カリウムチャンネルモジュレーターとしてのCBXカンナビノイド受容体モジュレーターの使用

Japanese Patent JP2009534440

A

The invention is directed to the use of at least one CB_x modulator wherein the CB_x modulator is selected from the group consisting of CB₁ agonists; CB₂ agonists; CB₂ partial agonists; CB₂ antagonists; CB₂ inverse agonists; and dually acting compounds which are both a CB₁ agonist and a CB₂ agonist; and mixtures thereof, as K_ATP channel modulator for the prophylaxis, treatment, delayed progression, delayed onset and/or inhibition of a variety of disease conditions including obesity, diabetes mellitus, metabolic syndrome, syndrome X, insulinoma, familial hyperinsulemic hypoglycemia, male pattern baldness, detrusor hyperreactivity, asthma, neuroprotection, epilepsy, analgesia, cardioprotection, angina, cardioplegia, arrhythmia, coronary spasm, peripheral vascular disease, cerebral vasospasm, appetite regulation, neurodegeneration, pain - including neuropathic pain and chronic pain - and impotence in mammals and humans. The invention further relates to methods of treating, preventing, delaying progression of, delaying onset of and/or inhibiting a variety of disease conditions including obesity, diabetes mellitus, metabolic syndrome, syndrome X, insulinoma, familial hyperinsulemic hypoglycemia, male pattern baldness, detrusor hyperreactivity, asthma, neuroprotection, epilepsy, analgesia, cardioprotection, angina, cardioplegia, arrhythmia, coronary spasm, peripheral vascular disease, cerebral vasospasm, appetite regulation, neurodegeneration, pain - including neuropathic pain and chronic pain - and impotence in mammals and humans comprising administering to a subject in need thereof an effective amount of at least one CB_x modulator having K_ATP channel modulating properties.

WO/2005/123064	ADRENERGIC COMPLEMENT INHALER COMPRISING COMPOUNDS SUCH AS ASCORBATES TOCOPHEROLS OR POLYCABOXYLIC ACID CHELATORS
JP7041517	DNA aptamers that bind to cancer cells
JPH0474135	EYE DROP COMPOSITION

Jochen Antel
Peter-Colin Gregory
Josephus Hubertus Maria Lange
Michael Firunges
Dania Reiche

JP2009507043A

September 24, 2009

April 20, 2007

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Solvay Pharmaceuticals GmbH

A61K45/00; A61K31/05; A61K31/09; A61K31/10; A61K31/18; A61K31/352; A61K31/397; A61K31/404; A61K31/415; A61K31/4155; A61K31/4164; A61K31/4196; A61K31/422; A61K31/426; A61K31/4406; A61K31/4439; A61K31/454; A61K31/4545; A61K31/4704; A61K31/5025; A61K31/5377; A61K31/55; A61K31/557; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/06; A61P9/10; A61P9/12; A61P11/06; A61P15/10; A61P17/14; A61P19/06; A61P25/00; A61P25/04; A61P25/08; A61P35/00; A61P43/00; C07C43/23; C07C69/587; C07C313/04; C07C317/32; C07D205/06; C07D209/12; C07D231/06; C07D231/14; C07D233/64; C07D233/88; C07D233/90; C07D277/20; C07D277/56; C07D311/76; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/04; C07D403/12; C07D405/12; C07D413/04; C07D487/14; C07D498/06

Toshio Yano
Toshiomi Yamazaki
Takuya Kuno
Hiroshi Sugimoto
Kimihiro Hoshi
Hiroyasu Ninomiya
Einzel Felix-Reinhard
Reinhard Einsel

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