Title:
抗増殖剤としてのＤＤＸ３阻害剤の使用
Document Type and Number:
Japanese Patent JP7073269
Kind Code:
B2
Abstract:
The present invention refers to compounds of formula I or II endowed with DDX3 inhibitory activity, relative pharmaceutical compositions and their use as antihyperproliferative agents. (I) or (II)
More Like This:
| JPH04235928 | PREPARATION OF SUBSTITUTED OLEFIN OR ACETYLENE |
| WO/2020/080979 | PFKFB3 INHIBITORS AND THEIR USES |
Inventors:
Anna Laura Bligh
Maurizio Botta
Christina Tintoli
Giovanni Maga
Maurizio Botta
Christina Tintoli
Giovanni Maga
Application Number:
JP2018549791A
Publication Date:
May 23, 2022
Filing Date:
March 23, 2017
Export Citation:
Assignee:
Azienda ospedariella universitalia Senese
International Classes:
C07D249/06; A61K31/395; A61K31/4192; A61K31/4196; A61K31/42; A61K31/4245; A61K31/433; A61K31/4439; A61K31/4725; A61K31/496; A61K31/5377; A61K31/661; A61K31/7056; A61K45/00; A61P35/00; A61P35/02; A61P35/04; C07D249/08; C07D257/04; C07D261/08; C07D271/06; C07D285/12; C07D401/04; C07D401/12; C07D405/12; C07F9/6518; C07H15/26
Domestic Patent References:
| JP2007529477A | ||||
| JP2005538152A | ||||
| JP2015508102A | ||||
| JP2016502987A | ||||
| JP6749344B2 |
Foreign References:
| WO2014149084A2 | ||||
| WO2011039735A2 | ||||
| WO2011161201A1 | ||||
| KR1020140125117A | ||||
| WO2015064580A1 | ||||
| US20040006011 | ||||
| WO2012142698A1 |
Other References:
ROBERTA FAZI; CRISTINA TINTORI; ANNALAURA BRAI; ET AL,HOMOLOGY MODEL-BASED VIRTUAL SCREENING FOR THE IDENTIFICATION OF HUMAN HELICASE DDX3 INHIBITORS,JOURNAL OF CHEMICAL INFORMATION AND MODELING,米国,2015年11月23日,VOL:55, NR:11,PAGE(S):2443 - 2454,http://dx.doi.org/10.1021/acs.jcim.5b00419
SAMAL,S.K. et al,Ketorolac salt is a newly discovered DDX3 inhibitor to treat oral cancer,Scientific Reports,2015年,Vol.5, 9982,pp.1-10
Prachayasittikul, Veda et al.,Discovery of novel 1,2,3-triazole derivatives as anticancer agents using QSAR and in silico structural modification,SpringerPlus,2015年,4(1),,1-22.
KLEB K G,NEUE UMLAGERUNG VOM TYP DER SMILES-REAKTION,ANGEWANDTE CHEMIE,ドイツ,1968年04月07日,VOL:80, NR:7,PAGE(S):284 - 285,http://dx.doi.org/10.1002/ange.19680800712
SAMAL,S.K. et al,Ketorolac salt is a newly discovered DDX3 inhibitor to treat oral cancer,Scientific Reports,2015年,Vol.5, 9982,pp.1-10
Prachayasittikul, Veda et al.,Discovery of novel 1,2,3-triazole derivatives as anticancer agents using QSAR and in silico structural modification,SpringerPlus,2015年,4(1),,1-22.
KLEB K G,NEUE UMLAGERUNG VOM TYP DER SMILES-REAKTION,ANGEWANDTE CHEMIE,ドイツ,1968年04月07日,VOL:80, NR:7,PAGE(S):284 - 285,http://dx.doi.org/10.1002/ange.19680800712
Attorney, Agent or Firm:
Murayama Yasuhiko
Shinya Mihiro
Tatsuhiko Abe
Shinya Mihiro
Tatsuhiko Abe