Title:
TRIFLUOROMETHYLATION AGENT POWDER, PRODUCTION METHOD THEREOF, AND PRODUCTION METHOD OF TRIFLUOROMETHYL GROUP-CONTAINING COMPOUND
Document Type and Number:
Japanese Patent JP2014162732
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a trifluoromethylation agent powder stable at room temperature and useful as a reaction reagent and a production method thereof, and a production method of trifluoromethyl group-containing compound.SOLUTION: A zinc powder is reacted with a trifluoromethyl iodide in a N,N-dimethylformamide solvent, and it is filtrated and concentrated to obtain a trifluoromethylation agent powder represented by general formula (1) that is (CF)ZnI (DMPU)(1), where DMPU represents N,N-dimethyl propylene urea and n represents an integer of 1 to 4, then it is reacted with substituted aromatic iodide in a presence of copper (I) catalyst to obtain a trifluoromethyl group-containing compound.
Inventors:
MIKAMI KOICHI
NAKAMURA YUZO
NEGISHI KAZUYUKI
AIKAWA KOSUKE
NAKAMURA YUZO
NEGISHI KAZUYUKI
AIKAWA KOSUKE
Application Number:
JP2013032699A
Publication Date:
September 08, 2014
Filing Date:
February 22, 2013
Export Citation:
Assignee:
TOKYO INST TECH
TOSOH F TECH INC
TOSOH F TECH INC
International Classes:
C07F3/06; C07C67/307; C07C69/76; C07D213/61; C07B61/00
Domestic Patent References:
| JPS63303935A | 1988-12-12 | |||
| JP2013241345A | 2013-12-05 |
Other References:
JPN6016004324; Ｊｏｕｒｎａｌ ｏｆ Ｆｌｕｏｒｉｎｅ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１３１， Ｎｏ．２, 2010, ｐ．２１２-２１６
Attorney, Agent or Firm:
Katsufumi Mizuno
Masayuki Kishida
Hiroyuki Takano
Masayuki Kishida
Hiroyuki Takano