TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONIST

Title:

TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONIST

Document Type and Number:

Japanese Patent JP3630449

Kind Code:

B2

Abstract:

PURPOSE: To obtain a novel tricyclic compound which has antagonist activity at V1 and/or V2 receptors and exhibits in vivo vasopressin antagonist activity and is useful for treatment of diseases characterized by excess renal reabsorption of water.
CONSTITUTION: A compound of formula I {wherein Y is (CH2)n ((n) is 0-2), O, S, NH, NCOCH3, an N-alkyl, a CH-alkyl, CO or the like; A-B is formula II, formula III {(m) is 1 or 2; R3 is a CO-Ar [Ar is formula IV-formula VI (X is O, S, NCH3 or the like; R4 is H, an alkyl or the like; R5 is H, CH, Cl, Br or the like; R6 is formula VII or he like; R7 is R5 or CF3)]}; R1 is H, a halogen, OH, an S-alkyl, an alkyl or the like; R2 is H, a halogen, an alkyl or the like; formula VIII is a substitutable united phenyl, a 5-membered aromatic (unsaturated) heterocycle having one htereroatome, a 6-membered aromatic (unsaturated) heterocycle having one N}, for example, N-[(10,11-dihydro-5- dibenz[b,f]azepin-5-yl)carbonyl]phenyl-2-methylbenzamide.

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Inventors:

J Day Albright
Marvin F Lake
Fuku-wa Sam
Shimei May Doe

Application Number:

JP19588694A

Publication Date:

March 16, 2005

Filing Date:

July 28, 1994

Export Citation:

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Assignee:

Wyeth Holdings Corporation

International Classes:

A61K31/395; A61K31/435; A61K31/473; A61K31/55; A61K31/551; A61K31/553; A61K31/554; A61P1/16; A61P9/04; A61P11/00; A61P13/02; A61P15/00; A61P25/00; A61P43/00; C07D221/12; C07D221/18; C07D223/18; C07D223/20; C07D223/22; C07D223/28; C07D225/00; C07D225/08; C07D243/18; C07D243/38; C07D245/04; C07D267/16; C07D267/18; C07D267/20; C07D279/30; C07D281/00; C07D281/14; C07D281/16; C07D285/00; C07D285/38; C07D401/12; C07D405/12; C07D407/12; C07D409/12; C07D471/04; C07D487/04; C07D495/04; C07D498/04; C07D513/04; (IPC1-7): C07D221/12; A61K31/395; A61K31/473; A61K31/55; A61K31/551; A61K31/553; A61K31/554; A61P1/16; A61P9/04; A61P11/00; A61P13/02; A61P25/00; A61P43/00; C07D223/18; C07D223/20; C07D223/28; C07D225/08; C07D243/38; C07D267/20; C07D281/16; C07D285/38; C07D401/12; C07D407/12; C07D409/12; C07D487/04; C07D495/04; C07D498/04; C07D513/04

Foreign References:

WO1995003305A1

Attorney, Agent or Firm:

Heikichi Odashima

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