Title:
スーパーオキシドジスムターゼ-1の凝集を阻害する化合物
Document Type and Number:
Japanese Patent JP2008530241
Kind Code:
A
Abstract:
The invention is directed to methods of inhibiting the rate at which superoxide dismutse-1 (SOD) aggregates using compounds that stabilize SOD dimers. The methods are useful in the study and therapy of amyotrophic lateral sclerosis. The invention also includes assays that can be used to identify compounds that stabilize dimers and SOD molecules that have been modified for use in these assays.
Inventors:
Peter Lansbury
Andrew Che
Soumya Rei
Richard Nouck
Andrew Che
Soumya Rei
Richard Nouck
Application Number:
JP2007556363A
Publication Date:
August 07, 2008
Filing Date:
February 17, 2006
Export Citation:
Assignee:
The Briham and Women's Hospital, Incorporated
International Classes:
A61K31/055; A61K31/136; A61K31/16; A61K31/166; A61K31/4184; A61K31/426; A61K31/44; A61K31/513; A61K31/53; A61K31/57; A61K31/7076; A61P25/28; A61P43/00; C07D239/54; C07D253/06; C12N9/02; C12Q1/26; C07D213/73; C07D233/64; C07D277/10; C07H19/167; C07J7/00; C12N9/96; C12N15/09
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro