The present invention relates to compounds of formula (I) which are galectin-3 inhibitors and their use in the prevention / prophylaxis or treatment of diseases and disorders that are related to galectin-3 binding to natural ligands. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more compounds of formula (I), and their medical use as Galectin-3 inhibitors. The compounds of formula (I)) may especially be used as single agents or in combination with one or more therapeutic agents.

Galectins are defined as a protein family based on conserved b-galactoside-binding sites found within their characteristic ~130 amino acid (aa) carbohydrate recognition domains (CRDs) (Barondes SH et al., Cell 1994; 76, 597-598). Human, mouse and rat genome sequences reveal the existence of at least 16 conserved galectins and galectin-like proteins in one mammalian genome (Leffler H. et al., Glycoconj. J. 2002, 19, 433-440). So far, three galectin subclasses were identified, the prototypical galectins containing one carbohydrate -recognition domain (CRD); the chimaera galectin consisting of unusual tandem repeats of proline- and glycine-rich short stretches fused onto the CRD; and the tandem -repeat -type galectins, containing two distinct CRDs in tandem connected by a linker (Zhong

X., Clin Exp Pharmacol Physiol. 2019; 46:197-203). As galectins can bind either bivalently or multivalently, they can e.g. cross-link cell surface glycoconjugates to trigger cellular signaling events. Through this mechanism, galectins modulate a wide variety of biological processes (Sundblad V. et al., Histol Histopathol 2011; 26: 247-265).

Galectin-3 (Gal-3), the only chimaera type in the galectin family, has a molecular weight of 32-35 kDa and consists of 250 amino acid residues in humans, a highly conserved CRD and an atypical N- terminal domain (ND). Galectin-3 is monomeric up to high concentrations (100 mM), but can aggregate with ligands at much lower concentrations, which is promoted by its N-terminal non-CRD region via an oligomerisation mechanism that is not yet completely understood (Johannes, L. et al., Journal of Cell Science 2018; 131, jcs208884).

Gal-3 is widely distributed in the body, but the expression level varies among different organs. Depending on its extracellular or intracellular localization, it can display a broad diversity of biological functions, including immunomodulation, host-pathogen interactions, angiogenesis, cell migration, wound healing and apoptosis (Sundblad V. et al., Histol Histopathol 2011; 26: 247-265). Gal-3 is highly expressed in many human tumours and cell types, such as myeloid cells, inflammatory cells (macrophages, mast cells, neutrophils, T cells, eosinophils, etc.), fibroblasts and cardiomyocytes (Zhong X. et al., Clin Exp Pharmacol Physiol. 2019; 46:197-203), indicating that Gal-3 is involved in the regulation of inflammatory and fibrotic processes (Henderson NC. Et al., Immunological Reviews 2009; 230: 160- 171; Sano H. et al., J Immunol. 2000; 165(4):2156-64). Furthermore, Gal-3 protein expression levels are up-regulated under certain pathological conditions, such as neoplasms and inflammation (Chiariotti L. et al., Glycoconjugate Journal 2004 19, 441-449; Farhad M. et al., Oncolmmunology 2018, 7:6, e1434467).

There are multiple lines of evidence supporting functional involvement of Gal-3 in the development of inflammatory / autoimmune diseases, such as asthma (Gao P. et al. Respir Res. 2013, 14:136; Rao SP et al. Front Med (Lausanne) 2017; 4:68), rheumatoid arthritis, multiple sclerosis, diabetes, plaque psoriasis (Lacina L. et al. Folia Biol (Praha) 2006; 52(1-2): 10-5) atopic dermatitis (Saegusa J. et al. Am J Pathol. 2009, 174(3):922-31), endometriosis (Noel JC et al. Appl Immunohistochem Mol Morphol. 2011 19(3):253-7), or viral encephalitis (Liu FT et al., Ann N Y Acad Sci. 2012; 1253:80-91; Henderson NC, et al., Immunol Rev. 2009;230(1 ): 160-71 ; Li P et al.,Cell 2016; 167:973-984). Recently Gal-3 has emerged as a key player of chronic inflammation and organ fibrogenesis development e.g. liver ( Henderson NC et al., PNAS 2006; 103: 5060-5065; Hsu DK et al. Int J Cancer. 1999, 81 (4):519-26), kidney (Henderson NC et al., Am. J. Pathol. 2008; 172:288-298; Dang Z. et al. Transplantation. 2012, 93(5):477-84), lung (Mackinnon AC et al., Am. J. Respir. Crit. Care Med 2012, 185: 537-546; Nishi Y. et al. Allergol Int. 2007, 56(1):57-65), heart (Thandavarayan RA et al. Biochem Pharmacol. 2008, 75(9): 1797-806; Sharma U. et al. Am J Physiol Heart Circ Physiol. 2008; 294(3): H 1226-32), as well as the nervous system (Burguillos MAet al. Cell Rep. 2015, 10(9): 1626-1638), and in corneal neovascularization (Chen WS. Et al., Investigative Ophthalmology & Visual Science 2017, Vol.58, 9-20). Additionally, Gal-3 was found to be associated with dermal thickening of keloid tissues (Arciniegas E. et al., The American Journal of dermatopathology 2019; 41 (3): 193-204) and systemic sclerosis (SSc) especially with skin fibrosis and proliferative vasculopathy observed in such condition (Taniguchi T. et al. J Rheumatol. 2012, 39(3):539-44). Gal-3 was found to be up-regulated in patient suffering chronic kidney disease (CKD) associated-kidney failure, and especially in those affected by diabetes. Interestingly, data obtained from this patient population showed correlation between Gal-3 upregulation in glomeruli and the observed urinary protein excretion (Kikuchi Y. et al. Nephrol Dial Transplant. 2004, 19(3):602-7). Additionally, a recent prospective study from 2018 demonstrated that higher Gal-3 plasma levels are associated with an elevated risk of developing incident CKD, particularly among hypertension-suffering population (Rebholz CM. et al. Kidney Int. 2018 Jan; 93(1): 252-259). Gal-3 is highly elevated in cardiovascular diseases (Zhong X. et al. Clin Exp Pharmacol Physiol. 2019, 46(3): 197-203), such as atherosclerosis (Nachtigal M. et al. Am J Pathol. 1998; 152(5): 1199-208), coronary artery disease (Falcone C. et al. Int J Immunopathol Pharmacol 2011, 24(4):905- 13), heart failure and thrombosis (Nachtigal M. et al., Am J Pathol. 1998; 152 (5): 1199-208; Gehlken C. et al., Heart Fail Clin. 2018,14(1)75-92; DeRoo EP. et al., Blood. 2015, 125(11):1813-21). Gal-3 blood concentration is elevated in obese and diabetic patients and is associated with a higher risk for micro- and macro- vascular complication (such as heart failure, nephropathy/retinopathy, peripheral arterial disease, cerebrovascular event, or myocardial infarction) (Qi- hui-Jin et al. Chin Med J (Engl). 2013,126(11):2109-15). Gal-3 influences oncogenesis, cancer progression, and metastasis (Vuong L. et al., Cancer Res 2019 (79) (7) 1480-1492), and was shown to exert a role as a pro-tumor factor by acting within the micro tumor environment to suppress immune surveillance (Ruvolo PP. et al. Biochim Biophys Acta. 2016 M ar, 1863(3) : 427-437 ; Farhad M. et al. Oncoimmunology 2018 Feb 20;7(6):e1434467). Among the cancers that express high level of Gal-3 are found those affecting the thyroid gland, the central nervous system, the tongue, the breast, the gastric cancer, the head and neck squamous cell, the pancreas, the bladder, the kidney, the liver, the parathyroid, the salivary glands, but also lymphoma, carcinoma, non-small cell lung cancer, melanoma and neuroblastoma (Sciacchitano S. et al. Int J Mol Sci 2018 Jan 26,19(2):379).

Also, Gal-3 inhibition has been proposed to be beneficial in the treatment of COVID-19 (Caniglia JL et al.PeerJ 2020, 8:e9392) and influenza H5N1 (Chen YJ et al. Am. J. Pathol. 2018, 188(4), 1031-1042) possibly due to anti- inflammatory effects.

Recently, Gal-3 inhibitors have shown to have positive effects when used in combination immunotherapy (Galectin Therapeutics. Press Release, February 7, 2017) and idiopathic pulmonary fibrosis (Galecto Biotech. Press Release, March 10, 2017) and in NASH cirrhosis (December 05, 2017). WO20180209276, WO2018209255 and WO20190890080 disclose compounds having binding affinity with galectin proteins for the treatment of systemic insulin resistance disorders. Thus, Gal-3 inhibitors, alone or in combination with other therapies, may be useful for the prevention or treatment of diseases or disorders such as fibrosis of organs, cardiovascular diseases and disorders, acute kidney injury and chronic kidney disease, liver diseases and disorders, interstitial lung diseases and disorders, ocular diseases and disorders, cell proliferative diseases and cancers, inflammatory and autoimmune diseases and disorders, gastrointestinal tract diseases and disorders, pancreatic diseases and disorders, abnormal angiogenesis- associated diseases and disorders, brain-associated diseases and disorders, neuropathic pain and peripheral neuropathy, and / or transplant rejection.

Several publications and patent applications describe synthetic inhibitors of Gal-3 that are being explored as antifibrotic agents (see for example WO2005113568, WO2005113569, WO2014067986, WO2016120403, US20140099319, WO2019067702, WO2019075045, WO2014078655, WO2020078807 and WO2020078808).

The present invention provides novel compounds of formula (I) which are Galectin-3 inhibitors. The present compounds may, thus, be useful for the prevention / prophylaxis or treatment of diseases and disorders where modulation of Gal- 3 binding to its natural carbohydrate ligands is indicated.

1) In a first embodiment, the invention relates to a compound of the Formula (I), wherein n represents the integer 1 or 2 (especially n is 1);

Ar ¹ represents

• aryl (especially phenyl) which is mono-, di-, tri-, tetra-, or penta-substituted (especially mono-, di-, or tri-substituted), wherein the substituents are independently selected from halogen; methyl; cyano; methoxy; trifluoromethyl; trifluoromethoxy; NR ^N11 R ^N12 wherein R ^N11 represents hydrogen and R ^N12 represents hy droxy-C _2-3 -alkyI (especially 3-hydroxy-prop1-yl), or R ^N11 and R ^N12 together with the nitrogen atom to which they are attached form a 4- to 6- membered heterocyclyl selected from morpholin-4-yl, azetidine-1-yl, pyrrolidine-1-yl, and piperidine-1-yl (especially morpholin-4-yl), wherein said 4- to 6-membered heterocyclyl is unsubstituted or mono-substituted with hydroxy (notably selected from halogen, methyl, cyano, and methoxy) ;

[wherein in particular at least one of said substituents is attached in a meta-, or in para-position of said phenyl; wherein, if present, such substituent in para-position is preferably selected from halogen, methyl, cyano, and methoxy; and, if present, such substituent in meta-position is preferably halogen];

• 5- or 6-membered heteroaryl (especially thiazolyl), wherein said 5- or 6-membered heteroaryl independently is unsubstituted, mono- or di-substituted, wherein the substituents are independently selected from halogen, methyl, cyano, and methoxy; or

• 9- or 10-membered heteroaryl (especially benzothiazolyl), wherein said 9- or 10-membered heteroaryl independently is unsubstituted, or mono-substituted with methyl;

R ¹ represents

• hydroxy;

• C _1-3 -alkoxy (especially methoxy); • -O-CO-C _1-3 -alkyI ;

• -O-CH ₂ --CH ₂ --OH; or

• -O-CH ₂ -CO-R ^1x wherein R ^1x represents

> -hydroxy;

> morpholin-4-yl; or

> -NR ^N21 R ^N22 , wherein R ^N21 and R ^N22 together with the nitrogen atom to which they are attached form a 4- to 6-membered heterocyclyl selected from azetidine-1-yl, pyrrolidine-1-yl, and piperidine-1-yl, wherein said 4- to 6-membered heterocyclyl is mono-substituted with hydroxy;

L represents a direct bond, methylene, or ethylene (especially a direct bond or methylene); and

Ar ² represents

• phenyl or 5- or 6-membered heteroaryl (especially furanyl, thiophenyl, pyrrolyl, thiazolyl, isothiazolyl, isoxazolyl, pyrazolyl, imidazolyl, pyridinyl, or pyrimidinyl), wherein said phenyl or 5- or 6-membered heteroaryl independently is unsubstituted, or mono-, di- or tri-substituted (notably mono-, or di-substituted) wherein the substituents independently are selected from C _1-6 -alkyl, C _3-6 -cycloalkyl, -CH ₂ -- C _3-6 -cycloalkyl, C _1-3 -fluoroalkyl, C _1-3 -fIuoroalkoxy , C _1-3 -alkoxy, halogen, morpholine-4-yl, amino, ethynyl and cyano;

• 9-membered bicyclic heteroaryl (especially indolyl, or benzothiophenyl, benzothiazolyl, or benzoimidazolyl) or 10- membered bicyclic heteroaryl (especially quinolinyl or quinoxalinyl), wherein said 9- or 10-membered bicyclic heteroaryl independently is unsubstituted, mono- or di-substituted, wherein the substituents independently are selected from methyl, methoxy, and halogen (especially fluoro, chloro); or

• naphthyl.

The compounds of Formula (I) contain five stereogenic or asymmetric centers, which are situated on the tetrahydropyran moiety, and two stereogenic or asymmetric centers situated on the cycloalkane moiety which are in the absolute (S,S)-configuration as drawn for Formula (I). In addition, the compounds of Formula (I) may contain one, and possibly more stereogenic or asymmetric centers, such as one or more additional asymmetric carbon atoms. The compounds of Formula (I) may thus be present as mixtures of stereoisomers or preferably as pure stereoisomers. Mixtures of stereoisomers may be separated in a manner known to a person skilled in the art.

In case a particular compound (or generic structure) is designated as being in a certain absolute configuration, e.g. as (R)- or (S)-enantiomer, such designation is to be understood as referring to the respective compound (or generic structure) in enriched, especially essentially pure, enantiomeric form. Likewise, in case a specific asymmetric center in a compound is designated as being in (R)- or (S)-configuration or as being in a certain relative configuration, such designation is to be understood as referring to the compound that is in enriched, especially essentially pure, form with regard to the respective configuration of said asymmetric center. In analogy, two stereogenic centers e.g in a cyclic group may be present in a certain relative configuration. Accordingly, cis- or trans-designations (or (R* R*) designations as used e.g. for certain intermediates of the present compounds) are to be understood as referring to the respective stereoisomer of the respective relative configuration in enriched form, especially in essentially pure form. Thus, for a given molecule or group, the designation (R*,R*), if not explicitly specified otherwise, includes the respective (R,R)- enantiomer, the (S,S)-enantiomer, and any mixture of these two enantiomers including the racemate.

The term "enriched", when used in the context of stereoisomers, is to be understood in the context of the present invention to mean that the respective stereoisomer is present in a ratio of at least 70:30, especially of at least 90:10 (i.e., in a purity of at least 70% by weight, especially of at least 90% by weight), with regard to the respective other stereoisomer / the entirety of the respective other stereoisomers.

The term "essentially pure”, when used in the context of stereoisomers, is to be understood in the context of the present invention to mean that the respective stereoisomer is present in a purity of at least 95% by weight, especially of at least 99% by weight, with regard to the respective other stereoisomer / the entirety of the respective other stereoisomers.

The present invention also includes isotopically labelled, especially ² H (deuterium) labelled compounds of Formula (I) according to embodiments 1) to 20), which compounds are identical to the compounds of Formula (I) except that one or more atoms have each been replaced by an atom having the same atomic number but an atomic mass different from the atomic mass usually found in nature. Isotopically labelled, especially ² H (deuterium) labelled compounds of formulae (I), (II) and (III) and salts thereof are within the scope of the present invention. Substitution of hydrogen with the heavier isotope ² H (deuterium) may lead to greater metabolic stability, resulting e.g. in increased in-vivo half-life or reduced dosage requirements, or may lead to reduced inhibition of cytochrome P450 enzymes, resulting e.g. in an improved safety profile. In one embodiment of the invention, the compounds of Formula (I) are not isotopically labelled, or they are labelled only with one or more deuterium atoms. In a sub-embodiment, the compounds of Formula (I) are not isotopically labelled at all. Isotopically labelled compounds of Formula (I) may be prepared in analogy to the methods described hereinafter, but using the appropriate isotopic variation of suitable reagents or starting materials.

