Title:
【発明の名称】複素環式スルホニルニトロメタン、その製造法および医薬製剤
Document Type and Number:
Japanese Patent JPH03503900
Kind Code:
A
Abstract:
The invention concerns pharmaceutially useful heterocyclic nitromethane compounds of the formula I: I in which ring Q is a heterocycle of 4 to 7 ring atoms, the fragment completing the ring Q having 2 to 5 atoms, one of which is carbon, oxygen, sulphur or a group of the formula -NRa-, and the remainder are carbon; Ra is hydrogen, (1-6C)alkyl, (2-6C)alkanoyl, trifluoroacetyl, phenyl, benzoyl, or phenyl(1-4C)alkyl, the latter three optionally substituted; and R1R2and R3 are independently hydrogen, hydroxy, (1-6C)alkyl, (1-6C)alkoxy, phenyl, phenoxy or phenyl(1-4C)alkyl, the last three optionally substituted, or two of R1, R2 and R3 situated on adjacent ring carbon atoms and together with said carbon atoms form a benzene ring fused to ring Q, the benzene ring itself optionally substituted, provided that when the fragment completion ring Q is of 3 atoms then at least one of R1, R2 and R3 is hydrogen; and salts thereof. Other aspects of the invention include the production of the novel compounds by analogy processes and pharmaceutical compositions of the novel compounds and of N-(nitromethylsulphonyl)morpholine for use in the treatment of diabetic complications.
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Inventors:
Marion, Keith Blakeney
Application Number:
JP50269390A
Publication Date:
August 29, 1991
Filing Date:
February 01, 1990
Export Citation:
Assignee:
Imperial Chemical Industries PLC
International Classes:
A61K31/33; A61K31/40; A61K31/403; A61K31/404; A61K31/445; A61K31/495; A61K31/535; A61K31/5375; A61P3/08; A61P27/02; A61P43/00; C12N9/99; C07D207/48; C07D209/08; C07D209/44; C07D211/54; C07D211/96; C07D215/58; C07D217/08; C07D217/22; C07D265/30; C07D277/04; C07D277/16; C07D295/22; C07D295/26; (IPC1-7): A61K31/40; A61K31/445; A61K31/495; A61K31/535; C07D207/48; C07D209/08; C07D211/54; C07D215/58; C07D217/08; C07D295/22; C12N9/99
Attorney, Agent or Firm:
Toshio Yano (1 outside)