1-PIPERAZINOCARBOXYLATES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

WIPO Patent Application WO/1983/001950

A1

Diphenylbutyl-1-piperazinocarboxylates of the formula$(10,)$wherein R is alkyl straight or branch chained having from 1 to 10 carbon atoms, cycloalkyl having from 3 to 8 carbon atoms, aralkyl having from 7 to 9 carbon atoms or phenyl unsubstituted or substituted by one to three F, Cl, Br, lower alkyl having from 1 to 5 carbon atoms, lower alkoxy having from 1 to 5 carbon atoms, alkylenedioxy having from 1 to 3 carbon atoms, -CF3 or -CN substitutents, R1-R4 are independently H, CH3, C2H5 with cis or trans configuration provided that only two of them are other than hydrogen, and pharmaceutically acceptable salts thereof are described. Processes for their preparation are also described. The compounds are useful for treatment of mental disorders, such as aggression and psychosis in mammals.

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BJOERK ANDERS KARL KONRAD (SE)
CHRISTENSSON ERIK GUNNAR (SE)

PCT/SE1982/000408

June 09, 1983

November 30, 1982

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FERROSAN AB (SE)

A61K31/495; C07D241/08; C07D241/04; C07D295/18; C07D295/20; C07D295/205; C07D; (IPC1-7): C07D295/18; C07D241/04; A61K31/495

WO1981003658A1

1981-12-24

SE7908701A

Collection Czechoslov. Chem. Commun 1980, 45(11), 3182-89, published 10 March 1980
Arzneimittel-Forsch. Drug. Res. 27(1), No. 4, (1977) p. 828-832, W. MEULDERMANS, W. LAUWERS, A. KNAEPS, J. HEYKANTS; "In vitro metabolism of Lidoflazine by Rat and Dog Liver Fractions"
Chemical Abstracts, Vol. 85 (1976), abstract No. 33082m; & JP-A-51 008 283

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