In this patent application, a bond drawn as a dotted line shows the point of attachment of the radical drawn. For example, the radical drawn below is a 3-fluorophenyl group.

Where the plural form is used for compounds, salts, pharmaceutical compositions, diseases and the like, this is intended to mean also a single compound, salt, or the like. Any reference to compounds of Formula (I) according to embodiments 1) to 20) is to be understood as referring also to the salts (and especially the pharmaceutically acceptable salts) of such compounds, as appropriate and expedient.

The term "pharmaceutically acceptable salts" refers to salts that retain the desired biological activity of the subject compound and exhibit minimal undesired toxicological effects. Such salts include inorganic or organic acid and/or base addition salts depending on the presence of basic and/or acidic groups in the subject compound. For reference see for example "Handbook of Pharmaceutical Salts. Properties, Selection and Use.”, P. Heinrich Stahl, Camille G. Wermuth (Eds.), Wiley-VCH, 2008; and "Pharmaceutical Salts and Co-crystals”, Johan Wouters and Luc Quere (Eds.), RSC Publishing, 2012.

Definitions provided herein are intended to apply uniformly to the compounds of Formula (I), as defined in any one of embodiments 1) to 18), and, mutatis mutandis, throughout the description and the claims unless an otherwise expressly set out definition provides a broader or narrower definition. It is well understood that a definition or preferred definition of a term defines and may replace the respective term independently of (and in combination with) any definition or preferred definition of any or all other terms as defined herein.

In this patent application, the compounds are named using lUPAC nomenclature, but can also be named using carbohydrate nomenclature. Thus, the moiety: can be named (2R,3R,4S,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-(4-phenyl -1H-1,2,3-triazol-1-yl)tetrahydro-2H- pyran-2-carbonyl or, alternatively, 1,3-di-deoxy-3-[4-phenyl-1H-1, 2, 3-triazol-1-yl]-b-D-galactopyranoside-1 -carbonyl, wherein the absolute configuration of carbon atom carrying the carbonyl group which is the point of attachment to the rest of the molecule is in (2R)- , respectively, beta-configuration. For example, compound (2R,3R,4S,5R,6R)-5- hydroxy-N-((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3- methoxy-N-((1-methyl-1H-pyrrol-2-yl)methyl)-4-(4- (3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yI)tetrahydro-2H- pyran-2-carboxamide is to be understood as also referring to: 1,3-di-deoxy-2-O-methyl-3-[4-(3,4,5-trifluorophenyl)-1H-1,2, 3-triazol-1-yl]-(N-((1-methyl-1H-pyrrol-2-yl)methyl)-N- ((1S,2S)-2-hydroxycyclohexyl))-b-D-galacto-pyranose-1-carbox amide. Whenever a substituent is denoted as optional, it is understood that such substituent may be absent (i.e. the respective residue is unsubstituted with regard to such optional substituent), in which case all positions having a free valency (to which such optional substituent could have been attached to; such as for example in an aromatic ring the ring carbon atoms and / or the ring nitrogen atoms having a free valency) are substituted with hydrogen where appropriate. Likewise, in case the term "optionally” is used in the context of (ring) heteroatom(s), the term means that either the respective optional heteroatom (s), or the like, are absent (i.e. a certain moiety does not contain heteroatom(s) / is a carbocycle / or the like), or the respective optional heteroatom (s), or the like, are present as explicitly defined. If not explicitly defined otherwise in the respective embodiment or claim, groups defined herein are unsubstituted.

The term "halogen” means fluorine, chlorine, or bromine, preferably fluorine or chlorine.

The term "alkyl”, used alone or in combination, refers to a saturated straight or branched chain hydrocarbon group containing one to six carbon atoms. The term “C _x-y -alkyl” (x and y each being an integer), refers to an alkyl group as defined before, containing x to y carbon atoms. For example, a C _1-6 -alkyl group contains from one to six carbon atoms. Representative examples of alkyl groups are methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert.-butyl, pentyl, 3-methyl- butyl, 2,2-dimethyl-propyl and 3,3-dimethyl-butyl. Preferred is methyl. For avoidance of any doubt, in case a group is referred to as e.g. propyl or butyl, it is meant to be n-propyl, respectively n-butyl. In case the substituent of Ar ² (being phenyl or 5- or 6-membered heteroaryl) represents “ C _1-6 -alkyl”, the term especially refers to methyl, ethyl, or isopropyl; in particular to methyl.

The term "-C _x-y -alkylene-”, used alone or in combination, refers to bivalently bound alkyl group as defined before containing x to y carbon atoms. The term "-C _0-y -alkylene-" refers to a direct bond, or to a -(C _1-y )alkylene- as defined before. Preferably, the points of attachment of a -C _1-y -alkylene group are in 1,1-diyl, or in 1,2-diyl, or in 1,3-diyl arrangement. Preferably, the points of attachment of a -C _2-y -alkylene group are in 1,2-diyl or in 1,3-diyl arrangement. In case a C _{0 y} -alkylene group is used in combination with another substituent, the term means that either said substituent is linked through a Ci _y -alkylene group to the rest of the molecule, or it is directly attached to the rest of the molecule (i.e. a C ₀ -alkylene group represents a direct bond linking said substituent to the rest of the molecule). The alkylene group -C ₂ H ₄ - (or ethylene) refers to -CH ₂ -CH ₂ - if not explicitly indicated otherwise.

The term "alkenyl", used alone or in combination, refers to a straight or branched hydrocarbon chain containing two to five carbon atoms and one carbon-carbon double bond. The term "C _x-y -alkenyl" (x and y each being an integer), refers to an alkenyl group as defined before containing x to y carbon atoms. For example, a C _2-5 -alkenyl group contains from two to five carbon atoms.

The term "fluoroalkyl”, used alone or in combination, refers to an alkyl group as defined before containing one to three carbon atoms in which one or more (and possibly all) hydrogen atoms have been replaced with fluorine. The term "C _{x- y} -fluoroal kyl” (x and y each being an integer) refers to a fluoroalkyl group as defined before containing x to y carbon atoms. For example, a C _1-3 -fluoroalkyl group contains from one to three carbon atoms in which one to seven hydrogen atoms have been replaced with fluorine. Representative examples of fluoroalkyl groups include trifluoromethyl, 2- fluoroethyl, 2,2-difluoroethyl and 2,2,2-trifluoroethyl. Preferred is trifluoromethyl.

The term "fluoroalkoxy”, used alone or in combination, refers to an alkoxy group as defined before containing one to three carbon atoms in which one or more (and possibly all) hydrogen atoms have been replaced with fluorine. The term "C _x-y -fluoroalkoxy” (x and y each being an integer) refers to a fluoroalkoxy group as defined before containing x to y carbon atoms. For example, a C _1-3 -fIuoroalkoxy group contains from one to three carbon atoms in which one to seven hydrogen atoms have been replaced with fluorine. Representative examples of fluoroalkoxy groups include trifluoromethoxy, difluoromethoxy, 2-fluoroethoxy, 2,2-difluoroethoxy and 2,2,2-trifluoroethoxy.

The term "cycloalkyl", used alone or in combination, refers especially to a saturated monocyclic, or to a fused-, bridged-, or spiro-bicyclic hydrocarbon ring containing three to eight carbon atoms. The term "C _x-y -cycloal kyl" (x and y each being an integer), refers to a cycloalkyl group as defined before containing x to y carbon atoms. For example, a C _3-6 -cycloalkyl group contains from three to six carbon atoms. Examples of cycloalkyl groups are cyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl. Preferred is cyclopropyl.

The term "alkoxy”, used alone or in combination, refers to an alkyl-O- group wherein the alkyl group is as defined before. The term "C _x-y -alkoxy” (x and y each being an integer) refers to an alkoxy group as defined before containing x to y carbon atoms. Preferred are ethoxy and especially methoxy. In case R ¹ represents " C _1-3 -alkoxy” the term especially refers to methoxy. In case the substituent of Ar ² (being phenyl or 5- or 6-membered heteroaryl) represents "C _1-3 -alkoxy”, the term especially refers to methoxy.

The term "heterocyclyl”, used alone or in combination, and if not explicitly defined in a broader or more narrow way, refers to a saturated or unsaturated non-aromatic monocyclic hydrocarbon ring containing one or two ring heteroatoms independently selected from nitrogen, sulfur, and oxygen (especially one oxygen atom, one sulfur atom, one nitrogen atom, two nitrogen atoms, two oxygen atoms, one nitrogen atom and one oxygen atom). The term "C _x-y -heterocyclyl” refers to such a heterocycle containing x to y ring atoms. Heterocyclyl groups are unsubstituted or substituted as explicitly defined.

The term "aryl", used alone or in combination, means phenyl or naphthyl, preferably phenyl, wherein said aryl group is unsubstituted or substituted as explicitly defined.

The term "heteroaryl", used alone or in combination, and if not explicitly defined in a broader or more narrow way, means a 5- to 10-membered monocyclic or bicyclic aromatic ring containing one to a maximum of four heteroatoms, each independently selected from oxygen, nitrogen and sulfur. Representative examples of such heteroaryl groups are 5-membered heteroaryl groups such as furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thiophenyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl; 6-membered heteroaryl groups such as pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl; and 8- to 10-membered bicyclic heteroaryl groups such as indolyl, isoindolyl, benzofuranyl, isobenzofuranyl, benzothiophenyl, indazolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzoisothiazolyl, benzotriazolyl, benzoxadiazolyl, benzothiadiazolyl, thienopyridinyl, quinolinyl, isoquinolinyl, naphthyridinyl, cinnolinyl, quinazolinyl, quinoxalinyl, phthal azinyl, pyrrolopyridinyl, pyrazolopyridinyl, pyrazolopyrimidinyl, pyrrol opyrazi nyl , imidazopyridinyl, imidazopyridazinyl, and imidazothiazolyl. The above-mentioned heteroaryl groups are unsubstituted or substituted as explicitly defined. For the substituent Ar ² representing "5- or 6- membered heteroaryl", the term especially means furanyl, thiophenyl, pyrrolyl, thiazolyl, isothiazolyl, isoxazolyl, pyrazolyl, imidazolyl, pyridinyl, or pyrimidinyl; notably furan-2-yl, thiophen-2-yl, thiophen-3-yl, 1H-pyrrol-2-yl, thiazol-2- yl, thiazol-4-yl, thiazol-5-yl, isothiazol-4-yl, isothiazol-5-yl, isoxazol-4-yl, 1H-pyrazol-3-yl, 1H-pyrazol-5-yl, 1H-imidazol- 2-yl, 1H-imidazol-4-yl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, or pyrimidin-5-yl. For the substituent Ar ² representing "9- membered bicyclic heteroaryl", the term especially means indolyl; or, in addition benzothiophenyl, benzothiazolyl, or benzoimidazolyl; notably 1H-indol-2-yl; or, in addition, benzothiophen-6-yl, benzothiazol-6-yl, benzoth i azol-5-y I , or benzoimidazol-6-yl; wherein said 9-membered bicyclic heteroaryl is unsubstituted or substituted as explicitly defined; a particular example is 1-methyl-1H-indol-2-yl. For the substituent Ar ² representing "10-membered bicyclic heteroaryl", the term especially means quinolinyl or quinoxalinyl; notably quinoline-2-yl, or quinoxaline-5-yl.

The term "cyano" refers to a group -CN.

Whenever the word "between” is used to describe a numerical range, it is to be understood that the end points of the indicated range are explicitly included in the range. For example: if a temperature range is described to be between 40 °C and 80 °C, this means that the end points 40 °C and 80 °C are included in the range; or if a variable is defined as being an integer between 1 and 4, this means that the variable is the integer 1, 2, 3, or 4.

Unless used regarding temperatures, the term "about” placed before a numerical value "X” refers in the current application to an interval extending from X minus 10% of X to X plus 10% of X, and preferably to an interval extending from X minus 5% of X to X plus 5% of X. In the particular case of temperatures, the term "about” placed before a temperature “Y" refers in the current application to an interval extending from the temperature Y minus 10°C to Y plus 10°C, and preferably to an interval extending from Y minus 5°C to Y plus 5°C. Besides, the term "room temperature” as used herein refers to a temperature of about 25°C.

Further embodiments of the invention are presented hereinafter:

2) A second embodiment relates to compounds according to embodiment 1), wherein Ar ¹ represents a phenyl which is mono-, di- or tri-substituted, wherein the substituents are independently selected from halogen, methyl, cyano, and methoxy; wherein at least one of said substituents is attached in a meta- or in para- position of said phenyl, > wherein, if present, the substituent in para- position is preferably selected from halogen, methyl, cyano, and methoxy; and

> wherein, if present, the substituent in meta-position is preferably halogen.

3) Another embodiment relates to compounds according to embodiment 1), wherein Ar ¹ represents phenyl which is mono-, di- or tri-substituted, wherein

> one of said substituents is attached in meta-position of said phenyl, wherein said substituent is halogen; and the remaining substituent(s), if present, is / are halogen (especially fluoro); or

> one of said substituents is attached in para- position of said phenyl, wherein said substituent is independently selected from methyl, cyano, and methoxy; and the remaining substituent(s), if present, is / are halogen (especially fluoro).

4) Another embodiment relates to compounds according to embodiment 1), wherein Ar ¹ represents a phenyl group of the structure wherein

> R ^o1 represents hydrogen, fluoro, methyl, methoxy or trifluoromethyl;

> R ^m1 represents hydrogen or halogen;

> R ^P represents hydrogen, halogen, methyl, cyano, 3-hydroxyprop-1-yl or morpholin-4-yl; and

> R ^m2 represents hydrogen, halogen, methyl, methoxy or trifluoromethoxy.

5) Another embodiment relates to compounds according to embodiment 1), wherein Ar ¹ represents a phenyl group of the structure wherein

> R ^m2 represents hydrogen or fluoro; and R ^p represents independently halogen (especially fluoro or chloro), methyl, cyano, or methoxy (notably R ^p represents fluoro, chloro, or methyl); or

> R ^m2 represents hydrogen or fluoro; and R ^p represents hydrogen. 6) Another embodiment relates to compounds according to embodiment 1), wherein Ar ¹ represents a phenyl group of the structure wherein

> R ^m2 represents halogen (especially fluoro); and

> R ^p represents hydrogen, halogen (especially fluoro or chloro), methyl, cyano, or methoxy (notably R ^p represents fluoro, chloro, or methyl).

7) Another embodiment relates to compounds according to embodiment 1), wherein Ar ¹ represents

A) wherein each of the groups A) to C) form a particular sub-embodiment; and wherein group A) forms another sub- embodiment.

8) Another embodiment relates to compounds according to any one of embodiments 1) to 7), wherein R ¹ represents

• hydroxy;

• methoxy; or

• -O-CH ₂ -CO-R ^1x wherein R ^1x represents

> -hydroxy;

> morpholin-4-yl; or

9) Another embodiment relates to compounds according to any one of embodiments 1) to 7), wherein R ¹ represents hydroxy.

10) Another embodiment relates to compounds according to any one of embodiments 1) to 7), wherein R ¹ represents methoxy.

11) Another embodiment relates to compounds according to any one of embodiments 1) to 10), wherein L represents methylene.

12) Another embodiment relates to compounds according to any one of embodiments 1) to 10), wherein L represents a direct bond.

