Title:
Chimeric antigen receptor that targets B cell maturation antigens
Document Type and Number:
Japanese Patent JP6359520
Kind Code:
B2
Abstract:
The invention provides an isolated and purified nucleic acid sequence encoding a chimeric antigen receptor (CAR) directed against B-cell Maturation Antigen (BCMA). The invention also provides host cells, such as T-cells or natural killer (NK) cells, expressing the CAR and methods for destroying multiple myeloma cells.
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Inventors:
Cofender Fur, James Noble
Application Number:
JP2015505765A
Publication Date:
July 18, 2018
Filing Date:
March 15, 2013
Export Citation:
Assignee:
THE UNITED STATES OF AMERICA
International Classes:
C12N15/13; A61K39/395; A61P35/00; C07K14/705; C07K16/28; C07K19/00; C12N5/10; C12N15/12
Domestic Patent References:
| JP2008540678A | ||||
| JP2012501180A |
Foreign References:
| US20070009518 | ||||
| US20110020343 | ||||
| US20110135639 | ||||
| WO2010104949A1 | ||||
| WO2012031744A1 |
Other References:
J. Immunother., 2009年,Vol.32, No.7,p.689-702 (引用した文献では、p.1-26)
Mol. Cancer Ther., 2007年,Vol.6, No.11,p.3009-3018
Blood, 2012年1月,Vol.119, No.1,p.72-82
J. Immunol., 2009年,Vol.183,p.5563-5574
J. Biomedicine and Biotechnology, 2010年,Vol. 2010, ID 956304,p.1-13
Mol. Cancer Ther., 2007年,Vol.6, No.11,p.3009-3018
Blood, 2012年1月,Vol.119, No.1,p.72-82
J. Immunol., 2009年,Vol.183,p.5563-5574
J. Biomedicine and Biotechnology, 2010年,Vol. 2010, ID 956304,p.1-13
Attorney, Agent or Firm:
Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Murata Miyuki
Junzo Koike
Hirofumi Toma
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Murata Miyuki
Junzo Koike
Hirofumi Toma