Title:
ミトコンドリアカルシウム/ナトリウムアンチポーターの阻害による真性糖尿病の処置
Document Type and Number:
Japanese Patent JP2005503993
Kind Code:
A
Abstract:
The invention provides compositions and methods for altering insulin secretion using an agent that inhibits calcium efflux via the mitochondrial calcium/sodium antiporter (MCA). Methods of treatment are thereby provided, and are particularly useful for treatment of subjects having, or suspected of being at risk for having, diabetes mellitus. Compositions and methods related to the identification of gene sequences encoding the mitochondrial calcium/sodium antiporter, expression of such sequences and screening assays using expressed MCA products are also provided.
Inventors:
Anderson, Kristen M.
Davis, Robert E.
Gosh, Somitraes.
Pay, yazon
Davis, Robert E.
Gosh, Somitraes.
Pay, yazon
Application Number:
JP2002528274A
Publication Date:
February 10, 2005
Filing Date:
September 20, 2001
Export Citation:
Assignee:
Mitco
International Classes:
G01N33/53; A61K31/553; A61K31/554; A61K45/00; A61K45/06; A61P3/10; A61P43/00; C07D267/14; C07D281/10; G01N33/543; G01N33/566; (IPC1-7): A61K45/00; A61K31/553; A61K31/554; A61P3/10; A61P43/00; C07D267/14; G01N33/53; G01N33/543; G01N33/566
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita