodies which are capable of degrading Factor VIII and which originate from said method of determination; and further to a pharmaceutical composition comprising said anti-Factor VIII allo-antibody-catalysed Factor VIII degradation inhibitor. Finally, the present invention relates to the application in therapeutics of said anti-Factor VIII allo-antibody-catalysed Factor VIII degradation inhibitor, of a pharmaceutical composition comprising said catalytic anti-Factor VIII allo-antibodies which are capable of degrading Factor VIII and which originate from said method of determination, and of a pharmaceutical composition comprising said anti-Factor VIII allo-antibody-catalysed Factor VIII degradation inhibitor.

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Inventors:
Sriniva Kaveli
Sebastian La Croix-Desmaze
Michelle Kaza Chicken
Application Number:
JP2001512295A
Publication Date:
February 12, 2003
Filing Date:
July 18, 2000
Export Citation:
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Assignee:
An Institute Nacional de la Sant ed Larcherche Medical (Anselm)
Bayer Pharma
International Classes:
A61K31/185; A61K38/08; A61K38/43; A61K39/395; A61K45/00; A61P7/00; A61P7/04; B01J20/281; C07K7/06; C07K14/755; C07K16/18; C12Q1/26; G01N27/447; G01N30/88; G01N33/15; G01N33/483; G01N33/50; G01N33/53; G01N33/68; G01N33/86; A61K38/00; (IPC1-7): C07K16/18; A61K31/185; A61K38/43; A61K39/395; A61K45/00; A61P7/00; A61P7/04; C07K7/06; C12Q1/26; G01N27/447; G01N30/48; G01N30/88; G01N33/15; G01N33/483; G01N33/50; G01N33/53
Attorney, Agent or Firm:
Yasuo Yasutomi



 
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