13) Another embodiment relates to compounds according to any one of embodiments 1) to 12), wherein Ar ² represents

• phenyl which is unsubstituted, mono-, or di-substituted wherein the substituents independently are selected from C _1-4 -alkyl (especially methyl), C _1-3 -fluoroalkyl (especially trifluoromethyl), C _1-3 -alkoxy (especially methoxy), halogen (especially fluoro or chloro), ethynyl, and cyano; or

• 5- or 6-membered heteroaryl (especially furanyl, thiophenyl, pyrrolyl, thiazolyl, isothiazolyl, isoxazolyl, pyrazolyl, imidazolyl, pyridinyl, or pyrimidinyl), wherein said 5- or 6-membered heteroaryl independently is unsubstituted, mono-, or di-substituted wherein the substituents independently are selected from C _1-4 -alkyl (especially methyl), - CH ₂ --C _3-6 -cycloalkyl (especially - CH ₂ -cyclopropyl), C _1-3 -fluoroalkyl (especially trifluoromethyl), C _1-3 -alkoxy (especially methoxy), halogen (especially fluoro or chloro), morpholine-4-yl, and amino.

14) Another embodiment relates to compounds according to any one of embodiments 1) to 12), wherein Ar ² represents:

• phenyl which is unsubstituted, mono-, or di-substituted wherein the substituents independently are selected from C _1-4 -alkyl (especially methyl), C _1-3 -fluoroalkyl (especially trifluoromethyl), C _1-3 -alkoxy (especially methoxy), halogen (especially fluoro or chloro) and cyano; or • a 5- or 6-membered heteroaryl (especially thiophenyl, pyrrolyl, isothiazolyl, pyrazolyl, pyridinyl, or pyrimidinyl), wherein said 5- or 6-membered heteroaryl independently is unsubstituted, mono-, or di-substituted wherein the substituents independently are selected from C _1-4 -alkyl (especially methyl), -CH ₂ --C _3-6 -cycloalkyl (especially -CH ₂ - cyclopropyl), C _1-3 -fluoroalkyl (especially trifluoromethyl), C _1-3 -alkoxy (especially methoxy), halogen (especially fluoro or chloro), and morpholine-4-yI .

15) Another embodiment relates to compounds according to any one of embodiments 1) to 12), wherein Ar ² represents:

• phenyl which is mono-, or di-substituted wherein the substituents independently are selected from C _1-3 -fluoroalkyl (especially trifluoromethyl), and halogen; or a 5- or 6-membered heteroaryl (especially thiophenyl, pyrrolyl, pyrazolyl, pyridinyl, or pyrimidinyl), wherein said 5- or 6-membered heteroaryl independently is mono-, or di-substituted wherein the substituents independently are selected from C _1-4 -alkyl (especially methyl), and C _1-3 -fluoroalkyl (especially trifluoromethyl).

16) Another embodiment relates to compounds according to any one of embodiments 1) to 10), wherein the fragment -L-Ar ² represents:

wherein each of the groups A) to H) form a particular sub-embodiment; and wherein another sub-embodiment refers to groups A), B), and / or C).

17) Another embodiment relates to compounds according to any one of embodiments 1) to 16), wherein n represents the integer 1.

18) The invention, thus, relates to compounds of the Formula (I) as defined in embodiment 1), or to such compounds further limited by the characteristics of any one of embodiments 2) to 17), under consideration of their respective dependencies; to pharmaceutically acceptable salts thereof; and to the use of such compounds as further described herein below. For avoidance of any doubt, especially the following embodiments relating to the compounds of Formula (I) are thus possible and intended and herewith specifically disclosed in individualized form:

1, 2+1, 3+1, 4+1, 5+1, 6+1, 7+1, 8+1, 8+2+1, 8+3+1, 8+4+1, 8+5+1, 8+6+1, 8+7+1, 9+1, 9+2+1, 9+3+1, 9+4+1, 9+5+1 9+6+1 , 9+7+1 , 10+1, 10+2+1 , 10+3+1 , 10+4+1 , 10+5+1 , 10+6+1 , 10+7+1 , 11+1, 11+2+1, 11+3+1, 11+4+1, 11 +5+1 11+6+1, 11+7+1, 11+8+1, 11+8+2+1, 11+8+3+1, 11+8+4+1, 11+8+5+1, 11+8+6+1, 11+8+7+1, 11+9+1, 11+9+2+1, 11 +9+3+1 , 11 +9+4+1 , 11 +9+5+1 , 11 +9+6+1 , 11 +9+7+1 , 11+10+1, 11+10+2+1 , 11+10+3+1 , 11+10+4+1 , 11+10+5+1 , 11+10+6+1, 11+10+7+1, 12+1, 12+2+1, 12+3+1, 12+4+1, 12+5+1, 12+6+1, 12+7+1, 12+8+1, 12+8+2+1, 12+8+3+1, 12+8+4+1, 12+8+5+1, 12+8+6+1, 12+8+7+1, 12+9+1, 12+9+2+1, 12+9+3+1, 12+9+4+1, 12+9+5+1, 12+9+6+1, 12+9+7+1, 12+10+1, 12+10+2+1, 12+10+3+1, 12+10+4+1, 12+10+5+1, 12+10+6+1, 12+10+7+1, 13+1, 13+2+1, 13+3+1, 13+4+1, 13+5+1, 13+6+1, 13+7+1, 13+8+1, 13+8+2+1, 13+8+3+1, 13+8+4+1, 13+8+5+1, 13+8+6+1, 13+8+7+1, 13+9+1, 13+9+2+1, 13+9+3+1, 13+9+4+1, 13+9+5+1, 13+9+6+1, 13+9+7+1, 13+10+1, 13+10+2+1, 13+10+3+1, 13+10+4+1, 13+10+5+1, 13+10+6+1, 13+10+7+1, 13+11+1, 13+11+2+1, 13+11+3+1, 13+11+4+1, 13+11+5+1, 13+11+6+1, 13+11+7+1, 13+11+8+1, 13+11+8+2+1, 13+11+8+3+1, 13+11+8+4+1, 13+11+8+5+1, 13+11+8+6+1, 13+11+8+7+1, 13+11+9+1, 13+11+9+2+1, 13+11+9+3+1, 13+11+9+4+1, 13+11+9+5+1,

13+11+9+6+1, 13+11+9+7+1, 13+11+10+1, 13+11+10+2+1, 13+11+10+3+1, 13+11+10+4+1, 13+11+10+5+1, 13+11+10+6+1, 13+11+10+7+1, 13+12+1, 13+12+2+1, 13+12+3+1, 13+12+4+1, 13+12+5+1, 13+12+6+1, 13+12+7+1, 13+12+8+1, 13+12+8+2+1, 13+12+8+3+1, 13+12+8+4+1, 13+12+8+5+1, 13+12+8+6+1, 13+12+8+7+1, 13+12+9+1, 13+12+9+2+1, 13+12+9+3+1, 13+12+9+4+1, 13+12+9+5+1, 13+12+9+6+1, 13+12+9+7+1, 13+12+10+1, 13+12+10+2+1, 13+12+10+3+1, 13+12+10+4+1, 13+12+10+5+1, 13+12+10+6+1, 13+12+10+7+1, 14+1, 14+2+1, 14+3+1, 14+4+1, 14+5+1, 14+6+1, 14+7+1, 14+8+1, 14+8+2+1, 14+8+3+1, 14+8+4+1, 14+8+5+1, 14+8+6+1, 14+8+7+1, 14+9+1, 14+9+2+1, 14+9+3+1, 14+9+4+1, 14+9+5+1, 14+9+6+1, 14+9+7+1, 14+10+1, 14+10+2+1, 14+10+3+1, 14+10+4+1, 14+10+5+1, 14+10+6+1, 14+10+7+1, 14+11+1, 14+11+2+1, 14+11+3+1, 14+11+4+1, 14+11+5+1, 14+11+6+1, 14+11+7+1, 14+11+8+1, 14+11+8+2+1, 14+11+8+3+1, 14+11+8+4+1, 14+11+8+5+1, 14+11+8+6+1, 14+11+8+7+1, 14+11+9+1, 14+11+9+2+1, 14+11+9+3+1, 14+11+9+4+1, 14+11+9+5+1,

14+11+9+6+1, 14+11+9+7+1, 14+11+10+1, 14+11+10+2+1, 14+11+10+3+1, 14+11+10+4+1, 14+11+10+5+1,

14+11+10+6+1, 14+11+10+7+1, 14+12+1, 14+12+2+1, 14+12+3+1, 14+12+4+1, 14+12+5+1, 14+12+6+1,

14+12+7+1, 14+12+8+1, 14+12+8+2+1, 14+12+8+3+1, 14+12+8+4+1, 14+12+8+5+1, 14+12+8+6+1, 14+12+8+7+1, 14+12+9+1, 14+12+9+2+1, 14+12+9+3+1, 14+12+9+4+1, 14+12+9+5+1, 14+12+9+6+1, 14+12+9+7+1, 14+12+10+1, 14+12+10+2+1, 14+12+10+3+1, 14+12+10+4+1, 14+12+10+5+1, 14+12+10+6+1, 14+12+10+7+1, 15+1, 15+2+1, 15+3+1, 15+4+1, 15+5+1, 15+6+1, 15+7+1, 15+8+1, 15+8+2+1, 15+8+3+1, 15+8+4+1, 15+8+5+1, 15+8+6+1, 15+8+7+1, 15+9+1, 15+9+2+1, 15+9+3+1, 15+9+4+1, 15+9+5+1, 15+9+6+1, 15+9+7+1, 15+10+1, 15+10+2+1, 15+10+3+1, 15+10+4+1, 15+10+5+1, 15+10+6+1, 15+10+7+1, 15+11+1, 15+11+2+1, 15+11+3+1, 15+11+4+1, 15+11+5+1, 15+11+6+1, 15+11+7+1, 15+11+8+1, 15+11+8+2+1, 15+11+8+3+1, 15+11+8+4+1, 15+11+8+5+1, 15+11+8+6+1, 15+11+8+7+1, 15+11+9+1, 15+11+9+2+1, 15+11+9+3+1, 15+11+9+4+1, 15+11+9+5+1,

15+11+9+6+1, 15+11+9+7+1, 15+11+10+1, 15+11+10+2+1, 15+11+10+3+1, 15+11+10+4+1, 15+11+10+5+1,

15+11+10+6+1, 15+11+10+7+1, 15+12+1, 15+12+2+1, 15+12+3+1, 15+12+4+1, 15+12+5+1, 15+12+6+1,

15+12+7+1, 15+12+8+1, 15+12+8+2+1, 15+12+8+3+1, 15+12+8+4+1, 15+12+8+5+1, 15+12+8+6+1, 15+12+8+7+1, 15+12+9+1, 15+12+9+2+1, 15+12+9+3+1, 15+12+9+4+1, 15+12+9+5+1, 15+12+9+6+1, 15+12+9+7+1, 15+12+10+1, 15+12+10+2+1, 15+12+10+3+1, 15+12+10+4+1, 15+12+10+5+1, 15+12+10+6+1, 15+12+10+7+1, 16+1, 16+2+1, 16+3+1, 16+4+1, 16+5+1, 16+6+1, 16+7+1, 16+8+1, 16+8+2+1, 16+8+3+1, 16+8+4+1, 16+8+5+1, 16+8+6+1, 16+8+7+1, 16+9+1, 16+9+2+1, 16+9+3+1, 16+9+4+1, 16+9+5+1, 16+9+6+1, 16+9+7+1, 16+10+1, 16+10+2+1, 16+10+3+1, 16+10+4+1, 16+10+5+1, 16+10+6+1, 16+10+7+1, 17+1, 17+2+1, 17+3+1, 17+4+1, 17+5+1, 17+6+1, 17+7+1, 17+8+1, 17+8+2+1, 17+8+3+1, 17+8+4+1, 17+8+5+1, 17+8+6+1, 17+8+7+1, 17+9+1, 17+9+2+1, 17+9+3+1, 17+9+4+1, 17+9+5+1, 17+9+6+1, 17+9+7+1, 17+10+1, 17+10+2+1, 17+10+3+1, 17+10+4+1, 17+10+5+1, 17+10+6+1, 17+10+7+1, 17+11+1, 17+11+2+1, 17+11+3+1, 17+11+4+1, 17+11+5+1, 17+11+6+1, 17+11+7+1, 17+11+8+1, 17+11+8+2+1, 17+11+8+3+1, 17+11+8+4+1, 17+11+8+5+1, 17+11+8+6+1, 17+11+8+7+1, 17+11+9+1, 17+11+9+2+1, 17+11+9+3+1, 17+11+9+4+1, 17+11+9+5+1, 17+11+9+6+1, 17+11+9+7+1, 17+11+10+1, 17+11+10+2+1, 17+11+10+3+1, 17+11+10+4+1, 17+11+10+5+1, 17+11+10+6+1, 17+11+10+7+1, 17+12+1, 17+12+2+1, 17+12+3+1, 17+12+4+1, 17+12+5+1, 17+12+6+1, 17+12+7+1, 17+12+8+1, 17+12+8+2+1, 17+12+8+3+1, 17+12+8+4+1, 17+12+8+5+1, 17+12+8+6+1, 17+12+8+7+1, 17+12+9+1, 17+12+9+2+1,

17+12+9+3+1, 17+12+9+4+1, 17+12+9+5+1, 17+12+9+6+1, 17+12+9+7+1, 17+12+10+1, 17+12+10+2+1, 17+12+10+3+1, 17+12+10+4+1, 17+12+10+5+1, 17+12+10+6+1, 17+12+10+7+1, 17+13+1, 17+13+2+1, 17+13+3+1, 17+13+4+1, 17+13+5+1, 17+13+6+1, 17+13+7+1, 17+13+8+1, 17+13+8+2+1, 17+13+8+3+1, 17+13+8+4+1, 17+13+8+5+1, 17+13+8+6+1, 17+13+8+7+1, 17+13+9+1, 17+13+9+2+1, 17+13+9+3+1, 17+13+9+4+1,

17+13+9+5+1, 17+13+9+6+1, 17+13+9+7+1, 17+13+10+1, 17+13+10+2+1, 17+13+10+3+1, 17+13+10+4+1, 17+13+10+5+1, 17+13+10+6+1, 17+13+10+7+1, 17+13+11+1, 17+13+11+2+1, 17+13+11+3+1, 17+13+11+4+1, 17+13+11+5+1, 17+13+11+6+1, 17+13+11+7+1, 17+13+11+8+1, 17+13+11+8+2+1, 17+13+11+8+3+1,

17+13+11+8+4+1, 17+13+11+8+5+1, 17+13+11+8+6+1, 17+13+11+8+7+1, 17+13+11+9+1, 17+13+11+9+2+1, 17+13+11+9+3+1, 17+13+11+9+4+1, 17+13+11+9+5+1, 17+13+11+9+6+1, 17+13+11+9+7+1, 17+13+11+10+1, 17+13+11+10+2+1, 17+13+11+10+3+1, 17+13+11+10+4+1, 17+13+11+10+5+1, 17+13+11+10+6+1,

17+13+11+10+7+1, 17+13+12+1, 17+13+12+2+1, 17+13+12+3+1, 17+13+12+4+1, 17+13+12+5+1, 17+13+12+6+1, 17+13+12+7+1, 17+13+12+8+1, 17+13+12+8+2+1, 17+13+12+8+3+1, 17+13+12+8+4+1, 17+13+12+8+5+1, 17+13+12+8+6+1, 17+13+12+8+7+1, 17+13+12+9+1, 17+13+12+9+2+1, 17+13+12+9+3+1, 17+13+12+9+4+1, 17+13+12+9+5+1, 17+13+12+9+6+1, 17+13+12+9+7+1, 17+13+12+10+1, 17+13+12+10+2+1, 17+13+12+10+3+1, 17+13+12+10+4+1, 17+13+12+10+5+1, 17+13+12+10+6+1, 17+13+12+10+7+1, 17+14+1, 17+14+2+1, 17+14+3+1, 17+14+4+1, 17+14+5+1, 17+14+6+1, 17+14+7+1, 17+14+8+1, 17+14+8+2+1, 17+14+8+3+1, 17+14+8+4+1, 17+14+8+5+1, 17+14+8+6+1, 17+14+8+7+1, 17+14+9+1, 17+14+9+2+1, 17+14+9+3+1, 17+14+9+4+1,

