Title:
【発明の名称】固相ペプチド合成用反応装置及び方法
Document Type and Number:
Japanese Patent JP2000511934
Kind Code:
A
Abstract:
PCT No. PCT/US98/02634 Sec. 371 Date Mar. 9, 1999 Sec. 102(e) Date Mar. 9, 1999 PCT Filed Feb. 10, 1998 PCT Pub. No. WO98/34633 PCT Pub. Date Aug. 13, 1998A solid phase peptide synthesis reactor system and method of operating the reactor are provided. The reactor system includes a basket rotatable about an axis within a housing and a receiver which delivers fluid to, and collects fluid from, the housing. The basket has a perforate side wall against which a resin cake for the peptide synthesis is formed. The reactor and receiver form a loop or circuit through which solutions are circulated. The circulation of the solutions prevents the reactor from flooding so that the basket will not be submerged in solution and allows for the use of less liquid. Thus greater amino acid concentrations may be used. The method includes forming a resin cake of uniform depth on the wall of the spinning basket and spraying the solutions against the resin cake while spinning the basket. The solutions will pass through the resin cake and drain to the receiver to be circulated or recycled through the system or discharged from the system. Before a subsequent solution is introduced into the reactor system, the prior solution is purged from the system to help control exposure time of the peptide to the solutions.
More Like This:
| JPH0891841 | PRODUCTION OF FERROELECTRIC FILM |
| WO/2014/096779 | MULTI-CHANNEL CHEMICAL REACTOR |
| JP2010264446 | STRUCTURE EXCELLENT IN FLUID FLOWING PERFORMANCE |
Inventors:
Van ecker, patrick, eduard
Kinari Saiki
Ledder, Robert, F.
Kinari Saiki
Ledder, Robert, F.
Application Number:
JP53504398A
Publication Date:
September 12, 2000
Filing Date:
February 10, 1998
Export Citation:
Assignee:
Malincklot Chemical Incorporated
International Classes:
B01J19/00; C07K1/04; C07K5/06; B01J19/18; C40B40/10; C40B60/14; (IPC1-7): C07K5/06; B01J19/18; C07K1/04
Attorney, Agent or Firm:
Soga Doteru (6 people outside)