17+14+9+5+1, 17+14+9+6+1, 17+14+9+7+1, 17+14+10+1, 17+14+10+2+1, 17+14+10+3+1, 17+14+10+4+1, 17+14+10+5+1, 17+14+10+6+1, 17+14+10+7+1, 17+14+11+1, 17+14+11+2+1, 17+14+11+3+1, 17+14+11+4+1, 17+14+11+5+1, 17+14+11+6+1, 17+14+11+7+1, 17+14+11+8+1, 17+14+11+8+2+1, 17+14+11+8+3+1,

17+14+11+8+4+1, 17+14+11+8+5+1, 17+14+11+8+6+1, 17+14+11+8+7+1, 17+14+11+9+1, 17+14+11+9+2+1, 17+14+11+9+3+1, 17+14+11+9+4+1, 17+14+11+9+5+1, 17+14+11+9+6+1, 17+14+11+9+7+1, 17+14+11+10+1, 17+14+11+10+2+1, 17+14+11+10+3+1, 17+14+11+10+4+1, 17+14+11+10+5+1, 17+14+11+10+6+1,

17+14+11+10+7+1, 17+14+12+1, 17+14+12+2+1, 17+14+12+3+1, 17+14+12+4+1, 17+14+12+5+1, 17+14+12+6+1, 17+14+12+7+1, 17+14+12+8+1, 17+14+12+8+2+1, 17+14+12+8+3+1, 17+14+12+8+4+1, 17+14+12+8+5+1, 17+14+12+8+6+1, 17+14+12+8+7+1, 17+14+12+9+1, 17+14+12+9+2+1, 17+14+12+9+3+1, 17+14+12+9+4+1, 17+14+12+9+5+1, 17+14+12+9+6+1, 17+14+12+9+7+1, 17+14+12+10+1, 17+14+12+10+2+1, 17+14+12+10+3+1, 17+14+12+10+4+1, 17+14+12+10+5+1, 17+14+12+10+6+1, 17+14+12+10+7+1, 17+15+1, 17+15+2+1, 17+15+3+1, 17+15+4+1, 17+15+5+1, 17+15+6+1, 17+15+7+1, 17+15+8+1, 17+15+8+2+1, 17+15+8+3+1, 17+15+8+4+1, 17+15+8+5+1, 17+15+8+6+1, 17+15+8+7+1, 17+15+9+1, 17+15+9+2+1, 17+15+9+3+1, 17+15+9+4+1,

17+15+9+5+1, 17+15+9+6+1, 17+15+9+7+1, 17+15+10+1, 17+15+10+2+1, 17+15+10+3+1, 17+15+10+4+1, 17+15+10+5+1, 17+15+10+6+1, 17+15+10+7+1, 17+15+11+1, 17+15+11+2+1, 17+15+11+3+1, 17+15+11+4+1, 17+15+11+5+1, 17+15+11+6+1, 17+15+11+7+1, 17+15+11+8+1, 17+15+11+8+2+1, 17+15+11+8+3+1,

17+15+11+8+4+1, 17+15+11+8+5+1, 17+15+11+8+6+1, 17+15+11+8+7+1, 17+15+11+9+1, 17+15+11+9+2+1, 17+15+11+9+3+1, 17+15+11+9+4+1, 17+15+11+9+5+1, 17+15+11+9+6+1, 17+15+11+9+7+1, 17+15+11+10+1, 17+15+11+10+2+1, 17+15+11+10+3+1, 17+15+11+10+4+1, 17+15+11+10+5+1, 17+15+11+10+6+1,

17+15+11+10+7+1, 17+15+12+1, 17+15+12+2+1, 17+15+12+3+1, 17+15+12+4+1, 17+15+12+5+1, 17+15+12+6+1, 17+15+12+7+1, 17+15+12+8+1, 17+15+12+8+2+1, 17+15+12+8+3+1, 17+15+12+8+4+1, 17+15+12+8+5+1, 17+15+12+8+6+1, 17+15+12+8+7+1, 17+15+12+9+1, 17+15+12+9+2+1, 17+15+12+9+3+1, 17+15+12+9+4+1, 17+15+12+9+5+1, 17+15+12+9+6+1, 17+15+12+9+7+1, 17+15+12+10+1, 17+15+12+10+2+1, 17+15+12+10+3+1, 17+15+12+10+4+1, 17+15+12+10+5+1, 17+15+12+10+6+1, 17+15+12+10+7+1, 17+16+1, 17+16+2+1, 17+16+3+1, 17+16+4+1, 17+16+5+1, 17+16+6+1, 17+16+7+1, 17+16+8+1, 17+16+8+2+1, 17+16+8+3+1, 17+16+8+4+1, 17+16+8+5+1, 17+16+8+6+1, 17+16+8+7+1, 17+16+9+1, 17+16+9+2+1, 17+16+9+3+1, 17+16+9+4+1,

17+16+9+5+1, 17+16+9+6+1, 17+16+9+7+1, 17+16+10+1, 17+16+10+2+1, 17+16+10+3+1, 17+16+10+4+1, 17+16+10+5+1, 17+16+10+6+1, 17+16+10+7+1.

In the list above the numbers refer to the embodiments according to their numbering provided hereinabove whereas "+” indicates the dependency from another embodiment. The different individualized embodiments are separated by commas. In other words, "17+16+7+1” for example refers to embodiment 17) depending on embodiment 16), depending on embodiment 7), depending on embodiment 1), i.e. embodiment "17+16+7+1” corresponds to the compounds of formula (I) according to embodiment 1) further limited by all the features of the embodiments 7), 16), and 17).

19) Another embodiment relates to compounds of Formula (I) according to embodiment 1), which are selected from the following compounds:

(2R,3R,4S,5R,6R)-N-benzyl-3,5-dihydroxy-N-((1S,2S)-2-hydr oxycyclohexyl)-6-(hydroxymethyl)-4-(4-(3,4,5- trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2 -carboxamide; (2R,3R,4S,5R,6R)-N-(3-chlorobenzyl)-3,5-dihydroxy-N-((1S,2S) -2-hydroxycyclohexyl)-6-(hydroxymethyl)-4-(4-(3,4,5- trifIuorophenyI )- 1H- 1 , 2, 3-tri azol-1-yI )tetrahydro-2H-pyran-2-carboxam ide;

(2R,3R,4S,5R,6R)-N-(3-ethynylbenzyl)-3,5-dihydroxy-N-((1S ,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-4-(4-

(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro- 2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-3,5-dihydroxy-N-((1S,2S)-2-hydroxycycloh exyl)-6-(hydroxymethyl)-N-phenethyl-4-(4-(3,4,5- trifIuorophenyI )- 1H- 1 , 2, 3-tri azol-1-yI )tetrahy d ro-2 H-py ran-2-carboxam ide;

(2R,3R,4S,5R,6R)-N-(4-chlorobenzyl)-3,5-dihydroxy-N-((1S, 2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-4-(4-(3,4,5- trif I uorophenyI )- 1H- 1 , 2, 3-tri azol -1-yI )tetrahy d ro-2 H-py ran-2-carboxam ide;

(2R,3R,4S,5R,6R)-N-(2-chlorobenzyl)-3,5-dihydroxy-N-((1S, 2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-4-(4-(3,4,5- trifIuorophenyI )- 1H- 1 , 2, 3-tri azol -1-yI )tetrahy d ro-2 H-py ran-2-carboxam ide;

(2R,3R,4S,5R,6R)-3,5-dihydroxy-N-((1S,2S)-2-hydroxycycloh exyl)-6-(hydroxymethyl)-N-(2-(trifluoromethyl)benzyl)-4- (4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro- 2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-((3-chloropyridin-4-yl)methyl)-3,5-dihydr oxy-N-((1S,2S)-2-hydroxycyclohexyl)-6- (hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazo l-1-yl)tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-3,5-dihydroxy-N-((1S,2S)-2-hydroxycyclohexy l)-6-(hydroxymethyl)-N-((2-(trifluoromethyl)pyridin-3- yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-y l)tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-3,5-dihydroxy-N-((1S,2S)-2-hydroxycyclohexy l)-6-(hydroxymethyl)-N-((4-(trifluoromethyl)pyridin-3- yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-y l)tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl)-6 -(hydroxymethyl)-3-methoxy-N-(2- (trifluoromethyl)benzyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2 ,3-triazol-1-yl)tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(2-chlorobenzyl)-5-hydroxy-N-((1S,2S)-2-h ydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy-4- (4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yI)tetrahydro- 2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-3,5-dihydroxy-N-((1S,2S)-2-hydroxycycloh exyl)-6-(hydroxymethyl)-N-((3-(trifluoromethyl)pyridin-2- yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-y l)tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-3,5-dihydroxy-N-((1 S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-N-((2-methyl-1H -imidazol-4- yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-y l)tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-((2-amino-4-chlorothiazol-5-yl)methyl)-3, 5-dihydroxy-N-((1S,2S)-2-hydroxycyclohexyl)-6- (hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazo l-1-yl)tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-3,5-dihydroxy-N-((1S,2S)-2-hydroxycyclohexy l)-6-(hydroxymethyl)-N-(isoxazol-4-ylmethyl)-4-(4- (3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yI)tetrahydro-2H- pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-((5-chlorofuran-2-yl)methyl)-3,5-dihyd roxy-N-((1 S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)- 4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydr o-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-3,5-dihydroxy-N-((1S,2S)-2-hydroxycycloh exyl)-6-(hydroxymethyl)-N-(isothiazol-4-ylmethyl)-4-(4- (3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yI)tetrahydro-2H- pyran-2-carboxamide; (2R,3R,4S,5R,6R)-3,5-dihydroxy-N-((1 S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-N-((1-methyl-1H -imidazol-4- yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-y l)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-((2-bromothiazol-4-yl)methyl)-3,5-dihy droxy-N-((1S,2S)-2-hydroxycyclohexyl)-6-

(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-tri azol-1-yl)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-3,5-dihydroxy-N-((1S,2S)-2-hydroxycycloh exyl)-6-(hydroxymethyl)-N-((2-morpholinothiazol-5- yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-y l)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-((5-chlorothiophen-2-yl)methyl)-3,5-di hydroxy-N-((1S,2S)-2-hydroxycyclohexyl)-6-

(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-tri azol-1-yl)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-((5-chlorothiazol-2-yl)methyl)-3,5-dih ydroxy-N-((1S,2S)-2-hydroxycyclohexyl)-6-

(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-tri azol-1-yl)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-3,5-dihydroxy-N-((1 S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-N-((1-methyl-1H -pyrazol-3- yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-y l)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl )-6-(hydroxymethyl)-3-methoxy-N-((3-

(trifluoromethyl)pyridin-2-yl)methyl)-4-(4-(3,4,5-trifluo rophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2- carboxamide;

(2R,3R,4S,5R,6R)-5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl )-6-(hydroxymethyl)-3-methoxy-N-((2- (trifluoromethyl)pyridin-3-yl)methyl)-4-(4-(3,4,5-trifluorop henyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2- carboxamide;

(2R,3R,4S,5R,6R)-3,5-dihydroxy-N-((1S,2S)-2-hydroxycycloh exyl)-6-(hydroxymethyl)-N-((4-(trifluoromethyl)pyrimidin- 5-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1 -yl)tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-((4,6-dimethoxypyrimidin-5-yl)methyl)-3,5 -dihydroxy-N-((1S,2S)-2-hydroxycyclohexyl)-6- (hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazo l-1-yl)tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-3,5-dihydroxy-N-((1S,2S)-2-hydroxycyclohexy l)-6-(hydroxymethyl)-N-((4-methylpyrimidin-5- yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-y l)tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl)-6 -(hydroxymethyl)-3-methoxy-N-((5-methyl-1H- imidazol-4-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3- triazol-1-yl)tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-((4-chloroisothiazol-5-yl)methyl)-5-hydro xy-N-((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)- 3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl )tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl)-6 -(hydroxymethyl)-3-methoxy-N-((1-methyl-1H- pyrazol-5-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-t riazol-1-yl)tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl)-6 -(hydroxymethyl)-3-methoxy-N-((3-methylthiophen- 2-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1 -yl)tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl)-6 -(hydroxymethyl)-3-methoxy-N-((1-methyl-1H-pyrrol- 2-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1 -yl)tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-((3-chlorothiophen-2-yl)methyl)-5-hydroxy -N-((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-

3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1 -yl)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl )-6-(hydroxymethyl)-3-methoxy-N-((4-methylthiazol-5- yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-y l)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl )-6-(hydroxymethyl)-3-methoxy-N-((1-methyl-1H- imidazol-2-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3- triazol-1-yl)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl )-6-(hydroxymethyl)-3-methoxy-N-((2-methylthiophen-

3-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazo l-1-yl)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl )-6-(hydroxymethyl)-3-methoxy-N-(2-methoxybenzyl)-4-

(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yI)tetrahyd ro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(2,6-dimethoxybenzyl)-5-hydroxy-N-((1S ,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3- methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)t etrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-3,5-dihydroxy-N-((1 S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-N-((1-methyl-1H -imidazol-2- yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-y l)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-3,5-dihydroxy-N-((1 S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-N-((1-methyl-1H -imidazol-2- yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-y l)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-5-hydroxy-2-(((1S,2S)-2-hydroxycyclohexy l)((1-methyl-1H-pyrazol-5-yl)methyl)carbamoyl)-6-

(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-tri azol-1-yl)tetrahydro-2H-pyran-3-yl acetate;

(2R,3R,4S,5R,6R)-N-((1-ethyl-1H-pyrazol-5-yl)methyl)-5-hy droxy-N-((1S,2S)-2-hydroxycyclohexyl)-6-

(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-tiifluorophenyl)-1H -1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-5-hydroxy-N-((1 S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-N-((1 -isopropyl-1H-pyrazol-5- yl)methyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-t riazol-1-yl)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-((1-(cyclopropylmethyl)-1H-pyrazol-5-y l)methyl)-5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl)-6-

(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H -1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-((1,3-dimethyl-1H-pyrazol-5-yl)methyl) -5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl)-6-

(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H -1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl )-6-(hydroxymethyl)-3-methoxy-N-((1-methyl-1H-indol-

2-yl)methyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazo l-1-yl)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(3,5-difluorophenyl)-1H-1,2,3-triaz ol-1-yl)-5-hydroxy-2-(((1S,2S)-2-hydroxycyclohexyl)((1- methyl-1H-pyrazol-5-yl)methyl)carbamoyl)-6-(hydroxymethyl)te trahydro-2H-pyran-3-yl acetate;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-3,5-difluorophenyl)-1H-1, 2,3-triazol-1-yl)-5-hydroxy-2-(((1S,2S)-2- hydroxycyclohexyl)((1-methyl-1H-pyrazol-5-yl)methyl)carbamoy l)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl acetate;

(2R,3R,4S,5R,6R)-4-(4-(3,5-difluoro-4-methylphenyl)-1H-1, 2,3-triazol-1-yl)-5-hydroxy-2-(((1S,2S)-2- hydroxycyclohexyl)((1-methyl-1H-pyrazol-5-yl)methyl)carbamoy l)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl acetate; (2R,3R,4S,5R,6R)-4-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl )-5-hydroxy-2-(((1S,2S)-2-hydroxycyclohexyl)((1-methyl-

1H-pyrazol-5-yl)methyl)carbamoyl)-6-(hydroxymethyl)tetrah ydro-2H-pyran-3-yl acetate;

(2R,3R,4S,5R,6R)-N-(3-chlorobenzyl)-5-hydroxy-N-((1S,2S)- 2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy-4-

(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahyd ro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(3,5-difluoro-4-methylphenyl)-1H-1, 2,3-triazol-1-yl)-5-hydroxy-2-(((1S,2S)-2- hydroxycyclohexyl)(2-(trifluoromethyl)benzyl)carbamoyl)-6-(h ydroxymethyl)tetrahydro-2H-pyran-3-yl acetate;

(2R,3R,4S,5R,6R)-5-hydroxy-2-(((1S,2S)-2-hydroxycyclohexy l)(2-(trifluoromethyl)benzyl)carbamoyl)-6-

(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-tri azol-1-yl)tetrahydro-2H-pyran-3-yl acetate;

(2R,3R,4S,5R,6R)-N-(3,4-difluorophenyl)-5-hydroxy-N-((1S, 2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy-

4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrah ydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-chlorophenyl)-5-hydroxy-N-((1S,2S)- 2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy-4- (4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yI)tetrahydro- 2H-pyran-2-carboxamide; and (2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-5-hydroxy-N-((1S,2S) -2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy- 4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydr o-2H-pyran-2-carboxamide.

20) In addition to the compounds listed in embodiment 19), further compounds according to embodiment 1) are selected from the following compounds:

(2R,3R,4S,5R,6R)-4-(4-(3-fluorophenyl)-1H-1,2,3-triazo yl)-5-hydroxy-2-(((1 S,2S)-2-hydroxycyclohexyl)(2-

(trifluoromethyl)benzyl)carbamoyl)-6-(hydroxymethyl)tetra hydro-2H-pyran-3-yl acetate;

(2R,3R,4S,5R,6R)-4-(4-(3,5-difluorophenyl)-1H-1,2,3-triaz ol-1-yl)-5-hydroxy-2-(((1S,2S)-2-hydroxycyclohexyl)(2-

(trifluoromethyl)benzyl)carbamoyl)-6-(hydroxymethyl)tetra hydro-2H-pyran-3-yl acetate;

(2R,3R,4S,5R,6R)-N-((6-fluoro-3-methoxyquinoxalin-5-yl)me thyl)-5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl)-6-

(hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H -1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-((3-chloroquinolin-2-yl)methyl)-5-hydr oxy-N-((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3- methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)t etrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(3-chloro-4,5-difluorophenyl)-1H-1, 2,3-triazol-1-yl)-3,5-dihydroxy-N-((1S,2S)-2- hydroxycyclohexyl)-6-(hydroxymethyl)-N-(2-(trifluoromethyl)b enzyl)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-3,5-difluorophenyl)-1H-1, 2,3-triazol-1-yl)-3,5-dihydroxy-N-((1S,2S)-2- hydroxycyclohexyl)-6-(hydroxymethyl)-N-(2-(trifluoromethyl)b enzyl)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-3,5-difluorophenyl)-1H-1, 2,3-triazol-1-yl)-5-hydroxy-2-(((1S,2S)-2- hydroxycyclohexyl)(2-(trifluoromethyl)benzyl)carbamoyl)-6-(h ydroxymethyl)tetrahydro-2H-pyran-3-yl acetate;

(2R,3R,4S,5R,6R)-4-(4-(4-bromo-3,5-difluorophenyl)-1H-1,2 ,3-triazol-1-yl)-3,5-dihydroxy-N-((1S,2S)-2- hydroxycyclohexyl)-6-(hydroxymethyl)-N-(2-(trifluoromethyl)b enzyl)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(4-bromo-3-fluorophenyl)-1H-1,2,3-t riazo yl)-3,5-dihydroxy-N-((1S,2S)-2- hydroxycyclohexyl)-6-(hydroxymethyl)-N-(2-(trifluoromethyl)b enzyl)tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-4-(4-(4-chlorothiazol-2-yl)-1H-1,2,3-triazo l-1-yl)-3,5-dihydroxy-N-((1S,2S)-2-hydroxycyclohexyl)-6-

(hydroxymethyl)-N-(2-(trifluoromethyl)benzyl)tetrahydro-2 H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-4-(4-(3-fluorophe nyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-((1S,2S)-2- hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydro-2H- pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(3-fluorophenyl)-1H-1,2,3-triazol-l -yl)-5-hydroxy-N-((1 S,2S)-2-hydroxycyclohexyl)-6-

(hydroxymethyl)-3-methoxy-N-(3-methoxyphenyl)tetrahydro-2 H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-chloro-5-cyanophenyl)-4-(4-(3-fluor ophenyl)-1H-1,2,3-triazol-l -yl)-5-hydroxy-N-((1S,2S)-2- hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydro-2H- pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-chloro-5-cyanophenyl)-4-(4-(3-fluor o-2-methylphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-chloro-5-cyanophenyl)-4-(4-(5-fluor o-2-methoxyphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-bromo-5-cyanophenyl)-4-(4-(3-fluoro phenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-((1S,2S)-2- hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydro-2H- pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-4-(4-(3,5-difluor ophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-((1S,2S)-2- hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydro-2H- pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(3,5-difluorophenyl)-1H-1,2,3-triaz ol-1-yl)-5-hydroxy-N-((1 S,2S)-2-hydroxycyclohexyl)-6-

(hydroxymethyl)-3-methoxy-N-(3-methoxyphenyl)tetrahydro-2 H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-chloro-5-cyanophenyl)-4-(4-(3,5-dif luorophenyl)-1H-1,2,3-triazol-l -yl)-5-hydroxy-N-((1 S,2S)- 2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydro-2 H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3-cyano-5-methylphenyl)-4-(4-(3,5-difluo rophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-((1 S,2S)- 2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydro-2 H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3-cyano-5-methoxyphenyl)-4-(4-(3,5-diflu orophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N- ((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytet rahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3-chloro-5-methylphenyl)-4-(4-(3,5-diflu orophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-((1 S,2S)- 2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydro-2 H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3-bromophenyl)-4-(4-(3,5-difluorophenyl) -1H-1,2,3-triazol-1-yl)-5-hydroxy-N-((1 S,2S)-2- hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydro-2H- pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3-chlorophenyl)-4-(4-(3,5-difluorophenyl )-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-((1S,2S)-2- hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydro-2H- pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3-cyanophenyl)-4-(4-(3,5-difluorophenyl) -1H-1,2,3-triazol-l -yl)-5-hydroxy-N-((1 S,2S)-2- hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydro-2H- pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-5-hydroxy-N-((1S, 2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-(methoxy- d3)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-l -yl)tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3-chloro-5-cyanophenyl)-5-hydroxy-N-((1S ,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3- methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)t etrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(5-chloro-2-methylphenyl)-5-hydroxy-N-((1 S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3- methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)t etrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3-chloro-4-fluorophenyl)-5-hydroxy-N-((1 S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3- methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)t etrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3-chloro-4-(trifluoromethyl)phenyl)-5-hy droxy-N-((1S,2S)-2-hydroxycyclohexyl)-6- (hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1, 2,3-triazol-1-yl)tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3-bromo-4-fluorophenyl)-5-hydroxy-N-((1S ,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3- methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)t etrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(benzo[d]thiazol-6-yl)-5-hydroxy-N-((1S,2 S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3- methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)t etrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl)-6 -(hydroxymethyl)-3-methoxy-N-(2- methylbenzo[d]thiazol-6-yl)-4-(4-(3,4,5-trifluorophenyl)-1H- 1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3-chloro-5-(trifluoromethyl)phenyl)-5-hy droxy-N-((1S,2S)-2-hydroxycyclohexyl)-6- (hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1, 2,3-triazol-1-yl)tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3-bromo-5-chlorophenyl)-5-hydroxy-N-((1S ,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3- methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)t etrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3,5-dibromophenyl)-5-hydroxy-N-((1S,2S)- 2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy- 4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydr o-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3,4-dichlorophenyl)-5-hydroxy-N-((1S, 2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy- 4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydr o-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3-bromo-4-chlorophenyl)-5-hydroxy-N-((1S ,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3- methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)t etrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl)-6 -(hydroxymethyl)-3-methoxy-N-phenyl-4-(4-(3,4,5- trifluorophenyl)-1H-1,2,3-triazol-1-yI)tetrahydro-2H-pyran-2 -carboxamide;

(2R,3R,4S,5R,6R)-5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl )-6-(hydroxymethyl)-3-methoxy-N-(3-methoxyphenyl)-4- (4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yI)tetrahydro- 2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(benzo[b]thiophen-6-yl)-5-hydroxy-N-((1S, 2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3- methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)t etrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3-bromophenyl)-5-hydroxy-N-((1S,2S)-2-hy droxycyclohexyl)-6-(hydroxymethyl)-3-methoxy-4- (4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yI)tetrahydro- 2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-chloro-5-methoxyphenyl)-5-hydroxy-N -((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3- methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)t etrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(5-chloro-2-fluorophenyl)-5-hydroxy-N-((1 S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3- methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)t etrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(2,5-dimethylbenzo[d]thiazol-6-yl)-5-hydr oxy-N-((1S,2S)-2-hydroxycyclohexyl)-6- (hydroxymethyl)-3-methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1, 2,3-triazol-1-yl)tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(2-chlorobenzo[d]thiazol-6-yl)-5-hydroxy- N-((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3- methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)t etrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3-cyano-5-methoxyphenyl)-5-hydroxy-N-((1 S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3- methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)t etrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(5-bromo-2-methylphenyl)-5-hydroxy-N-((1S ,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3- methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)t etrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(4-chlorophenyl)-5-hydroxy-N-((1S,2S)-2-h ydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy-4- (4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yI)tetrahydro- 2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-bromo-5-cyanophenyl)-5-hydroxy-N-(( 1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3- methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)t etrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3-cyano-5-fluorophenyl)-5-hydroxy-N-((1S ,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3- methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)t etrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3-fluorophenyl)-5-hydroxy-N-((1S,2S)-2-h ydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy-4-(4- (3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yI)tetrahydro-2H- pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-cyanophenyl)-5-hydroxy-N-((1S,2S)-2 -hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy-4- (4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yI)tetrahydro- 2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl)-6 -(hydroxymethyl)-3-methoxy-N-(3- (trifluoromethyl)phenyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2 ,3-triazol-1-yl)tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3,5-difluorophenyl)-5-hydroxy-N-((1S,2S) -2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy- 4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydr o-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-fluoro-5-methoxyphenyl)-5-hydroxy-N -((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3- methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)t etrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3-fluoro-5-methylphenyl)-5-hydroxy-N-((1 S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3- methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)t etrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3-bromo-5-fluorophenyl)-5-hydroxy-N-((1S ,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3- methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)t etrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3-chloro-5-fluorophenyl)-5-hydroxy-N-((1 S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3- methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)t etrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl)-6 -(hydroxymethyl)-3-methoxy-N-(m-tolyl)-4-(4-(3,4,5- trifluorophenyl)-1H-1,2,3-triazol-1-yI)tetrahydro-2H-pyran-2 -carboxamide; (2R,3R,4S,5R,6R)-5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl)-6 -(hydroxymethyl)-3-methoxy-N-(2-methyl-1H- benzo[d]imidazol-6-yl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3 -triazol-1-yl)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(3-chloro-4,5-difluorophenyl)-1H-1, 2,3-triazol-1-yl)-N-(3,5-dichlorophenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(3-chloro-4,5-difluorophenyl)-1H-1, 2,3-triazol-1-yl)-N-(3,4-difluorophenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(benzo[d]thiazol-6-yl)-4-(4-(3-chloro- 4,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(3-chloro-4,5-difluorophenyl)-1H-1, 2,3-triazol-1-yl)-N-(3-chloro-5-cyanophenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-chloro-5-cyanophenyl)-4-(4-(3-chlor o-5-fluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(3-chloro-5-fluorophenyl)-1H-1,2,3- triazol-1-yl)-N-(3,4-difluorophenyl)-5-hydroxy-N-((1S,2S)-

2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydr o-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(3-chloro-5-fluorophenyl)-1H-1,2,3- triazol-1-yl)-N-(3-cyano-5-fluorophenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-bromo-5-fluorophenyl)-4-(4-(3-chlor o-5-fluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-bromo-5-cyanophenyl)-4-(4-(3-chloro -5-fluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-bromophenyl)-4-(4-(3-chloro-5-fluor ophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-((1S,2S)-2- hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydro-2H- pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(3-chloro-5-fluorophenyl)-1H-1,2,3- triazol-1-yl)-N-(3,5-dichlorophenyl)-5-hydroxy-N-((1S,2S)-

2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydr o-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(3-chloro-5-fluorophenyl)-1H-1,2,3- triazol-1-yl)-N-(3-cyano-5-methylphenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(3-chloro-5-fluorophenyl)-1H-1,2,3- triazol-1-yl)-N-(3-cyano-5-methoxyphenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(3-chloro-5-fluorophenyl)-1H-1,2,3- triazol-1-yI)-N-(3-cyanophenyl)-5-hydroxy-N-((1 S,2S)-2- hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydro-2H- pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(3-chloro-5-fluorophenyl)-1H-1,2,3- triazol-1-yI)-N-(3-chlorophenyl)-5-hydroxy-N-((1 S,2S)-2- hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydro-2H- pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(3-bromo-5-fluorophenyl)-1H-1,2,3-t riazol-1-yl)-N-(3,5-dichlorophenyl)-5-hydroxy-N-((1S,2S)-

2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydr o-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-4-(4-(3-bromo-5-fluorophenyl)-1H-1,2,3-tria zol-1-yl)-N-(3-chloro-5-cyanophenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(3-bromo-5-fluorophenyl)-1H-1,2,3-t riazol-1-yl)-N-(3-cyano-5-methylphenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(3-bromo-5-fluorophenyl)-1H-1,2,3-t riazol-1-yl)-N-(3-chloro-5-fluorophenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(3-bromo-5-fluorophenyl)-1H-1,2,3-t riazol-1-yI)-N-(3-cyanophenyl)-5-hydroxy-N-((1 S,2S)-2- hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydro-2H- pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(3-bromo-5-fluorophenyl)-1H-1,2,3-t riazo yl)-N-(3-chlorophenyl)-5-hydroxy-N-((1 S,2S)-2- hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydro-2H- pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(3-bromo-5-fluorophenyl)-1H-1,2,3-t riazol-1-yl)-N-(3-cyano-5-methoxyphenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(4-bromo-3,5-difluorophenyl)-1H-1,2 ,3-triazol-1-yl)-N-(3,5-dichlorophenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(4-bromo-3,5-difluorophenyl)-1H-1,2 ,3-triazol-1-yl)-N-(3,4-difluorophenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(benzo[d]thiazol-5-yl)-4-(4-(4-bromo-3 ,5-difluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(4-bromo-3,5-difluorophenyl)-1H-1,2 ,3-triazol-1-yl)-N-(3-chloro-5-cyanophenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(4-bromo-3,5-difluorophenyl)-1H-1,2 ,3-triazol-1-yl)-N-(3-cyano-5-fluorophenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-3,5-difluorophenyl)-1H-1, 2,3-triazol-1-yl)-N-(3,5-dichlorophenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-3,5-difluorophenyl)-1H-1, 2,3-triazol-1-yl)-N-(3-chloro-5-cyanophenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-4-(4-(3,5-difluor o-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-chloro-5-cyanophenyl)-4-(4-(3,5-dif luoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-bromo-5-fluorophenyl)-4-(4-(3,5-dif luoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-cyano-5-fluorophenyl)-4-(4-(3,5-dif luoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-4-(4-(3,4-difluoroph enyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-((1S,2S)-2- hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydro-2H- pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(4-bromo-3-fluorophenyl)-1H-1,2,3-t riazol-1-yl)-N-(3,5-dichlorophenyl)-5-hydroxy-N-((1S,2S)-

2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydr o-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(4-bromo-3-fluorophenyl)-1H-1,2,3-t riazol-1-yl)-N-(3,4-difluorophenyl)-5-hydroxy-N-((1S,2S)-

2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydr o-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(4-bromo-3-fluorophenyl)-1H-1,2,3-t riazol-1-yl)-N-(3-chloro-5-cyanophenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(3,4-dichloro-5-fluorophenyl)-1H-1, 2,3-triazol-1-yl)-N-(3,5-dichlorophenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(3,4-dichloro-5-fluorophenyl)-1H-1, 2,3-triazol-1-yl)-N-(3,4-difluorophenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(benzo[d]thiazol-6-yl)-4-(4-(3,4-dichl oro-5-fluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-chloro-5-cyanophenyl)-4-(4-(3,4-dic hloro-5-fluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-chloro-5-cyanophenyl)-4-(4-(3-fluor o-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-chloro-5-cyanophenyl)-4-(4-(2,3-dif luoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

2-(((2R,3R,4S,5R,6R)-2-((3-chloro-5-cyanophenyl)((1S,2S)- 2-hydroxycyclohexyl)carbamoyl)-4-(4-(2,3-difluoro-4- methylphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-6-(hydroxymet hyl)tetrahydro-2H-pyran-3-yl)oxy)acetic acid;

(2R,3R,4S,5R,6R)-N-(3-chloro-5-cyanophenyl)-4-(4-(2,3-dif luoro-4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-(2-morp holino-2-oxoethoxy)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-chloro-5-cyanophenyl)-4-(4-(4,5-dif luoro-2-methoxyphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-

N-((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-metho xytetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(4-bromo-2,3-difluorophenyl)-1H-1,2 ,3-triazol-1-yl)-N-(3-chloro-5-cyanophenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(4-bromo-2,3-difluorophenyl)-1H-1,2 ,3-triazol-1-yl)-N-(3-cyano-5-fluorophenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(4-bromo-2,3-difluorophenyl)-1H-1,2 ,3-triazol-1-yl)-N-(3,5-dichlorophenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,3-difluorophenyl)-1H-1, 2,3-triazol-1-yl)-N-(3-chloro-5-cyanophenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-4-(4-(4-chloro-3-fluorophenyl)-1H-1,2,3-tri azol-1-yl)-N-(3,5-dichlorophenyl)-5-hydroxy-N-((1S,2S)-

2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydr o-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-4-(4-(3-fluoro-4- (trifluoromethyl)phenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-chloro-5-cyanophenyl)-4-(4-(4-cyano -3-fluorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-2,5-difluorophenyl)-1H-1, 2,3-triazol-1-yl)-N-(3-chloro-5-cyanophenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-4-(4-(3,4-difluor o-5-methoxyphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-3-methoxyphenyl)-1H-1,2,3 -triazol-1-yl)-N-(3-chloro-5-cyanophenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(4-chloro-3-(trifluoromethoxy)pheny l)-1H-1,2,3-triazol-1-yl)-N-(3-chloro-5-cyanophenyl)-5- hydroxy-N-((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3- methoxytetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-chloro-5-cyanophenyl)-4-(4-(3,4-dic hlorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-((1S,2S)-

2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydr o-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-cyano-5-fluorophenyl)-4-(4-(3,4-dic hlorophenyl)-1H-1,2,3-triazol-1-yI)-5-hydroxy-N-((1 S,2S)-

2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydr o-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-cyano-5-methoxyphenyl)-4-(4-(3,4-di chlorophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-4-(4-(3,4-dichlor ophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-((1S,2S)-2- hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydro-2H- pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-chloro-5-cyanophenyl)-4-(4-(3-fluor o-5-methylphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-5-hydroxy-N-((1S, 2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy-

4-(4-(2-methylbenzo[d]thiazol-6-yl)-1H-1,2,3-triazol-1-yl )tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-4-(4-(4-fluoronap hthalen-1-yl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-((1S,2S)-

2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydr o-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(4-chlorothiazol-2-yl)-1H-1,2,3-tri azo yl)-N-(2,3-difluorophenyl)-5-hydroxy-N-((1 S,2S)-2- hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydro-2H- pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl )-6-(hydroxymethyl)-3-methoxy-N-(pyridin-2-yl)-4-(4-

(3,4,5-trifluorophenyl)-1H-1,2,3-triazo yl)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl )-6-(hydroxymethyl)-3-methoxy-N-(naphthalen-2-yl)-4- (4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro- 2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl)-6 -(hydroxymethyl)-3-methoxy-N-(naphthalen-1-yl)-4- (4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazo yl)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(1,5-dimethyl-1H-pyrazol-3-yl)-5-hydro xy-N-((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3- methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)t etrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-bromo-5-cyanophenyl)-4-(4-(3-fluoro -4-methylphenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-chloro-5-cyanophenyl)-4-(4-(4-chlor ophenyl)-1H-1,2,3-triazo yl)-5-hydroxy-N-((1S,2S)-2- hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydro-2H- pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(4-bromophenyl)-1H-1,2,3-triazol-1- yI)-N-(3-chloro-5-cyanophenyl)-5-hydroxy-N-((1 S,2S)-2- hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytetrahydro-2H- pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(4-cyano-3-fluorophenyl)-1H-1,2,3-t riazol-1-yl)-N-(3-cyano-5-methoxyphenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-4-(4-(4-cyano-3-fluorophenyl)-1H-1,2,3-t riazol-1-yl)-N-(3-cyano-5-methylphenyl)-5-hydroxy-N-

((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxy tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3-chlorophenyl)-5-hydroxy-N-((1S,2S)- 2-hydroxycycloheptyl)-6-(hydroxymethyl)-3-methoxy-4-

(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazo yl)tetrahydro-2H-pyran-2-carboxamide;

(2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-5-hydroxy-N-((1S, 2S)-2-hydroxycycloheptyl)-6-(hydroxymethyl)-3-methoxy- 4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yI)tetrahydr o-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-5-hydroxy-N-((1S,2S) -2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-(2- morpholino-2-oxoethoxy)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2, 3-triazol-1-yl)tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-5-hydroxy-N-((1S,2S) -2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-(2-((S)-3- hydroxypyrrolidin-1-yl)-2-oxoethoxy)-4-(4-(3,4,5-trifluoroph enyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2- carboxamide;

(2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-5-hydroxy-N-((1S, 2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-(2-((R)-3- hydroxypyrrolidin-1-yl)-2-oxoethoxy)-4-(4-(3,4,5-trifluoroph enyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2- carboxamide;

(2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-5-hydroxy-N-((1S, 2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-(2-(4- hydroxypiperidin-1-yI)-2-oxoethoxy)-4-(4-(3,4,5-trifluorophe nyl)-1H-1,2,3-triazol-1-yI)tetrahydro-2H-pyran-2- carboxamide;

(2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-5-hydroxy-3-(2-(3 -hydroxyazetidin-1-yl)-2-oxoethoxy)-N-((1S,2S)-2- hydroxycyclohexyl)-6-(hydroxymethyl)-4-(4-(3,4,5-trifluoroph enyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2- carboxamide;

2-(((2R,3R,4S,5R,6R)-2-((3,5-dichlorophenyl)((1S,2S)-2-hy droxycyclohexyl)carbamoyl)-5-hydroxy-6-(hydroxymethyl)- 4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yI)tetrahydr o-2H-pyran-3-yl)oxy)acetic acid; (2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-5-hydroxy-N-((1S,2S) -2-hydroxycyclohexyl)-3-(2-hydroxyethoxy)-6- (hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazo l-1-yl)tetrahydro-2H-pyran-2-carboxamide; (2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-4-(4-(3,5-difluoro-4 -morpholinophenyl)-1H-1,2,3-triazol-1-yl)-5-hydroxy-N- ((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-3-methoxytet rahydro-2H-pyran-2-carboxamide; and (2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-4-(4-(3,5-difluoro-4 -((3-hydroxypropyl)amino)phenyl)-1H-1,2,3-triazol-1-yl)- 5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)- 3-methoxytetrahydro-2H-pyran-2-carboxamide.

The compounds of Formula (I) according to embodiments 1) to 20) and their pharmaceutically acceptable salts can be used as medicaments, e.g. in the form of pharmaceutical compositions for enteral (such especially oral e.g. in form of a tablet or a capsule) or parenteral administration (including topical application or inhalation).

The production of the pharmaceutical compositions can be effected in a manner which will be familiar to any person skilled in the art (see for example Remington, The Science and Practice of Pharmacy, 21st Edition (2005), Part 5, "Pharmaceutical Manufacturing” [published by Lippincott Williams & Wilkins]) by bringing the described compounds of Formula (I) or their pharmaceutically acceptable salts, optionally in combination with other therapeutically valuable substances, into a galenical administration form together with suitable, non-toxic, inert, therapeutically compatible solid or liquid carrier materials and, if desired, usual pharmaceutical adjuvants.

The present invention also relates to a method for the prevention / prophylaxis or treatment of a disease or disorder mentioned herein comprising administering to a subject a pharmaceutically active amount of a compound of Formula (I) according to embodiments 1) to 20). In a sub- embodiment of the invention, the administered amount is comprised between 1 mg and 1000 mg per day.

For avoidance of any doubt, if compounds are described as useful for the prevention / prophylaxis or treatment of certain diseases, such compounds are likewise suitable for use in the preparation of a medicament for the prevention / prophylaxis or treatment of said diseases. Likewise, such compounds are also suitable in a method for the prevention / prophylaxis or treatment of such diseases, comprising administering to a subject (mammal, especially human) in need thereof, an effective amount of such compound.

21) Another embodiment relates to the compounds of formula (I) as defined in any one of embodiments 1) to 20) which are useful for the prevention / prophylaxis or treatment of diseases and disorders that are related to galectin-3 binding to natural ligands.

Such diseases and disorders that are related to Gal-3 binding to natural ligands are especially diseases and disorders in which inhibition of the physiological activity of Gal-3 is useful, such as diseases in which a Gal-3 receptor participates, is involved in the etiology or pathology of the disease, or is otherwise associated with at least one symptom of the disease. Diseases or disorders that are related to galectin-3 binding to natural ligands may in particular be defined as including:

• fibrosis of organs comprising:

> all forms of lung / pulmonary fibrosis including all forms of fibrosing interstitial lung diseases, especially idiopathic pulmonary fibrosis (alternatively named cryptogenic fibrosing alveolitis); pulmonary fibrosis secondary to systemic inflammatory disease such as rheumatoid arthritis, scleroderma (systemic sclerosis, SSc), lupus (systemic lupus erythematosus, SLE), polymyositis, or mixed connective tissue disease (MCTD); pulmonary fibrosis secondary to sarcoidosis; iatrogenic pulmonary fibrosis including radiation-induced fibrosis; silicosis-induced pulmonary fibrosis; asbestos-induced pulmonary fibrosis; and pleural fibrosis;

> renal / kidney fibrosis, including renal fibrosis caused by / associated with chronic kidney disease (CKD), (acute or chronic) renal failure, tubulointerstitial nephritis, and/or chronic nephropathies such as (primary) glomerulonephritis and glomerulonephritis secondary to systemic inflammatory diseases such as SLE or SSc, diabetes, focal segmental glomerular sclerosis, IgA nephropathy, hypertension, renal allograft, and Alport syndrome;

> all forms of liver / hepatic fibrosis (associated or not with portal hypertension) including cirrhosis, alcohol- induced liver fibrosis, nonalcoholic steatohepatitis, biliary duct injury, primary biliary cirrhosis (also known as primary biliary cholangitis), infection- or viral-induced liver fibrosis (e.g. chronic HCV infection), and autoimmune hepatitis;

> all forms of heart / cardiac fibrosis, including heart / cardiac fibrosis associated with cardiovascular diseases, heart failure, Fabry disease, CKD; diabetes, hypertension, or hypercholesterolemia;

> gut fibrosis, including gut fibrosis secondary to SSc, and radiation-induced gut fibrosis;

> skin fibrosis, including SSc and skin scarring;

> head and neck fibrosis, including radiation-induced head and neck fibrosis;

> eye / corneal fibrosis, including scarring (e.g. sequelae of laser-assisted in situ keratomileusis, or trabeculectomy);

> hypertrophic scarring and keloids, including burn-induced or surgical hypertrophic scarring and keloids;

> fibrosis sequelae of organ transplant (including corneal transplant);

> and other fibrotic diseases including endometriosis, spinal cord fibrosis, myelofibrosis, perivascular and aterial fibrosis; as well as formation of scar tissue, Peyronie's disease, abdominal or bowel adhesions, bladder fibrosis, fibrosis of the nasal passages, and fibrosis mediated by fibroblasts;

• (acute or chronic) liver diseases and disorders including acute and chronic viral hepatitis; cirrhosis caused by / associated with arthritis and vasculitis; metabolic liver diseases caused by / associated with arthritis, myocarditis, diabetes, or neurologic symptoms; cholestatic diseases caused by / associated with hyperlipidaemia, inflammatory bowel disease (IBD), or ulcerative colitis; liver tumors; autoimmune hepatitis and cirrhosis caused by / associated with celiac disease, autoimmune haemolytic anaemia, IBD, autoimmune thyroiditis, ulcerative colitis, diabetes, glomerulonephritis, pericarditis, autoimmune thyroiditis, hyperthyroidism, polymyositis, Sjorgen syndrome, panniculitis, alveolitis or alcoholic steatosis; cirrhosis associated with dementia; cirrhosis associated with peripheral neuropathy; cirrhosis caused by / associated with oral or oesophageal cancer; non-alcoholic fatty liver disease (especially non-alcoholic steatohepatitis) caused by / associated with obesity, metabolic syndrome or type 2 diabetes; hepatic blood vessel disorders (including Budd-Chiari syndrome, portal vein thrombosis, sinusoidal obstruction syndrome); acute and chronic liver failure (associated or not with portal hypertension); liver hypofunction;

• acute kidney injury and chronic kidney disease (CKD) [especially CKD of stages 1 to 5 as defined by the Kidney Disease Improving Global Outcomes (KDIGO) Guidelines], in particular CKD (notably of these stages) caused by / associated with cardiac diseases (also referred to as cardio-renal syndrome type 1 and type 2), or caused by / associated with hypertension, or caused by / associated with diabetes (also referred to as diabetic kidney disease (DKD), including DKD associated with hypertension), wherein such diabetes especially is type 1 or type 2 diabetes), or caused by / associated with inflammatory diseases and disorders (such as glomerulonephritis and glomerulonephritis secondary to systemic inflammatory diseases such as SLE or SSc, tubulo-interstitial nephritis, vasculitis, sepsis, urinary tract infection), or caused by / associated with polycystic kidney disease, or caused by / associated with obstructive nephropathy (including calculi, benign prostatic hyperplasia, prostate cancer, retroperitoneal pelvic tumor), or caused by / associated with symptoms associated with neuropathic bladder disease); as well as acute and chronic renal failure;

• cardiovascular diseases and disorders (including atherosclerosis caused by / associated with hypertension, hypercholesterolemia, diabetes, inflammation, obesity, elderly/age; peripheral arterial disease caused by / associated with hypertension, hypercholesterolemia, diabetes, elderly/age; deep venous thrombosis; pulmonary embolism caused by / associated with obesity or cancer; aortic aneurysm and dissection caused by / associated with elderly/age, hypertension, Marfan syndrome, congenital heart disorders, inflammatory or infectious disorders; cerebrovascular disease caused by / associated with hypertension, atrial fibrillation, hypercholesterolemia, diabetes, elderly/age; coronary heart disease caused by / associated with hypertension, hypercholesterolemia, diabetes, elderly/age, or CKD (especially CKD of stages 1 to 5 as defined by the Kidney Disease Improving Global Outcomes (KDIGO) Guidelines); rheumatic heart disease caused by / associated with bacterial infection; heart and vascular tumors; cardiomyopathy and arrythmias; valvular heart disease (including valvular calcification and degenerative aortic stenosis); inflammatory heart disease caused by / associated with infection, carditis, glomerulonephitis, cancer; heart failure (HF) defined as including especially congestive HF, including in particular systolic HF / HF with reduced ejection fraction (HFrEF), and diastolic HF / HF with preserved ejection fraction (HFpEF);

• interstitial lung diseases and disorders (including smoking-related interstitial lung disease; interstitial lung disease associated with / caused by chronic obstructive pulmonary disease; interstitial pneumonia associated with collagen vascular disease (including usual interstitial pneumonia), or pneumonia);

• cell proliferative diseases and cancers (including solid tumors, solid tumor metastasis, carcinoma, sarcoma, myeloma (and multiple myeloma), leukemia, lymphoma, mixed types of cancers, vascular fibroma, Kaposi's sarcoma, chronic lymphocytic leukemia (CLL), spinal cord tumors and invasive metastasis of cancer cells);

• inflammatory and autoimmune diseases and disorders including chronic and acute inflammatory and autoimmune diseases and disorders (in particular including sepsis, Q-fever, asthma, rheumatoid arthritis, multiple sclerosis, SLE, SSc, polymyositis, plaque psoriasis (including psoriasis caused by / associated with NASH), atopic dermatitis, inflammatory renal / kidney diseases such as nephropathy (including diabetic nephropathy, glomerulonephritis, tubulointerstitial nephritis), inflammatory cardiac / heart diseases, inflammatory lung / lung related diseases; inflammatory liver / liver related diseases; diabetes (type 1 or type 2) and diabetes related diseases such as diabetic vasculopathy, diabetic nephropathy, diabetic retinopathy, diabetic peripheral neuropathy or skin related condition; viral encephalitis; and COVID-19 and sequelae thereof);

• gastrointestinal tract diseases and disorders (including irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), gastritis, and abnormal pancreatic secretion);

• pancreatic diseases and disorders (including pancreatitis, e.g. associated with cystic fibrosis);

• abnormal angiogenesis-associated diseases and disorders (including arterial obstruction);

• brain-associated diseases and disorders (including stroke and cerebral haemorrhage);

• neuropathic pain and peripheral neuropathy;

• ocular diseases and disorders (including dry eye disease (dry eye syndrome), macular degeneration (AMD associated with age, diabetes related disease (diabetic retinopathy), proliferative vitreoretinopathy (PVR), cicatricial pemphigoid, and glaucoma (including glaucoma associated with elevated intraocular pressure, and ocular scarring after glaucoma filtration surgery), and corneal angiogenesis/neovascularization); and

• transplant rejection comprising rejection of transplanted organs such as kidney, liver, heart, lung, pancreas, cornea, and skin; graft-versus-host diseases brought about by hematopoietic stem cell transplantation; chronic allograft rejection and chronic allograft vasculopathy; and sequelae of such transplant rejection.

22) A further embodiment relates to the compounds of formula (I) for use according to embodiment 21) wherein said compounds are for use in the prevention / prophylaxis or treatment of fibrosis of organs including liver / hepatic fibrosis , renal / kidney fibrosis, lung / pulmonary fibrosis .heart / cardiac fibrosis, eye / corneal fibrosis, and skin fibrosis ; as well as gut fibrosis, head and neck fibrosis, hypertrophic scarring and keloids; and fibrosis sequelae of organ transplant. 23) A further embodiment relates to the compounds of formula (I) for use according to embodiment 21) wherein said compounds are for use in the prevention / prophylaxis or treatment of cardiovascular diseases and disorders.

24) A further embodiment relates to the compounds of formula (I) for use according to embodiment 21) wherein said compounds are for use in the prevention / prophylaxis or treatment of acute kidney injury and chronic kidney disease (CKD).

25) A further embodiment relates to the compounds of formula (I) for use according to embodiment 21) wherein said compounds are for use in the prevention / prophylaxis or treatment of (acute or chronic) liver diseases and disorders.

26) A further embodiment relates to the compounds of formula (I) for use according to embodiment 21) wherein said compounds are for use in the prevention / prophylaxis or treatment of interstitial lung diseases and disorders.

27) A further embodiment relates to the compounds of formula (I) for use according to embodiment 21) wherein said compounds are for use in the prevention / prophylaxis or treatment of ocular diseases and disorders.

28) A further embodiment relates to the compounds of formula (I) for use according to embodiment 21) wherein said compounds are for use in the prevention / prophylaxis or treatment of cell proliferative diseases and cancers.

29) A further embodiment relates to the compounds of formula (I) for use according to embodiment 21) wherein said compounds are for use in the prevention / prophylaxis or treatment of chronic or acute inflammatory and autoimmune diseases and disorders.

30) A further embodiment relates to the compounds of formula (I) for use according to embodiment 21) wherein said compounds are for use in the prevention / prophylaxis or treatment of gastrointestinal tract diseases and disorders.

31) A further embodiment relates to the compounds of formula (I) for use according to embodiment 21) wherein said compounds are for use in the prevention / prophylaxis or treatment of pancreatic diseases and disorders.

32) A further embodiment relates to the compounds of formula (I) for use according to embodiment 21) wherein said compounds are for use in the prevention / prophylaxis or treatment of abnormal angiogenesis-associated diseases and disorders.

33) A further embodiment relates to the compounds of formula (I) for use according to embodiment 21) wherein said compounds are for use in the prevention / prophylaxis or treatment of brain-associated diseases and disorders.

34) A further embodiment relates to the compounds of formula (I) for use according to embodiment 21) wherein said compounds are for use in the prevention / prophylaxis or treatment of neuropathic pain and peripheral neuropathy.

35) A further embodiment relates to the compounds of formula (I) for use according to embodiment 21) wherein said compounds are for use in the treatment of transplant rejection. Preparation of compounds of Formula (I):

The compounds of Formula (I) can be prepared by well-known literature methods, by the methods given below, by the methods given in the experimental part below or by analogous methods. Optimum reaction conditions may vary with the particular reactants or solvents used, but such conditions can be determined by a person skilled in the art by routine optimisation procedures. In some cases the order of carrying out the following reaction schemes, and/or reaction steps, may be varied to facilitate the reaction or to avoid unwanted by-products. In the general sequence of reactions outlined below, the integer n and the generic groups R ¹ , L, Ar ¹ , and Ar ² are as defined for Formula (I). Other abbreviations used herein are explicitly defined, or are as defined in the experimental section. In some instances the generic groups R ¹ , L, Ar ¹ , and Ar ² might be incompatible with the assembly illustrated in the schemes below and so will require the use of protecting groups (Pg). The use of protecting groups is well known in the art (see for example "Protective Groups in Organic Synthesis", T.W. Greene, P.G.M. Wuts, Wiley-lnterscience, 1999). For the purposes of this discussion, it will be assumed that such protecting groups as necessary are in place. In some cases the final product may be further modified, for example, by manipulation of substituents to give a new final product. These manipulations may include, but are not limited to, reduction, oxidation, alkylation, acylation, hydrolysis and transition-metal catalysed cross- coupling reactions which are commonly known to those skilled in the art. The compounds obtained may also be converted into salts, especially pharmaceutically acceptable salts, in a manner known perse.

Compounds of the Formula (I) of the present invention can be prepared according to the general sequence of reactions outlined below. Only a few of the synthetic possibilities leading to compounds of Formula (I) are described.

Compounds of Formula (I) are prepared by coupling a compound of Structure 1 where R is either hydrogen, a suitable protective group (Pg) or R ¹ (as defined in Formula (I)) with a compound of Structure 2 to give Structure 3. The coupling reaction is performed using standard peptide coupling conditions such as DCC, HOBT, or T3P in presence of a base such as TEA or DI PEA in a suitable solvent such as DCM or DMF or mixtures thereof. Alternatively, POCI3 can be used with pyridine as a base. In Structure 2 and 3, Pg is a suitable protective group such as acetyl, trimethylsilyl (TMS) or tert-butyl dimethylsilyl (TBS), or benzyl, which are well known to the person skilled in the art. The hydroxy groups in position 4 and 6 of Structure 1 can be protected with cyclic protective groups such as isopropylidene, benzylidene or bis-tert-butyl silyl groups. R is either hydrogen, a suitable protective group (Pg) or R ¹ (as defined in Formula (I)). Compounds of Structure 3 are then deprotected to yield compounds of Formula (I).

In the case Pg represents an acyl protective group, such a protective group can be cleaved under standard conditions, e.g. by water or an alcohol in the presence or absence of additional solvents such as THF, dioxane, etc. and in the presence of a base such as K ₂ CO ₃ , NaOH, LiOH. In the case wherein such a protective group represents a benzyl group, the protective group can be cleaved e.g. by hydrogen in the presence of a catalyst such as Pd/C, PtO ₂ in methanol, EA, THF, etc. or mixtures thereof, or by BBr ₃ in a solvent such as DCM. In the case wherein such a protective group is TMS or TBS, the protective group is cleaved using fluoride ions such as TBAF of HF in pyridine. Alternatively, silyl protective groups are removed under mild acidic conditions such as aqueous acetic acid at temperatures between rt and reflux. In the case where Pg is a cyclic protective group such as isopropylidene, benzylidene and bis-tert-butyl silylene group, the cleavage can be performed under acidic conditions using aqueous acetic acid or TFA.

The compounds of Structure 1 are prepared by hydrolysis of the nitrile function in Structure 4 to the carboxylic acid using aqueous acidic (cone. HCI) or basic (NaOH) conditions at temperatures between 20 and 100°C, followed by suitable protection or modification of the free hydroxyl groups. Structure 4 in turn is obtained e.g. by reacting a compound of Structure 5 with a compound of Structure 6 in the presence of Cul and DIPEA in solvents such as THF or DMF (Click Chemistry in Glycoscience: New Development and Strategies, 1st Edition, 2013, John Wiley& Sons), alternatively the reaction can be run on a commercial continuous-flow reactor (Vapourtec) using a copper coil in a solvent such as THF. Compounds of Structure 6 are either commercially available or can be prepared according to procedures known to a person skilled in the art ( Synthesis 2011, 22, 3604-3611). Compounds of Structure 5 can be prepared from corresponding gulofuranose derivatives through methods well known to a person skilled in the art (' Carbohydrate Research 1994, 251, 33-67; Bioorg. Med. Chem. 2002, 10, 1911-2013).

Compounds of Structure 2 are obtained by protection of compounds of Structure 7 with a suitable silyl-based protective group under standard conditions. Compounds of Structure 7 are obtained by functionalization of (1S,2S)- trans-2-aminocyclohexanol or (1S,2S)-trans-2-aminocycloheptanol e.g. by reductive amination using a suitable carbonyl component and a reducing agent such as NaB(OAc) ₃ H or NaCNBH ₃ in a suitable solvent such as DCM, MeOH , THF, DMF or mixtures thereof. Alternatively, compounds of Structure 7 are obtained by reaction of cyclohexene oxide or cycloheptene oxide with an amine. This reaction either yields racemic trans-aminoalcohols or when carried out with a suitable catalyst such as reported in Org. Lett. 2014, 16, 2798-2801, the enantiomerically enriched derivatives. In the case that compounds of Structure 7 are used in racemic form, the diastereomers of Structure 3 or Formula 1 can be separated after the coupling with compounds of Structure 1 using techniques which are well known to the person skilled in the art, such as chiral preparative HPLC or column chromatography on SiO ₂ .

Whenever the compounds of Formula (I) are obtained in the form of mixtures of stereoisomers, the stereoisomers can be separated by preparative HPLC using achiral or chiral stationary phases such as a Waters XBridge C18, 10 mm OBD, 30x75 mm, or Daicel ChiralCel OJ-H (5-10 mm) column, a Daicel ChiralPak IH (5 mm) or AS-H (5 mm) or IB (5 mm) column, respectively. Typical conditions of chiral HPLC are an isocratic mixture of eluent A (CO2) and eluent B (DCM/MeOH, 0.1% Et ₂ NH in EtOH, MeOH, EtOH), at a flow rate of 0.8 to 160 mL/min).

Experimental Part

The following examples illustrate the invention but do not at all limit the scope thereof.

All temperatures are stated in °C. Commercially available starting materials were used as received without further purification. Unless otherwise specified, all reactions were carried out under an atmosphere of nitrogen or argon. Compounds were purified by flash chromatography on silica gel (Biotage), by prep TLC (TLC-plates from Merck, Silica gel 60 F254) or by preparative HPLC. Compounds described in the invention are characterized by ¹ H-NMR (Bruker Avance II, 400 MHz Ultra ShieldTM or Brooker Avance III HD, Ascend 500 MHz); chemical shifts are given in ppm relative to the solvent used; multiplicities: s = singlet, d = doublet, t = triplet, q = quadruplet, quint = quintuplet, hex = hexet, hept = heptet, m = multiplet, br = broad, coupling constants are given in Hz) and/or by LCMS (retention time tR is given in min; molecular weight obtained for the mass spectrum is given in g/mol) using the conditions listed below.

Characterization methods used: The LC-MS retention times have been obtained using the following elution conditions:

A) LC-MS (A):

Zorbax RRHD SB-Aq, 1 ,8 m, 2.1x50 mm column thermostated at 40°C. The two elution solvents were as follows: solvent A= water + 0.04% TFA; solvent B = acetonitrile. The eluent flow rate was 0.8 mL/min and the characteristics of the eluting mixture proportion in function of the time t from start of the elution are summarized in the table below (a linear gradient being used between two consecutive time points):

Detection: UV at 210 nm. B) LC-MS (B):

Waters BEH C18, 1 ,8 m, 1.2*50 mm column thermostated at 40°C. The two elution solvents were as follows: solvent A= water + 13mM NH40H; solvent B = acetonitrile. The eluent flow rate was 0.8 mL/min and the characteristics of the eluting mixture proportion in function of the time t from start of the elution are summarized in the table below (a linear gradient being used between two consecutive time points):

Detection: UV at 210 nm. D) LC-MS (D): Acquity UPLC CSH C18 1.7 um, 2.1 x 50 mm from Waters column thermostated at 60°C. The two elution solvents were as follows: solvent A= water + 0.05% Formic Acid; solvent B = acetonitrile. The eluent flow rate was 1 mL/min and the characteristics of the eluting mixture proportion in function of the time t from start of the elution are summarized in the table below (a linear gradient being used between two consecutive time points):

Detection: UV 214 nm. E) LC-MS (E):

Acquity UPLC CSH C18 1.7 um, 2.1 x 50 mm from Waters column thermostated at 60°C. The two elution solvents were as follows: solvent A= water + 0.05% Formic acid; solvent B = acetonitrile + 0.045% Formic acid. The eluent flow rate was 1 mL/min and the characteristics of the eluting mixture proportion in function of the time t from start of the elution are summarized in the table below (a linear gradient being used between two consecutive time points):

Detection: UV 214 nm

The purifications by preparative LC-MS have been performed using the conditions described hereafter.

C) Preparative LC-MS (I):

A Waters column (Waters XBridge C18, 10 mm OBD, 30x75 mm) was used. The two elution solvents were as follows: solvent A = water + 0.5% of a solution of 25% NH40H in water; solvent B = acetonitrile. The eluent flow rate was 75 mL/min and the characteristics of the eluting mixture proportion in function of the time t from start of the elution are summarized in the tables below (a linear gradient being used between two consecutive time points):

Detection 210 nm.

Abbreviations (as used herein):

ABTS 2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid

AcOH acetic acid aq. aqueous

Bu butyl (such as in nBuLi = n-butyl lithium)

Ca circa

CC column chromatography on silica cone. Concentrated

CSA 10-Camphorsulfonic acid

DBU 1,8-diazabicyclo[5.4.0]undec-7-ene

DCM dichloromethane

DEAD diethyl azodi carboxyl ate

DIPEA N-ethyl diisopropyl amine

DMAP 4-dimethylamino pyridine

DMF dimethylformamide DMSO dimethylsulfoxide

EA ethyl acetate

EDC HCI N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride eq (molar) equivalent(s)

Et ethyl

EtOH ethanol

Et ₂ O diethyl ether

FC flash chromatography h hour(s)

HATU 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyri dinium 3-oxid hexafluorophosphate

Hept heptane

HOBt 1-hydroxybenzotriazole hydrate

HPLC high performance liquid chromatography hv high vacuum

LAH lithium aluminium hydride

LDA lithium diisopropylamide

LC liquid chromatography

M molarity [mol L ^-1 ]

Me methyl

MeCN acetonitrile

MeOH methanol

MS mass spectroscopy min minute(s)

N normality

NaOMe sodium methoxide

NaOfBu sodium tert. (tertiary) butoxide

OD optical density o/n over night org. organic p-ABSA p-acetamidobenzenesulfonyl azide

Pd(Ph ₃ ) ₄ tetrakis(triphenylphosphine)pailadium(0)

PPh ₃ triphenylphosphine

Ph phenyl

PTSA p-Toluenesulfonic acid rt room temperature sat. saturated

TBME tert-butylmethylether

TBTU O-benzotriazol-1-yl-N,N,N',N'-tetramethyluronium tetrafluoroborate tBu tert-butyl = tertiary butyl

TEA triethylamine

Tf trifluoromethanesulfonate

TFA trifluoroacetic acid

THF tetrahydrofuran

TMS trimethylsilyl

T3P propylphosphonic anhydride t _R retention time

A- Preparation of precursors and intermediates

The following precursors have been prepared for the synthesis of the compounds:

Intermediate 1 : (3R,4S,5R,6R)-6-(Acetoxymethyl)-4-azidotetrahydro-2H-pyran-2 ,3,5-triyl triacetate

(3R,4S,5R,6R)-6-(acetoxymethyl)-4-azidotetrahydro-2H-pyra n-2,3,5-triyl triacetate is synthesized from (3aR,5S,6S,6aR)-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-d imethyltetrahydrofuro[2,3-d][1,3]dioxol-6-ol following the literature procedures from Ref: Carbohydrate Research 1994, 251, 33-67 and references cited therein.

Intermediate 2: (2R,3R,4R,5R,6S)-2-(acetoxymethyl)-6-cyano-4-(4-(3,4,5-trifl uorophenyl)-1H-1,2,3-triazol-1- yl)tetrahydro-2H-pyran-3,5-diyl diacetate

Intermediate 1 (10000 mg, 26.5 mmol, 1 eq) is dissolved in nitromethane (4 vol.) (40 mL) and trimethylsilyl cyanide 98% (10.2 mL, 79.6 mmol, 3 eq) and boron trifluoride diethyl etherate (3.93 mL, 31.8 mmol, 1.2 eq) are added portionwise over 30 min. Temperature is kept below 35°C with a water bath. The mixture is stirred at rt for 2h. The mixture is partitioned between water (400 mL), sat aq. bicarbonate (100 mL) and TBME (300 mL). The aq phase is extracted once more with TBME (200 mL) and org. phases washed twice with water/brine (ca. 5:1) and brine, dried over MgSO ₄ TBME is evaporated on Rotavap at 20°C. The crude intermediate is purified by filtration over S1O2 (150 mLcartridge filled 3/4, DCM/TBME 10:1). The intermediate is used immediately in the next step. 1H NMR (500 MHz, DMSO) d: 5.47 (dd, J ¹ = 0.7 Hz, J ² = 3.2 Hz, 1H), 5.17 (t, J = 10.3 Hz, 1H), 5.04 (d, J = 10.1 Hz, 1H), 4.22 (dd, J ¹ = 3.2 Hz, J ² = 10.4 Hz, 1H), 4.15 (ddd, J ¹ = 0.8 Hz, J ² = 4.5 Hz, J ³ = 7.2 Hz, 1H), 4.03-4.08 (m, 1 H), 3.97 (dd, J ¹ = 7.4 Hz, J ² = 11.7 Hz, 1H), 2.18 (s, 3 H), 2.15 (m, 3 H), 2.04 (s, 3 H)

Intermediate 3a: (2R,3R,4R,5R,6S)-2-(acetoxymethyl)-6-cyano-4-(4-(3,4,5-trifl uorophenyl)-1H-1,2,3-triazol-1- yl)tetrahydro-2H-pyran-3,5-diyl diacetate

Intermediate 2 is dissolved in DMF (80 mL) and 5-ethynyl-1,2,3-trifluorobenzene (312 mg, 21.2 mmol, 0.8 eq), DIPEA (13.6 mL, 79.6 mmol, 3 eq) and Cul (505 mg, 2.65 mmol, 0.1 eq) are added under N ₂ . The yellow mixture is stirred at rt for 1 h. Exothermic. The yellow solution is slowly poured on water (800 mL) and stirred for 10 min. The beige precipitate is filtered off and the filtrate discarded. The beige solid is washed with MeOH and then dissolved in EA (300 mL) and stirred for 10 min. The fine Cu residues are filtered off and the filtrated is washed with NH4CI solution (half saturated) and brine, dried over MgSO ₄ and concentrated. The residue is triturated with MeOH (ca 100 mL), filtered and dried at hv to give the desired intermediate 3a as a beige solid

¹ H NMR (500 MHz, DMSO-d6) d: 8.85 (s, 1H), 7.81-7.85 (m, 2 H), 5.91 (m, 1H), 5.64 (dd, J1 = 3.1Hz, J2 = 11.0 Hz, 1H), 5.51 (dd, J1 = 0.7 Hz, J2 = 3.0 Hz, 1H), 5.24 (d, J = 9.9 Hz, 1H), 4.43-4.46 (m, 1H), 4.03-4.12 (m, 2 H), 2.10 (s, 3 H), 2.04 (m, 3 H), 1 .94 (m, 3 H). LCMS (A): t _R = 0.86 min; [M+H] ⁺ = 577.28

Intermediate 3b: (2R,3R,4R,5R,6S)-2-(acetoxymethyl)-6-cyano-4-(4-(3,5-difluor ophenyl)-1H-1,2,3-triazol-1- yl)tetrahydro-2H-pyran-3,5-diyl diacetate

Prepared in analogy to Intermediate 3a using the appropriate alkyne derivative (commercial). LCMS (A): t _R = 0.95 min; [M+H]+ = 479.23

Intermediate 3c: (2R,3R,4R,5R,6S)-2-(acetoxymethyl)-4-(4-(4-chloro-3,5-difluo rophenyl)-1H-1,2,3-triazol-1-yl)-6- cyanotetrahydro-2H-pyran-3,5-diyl diacetate

Prepared in analogy to Intermediate 3a using the appropriate alkyne derivative (commercial). LCMS (A): t _R = 1.00 min; [M+H]+ = 513.28

Intermediate 3d: (2R,3R,4R,5R,6S)-2-(acetoxymethyl)-6-cyano-4-(4-(3,5-difluor o-4-methylphenyl)-1H-1,2,3- triazol-1-yl)tetrahydro-2H-pyran-3,5-diyl diacetate

Prepared in analogy to Intermediate 3a using the appropriate alkyne derivative (commercial). LCMS (A): t _R = 0.98 min; [M+H]+ = 493.26 Intermediate 3e: (2R,3R,4R,5R,6S)-2-(acetoxymethyl)-6-cyano-4-(4-(3-fluorophe nyl)-1H-1,2,3-triazol-1- yl)tetrahydro-2H-pyran-3,5-diyl diacetate

Prepared in analogy to Intermediate 3a using the appropriate alkyne derivative (commercial). LCMS (A): t _R = 0.91 min; [M+H]+ = 461.18 Intermediates 3 are further functionalised as shown in the scheme below

Intermediate 4a: (2R,3R,4S,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-(4-(3,4,5 -trifluorophenyl)-1H-1,2,3- triazol-1-yl)tetrahydro-2H-pyran-2-carboxylic acid Intermediate 3a (2800 mg, 5.64 mmol, 1 eq) is suspended in HCI 25% (20.6 mL, 169 mmol, 30 eq) and heated at reflux for 1.5h. The solution is applied to a MCI ® gel column (ca 100 mL gel) under water. The column is eluted with water until neutral pH (5 fractions a 40 mL). The compound is then eluted with H ₂ O/MeCN (3:1). Fractions of 40 mL are taken. Fractions containing product are first concentrated in vacuo to remove MeCN and then freeze-dried to give the title compound as a colourless solid. LCMS (A): t _R = 0.59 min; [M+H]+ = 390.22

¹ H NMR (500 MHz, DMSO-d6) d: 12.88-12.90 (br, 1H), 8.79 (s, 1H), 7.86 (dd, J ¹ = 6.8 Hz, J ² = 9.1Hz, 2 H), 5.43- 5.46 (m, 1H), 5.30 (d, J = 6.2 Hz, 1H), 4.84 (dd, J ¹ = 3.0 Hz, J ² = 10.8 Hz, 1H), 4.72 (d, J = 0.5 Hz, 1H), 4.36 (t, J = 10.0 Hz, 1H), 3.94 (dd, J ¹ = 3.0 Hz, J ² = 6.0 Hz, 1H), 3.85 (d, J = 9.4 Hz, 1H), 3.71 (t, J = 6.5 Hz, 1H), 3.48-3.55 (m, 2 H)

Intermediate 4b: (2R,3R,4S,5R,6R)-4-(4-(3,5-difluorophenyl)-1H-1,2,3-triazol- 1-yl)-3,5-dihydroxy-6-

(hydroxymethyl)tetrahydro-2H-pyran-2-carboxylic acid

Prepared in analogy to Intermediate 4a. LCMS (A): tR = 0.55 min; [M+H]+ = 371.90

Intermediate 4c: (2R,3R,4S,5R,6R)-4-(4-(4-chloro-3,5-difluorophenyl)-1H-1,2,3 -triazol-1-yl)-3,5-dihydroxy-6- (hydroxymethyl)tetrahydro-2H-pyran-2-carboxylic acid

Prepared in analogy to Intermediate 4a. LCMS (A): t _R = 0.64 min; [M+H]+ = 406.20

Intermediate 4d: (2R,3R,4S,5R,6R)-4-(4-(3,5-difluoro-4-methylphenyl)-1H-1,2,3 -triazol-1-yl)-3,5-dihydroxy-6- (hydroxymethyl)tetrahydro-2H-pyran-2-carboxylic acid

Prepared in analogy to Intermediate 4a. LCMS (A): t _R = 0.61 min; [M+H]+ = 386.17

Intermediate 4e: (2R,3R,4S,5R,6R)-4-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl )-3,5-dihydroxy-6-

(hydroxymethyl)tetrahydro-2H-pyran-2-carboxylic acid

Prepared in analogy to Intermediate 4a. LCMS (A): t _R = 0.50 min; [M+H]+ = 354.11

Intermediate 5a: (4aR,6R,7R,8R)-7-hydroxy-2,2-dimethyl-8-(4-(3,4,5-trifluorop henyl)-1H-1,2,3-triazol-1- yl)hexahydropyrano[3,2-d][1,3]dioxine-6-carboxylic acid

Intermediate 4a (1780 mg, 4.57 mmol, 1 eq) is dissolved in THF (80 mL) and 2,2-dimethoxypropane (1.17 mL, 9.14 mmol, 2 eq) is added followed by PTSA monohydrate (16.1 mg, 0.0914 mmol, 0.02 eq) at rt.

The mixture is heated to 75°C for 1 ,5h and 20-25 mL solvent are distilled off using a Dean-Stark. The solution is cooled to rt and is then diluted with EA and washed with 10% citric acid solution, water and brine. The org. layer is dried over MgSO ₄ , filtered and concentrated under reduced pressure to give the title intermediate as a beige solid.

LCMS (A): t _R = 0.8 min; [M+H]+ = 430.20 1H NMR (500 MHz, DMSO) d: 12.85-13.10 (m, 1H), 8.67 (s, 1H), 7.88 (dd, J ¹ = 9.1Hz, J ² = 6.8 Hz, 2 H), 5.45-5.59 (m, 1H), 4.98 (dd, J ¹ = 10.7 Hz, J ² = 3.4 Hz, 1H), 4.32-4.38 (m, 2 H), 4.01-4.03 (m, 1H), 3.94 (d, J = 9.3 Hz, 1 H), 3.71-3.76 (m, 2 H), 1.32 (s, 3 H), 1.21 (s, 3 H)

Intermediate 5b: (4aR,6R,7R,8R,8aR)-8-(4-(3,5-difluorophenyl)-1H-1,2,3-triazo l-1-yl)-7-hydroxy-2,2- dimethylhexahydropyrano[3,2-d][1,3]dioxine-6-carboxylic acid

Prepared in analogy to Intermediate 5a. LCMS (A): t _R = 0.76 min; [M+H] ⁺ = 412.29 Intermediate 5c: (4aR,6R,7R,8R,8aR)-8-(4-(4-chloro-3,5-difluorophenyl)-1H-1,2 ,3-triazol-1-yl)-7-hydroxy-2,2- dimethylhexahydropyrano[3,2-d][1,3]dioxine-6-carboxylic acid

Prepared in analogy to Intermediate 5a. LCMS (A): tR = 0.84 min; [M+H]+ = 446.24

Intermediate 5d: (4aR,6R,7R,8R,8aR)-8-(4-(3,5-difluoro-4-methylphenyl)-1H-1,2 ,3-triazol-1-yl)-7-hydroxy-2,2- dimethyl hexahydropyrano[3,2-d][1,3]dioxine-6-carboxylic acid

Prepared in analogy to Intermediate 5a. LCMS (A): t _R = 0.81 min; [M+H]+ = 426.27

Intermediate 5e: (4aR,6R,7R,8R,8aR)-8-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1- yl)-7-hydroxy-2,2- dimethylhexahydropyrano[3,2-d][1,3]dioxine-6-carboxylic acid

Prepared in analogy to Intermediate 5a. LCMS (A): t _R = 0.72 min; [M+H]+ = 394.19

Intermediate 6a: (4aR,6R,7R,8R,8aR)-7-methoxy-2,2-dimethyl-8-(4-(3,4,5-triflu orophenyl)-1H-1,2,3-triazol-1- yl)hexahydropyrano[3,2-d][1,3]dioxine-6-carboxylic acid

Step 1 : methyl (4aR, 6R, 7R, 8R, 8aR)-7-methoxy-2, 2-dimethyl-8-( 4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1- yl)hexahydropyrano[3, 2-d][1 ,3]dioxine-6-carboxylate

A solution of Intermediate 5a (3180 mg, 7.41 mmol, 1 eq) in DMF (dry) (14.8 mL) and THF (dry) (29.6 mL) is cooled to 0°C and dimethyl sulfate* 99.8% (1.44 mL, 15.2 mmol, 2.05 eq) is added followed by NaH (55% dispersion in mineral oil) (622 mg, 15.6 mmol, 2.1 eq). The mixture is stirred at 0°C for 30 min and then at rt for 3 h. The mixture is cooled to 0°C again and quenched by addition of sat. NH ₄ CI solution. The mixture is diluted with water and EA and the layers are separated. The org. layer is washed with water and brine and the aq. layer is once re-extracted with EA. The combined org. layers are dried over magnesium sulfate, filtrated and evaporated. The residue is precipitated from TBME/Hept and the colorless solid is filtered off and washed with little TBME and dried at hv. The desired methylester is isolated as a colourless solid.

LCMS (A): t _R = 0.98 min; [M+H]+ = 458.22

* lodomethane could be used as reagent as well delivering the same product.

Step 2: ( 4aR, 6R, 7R, 8R, 8aR)-7-methoxy-2, 2-dimethyl-8-( 4-( 3, 4, 5-trifluorophenyl) -1H-1,2,3-triazol- 1 - yl)hexahydropyrano[3,2-d][1,3]dioxine-6-carboxylic acid

The intermediate from step 1 (1546 mg, 3.38 mmol, 1 eq) is dissolved in THF/MeOH/H ₂ O 3:2:1 (34.1 mL) and lithiumhydroxide monohydrate (217 mg, 5.07 mmol, 1.5 eq) is added at rt.

The mixture is stirred at rt for 4h. The mixture is diluted with water, acidified with 0.1 N HCI and two times extracted with EA. The org. layers are washed with brine, combined, dried over magnesium sulfate, filtered and concentrated. The residue is triturated in TBME. The white solid is filtered off and washed with TBME and dried at hv to give the desired intermediate as a colourless solid.

LCMS (A): t _R = 0.87 min; [M+H]+ = 444.25

Intermediate 6b: (4aR,6R,7R,8S,8aR)-2,2-dimethyl-8-(4-(3,4,5-trifluorophenyl) -1H-1,2,3-triazol-1-yl)-7-

((trimethylsilyl)oxy)hexahydropyrano[3,2-d][1,3]dioxine-6 -carboxylic acid

To a solution of Intermediate 5a (2000 mg, 4.66 mmol, 1 eq) and 2,6-lutidine (0.192 mL, 1.63 mmol, 3.5 eq) in DCM dry (5 mL) is dropwise added trimethylsilyl trifluoromethanesulfonate (0.255 mL, 1.4 mmol, 3 eq) at 0°C. The mixture is stirred at 0°C for 4.5 h. 2,6-lutidine (1 .09 mL, 9.32 mmol, 2 eq) and trimethylsilyl trifluoromethanesulfonate (1 .69 mL, 9.32 mmol, 2 eq) are added again at 0°C and stirring is continued at 0°C. 2,6-lutidine (1.09 mL, 9.32 mmol, 2 eq) and trimethylsilyl trifluoromethanesulfonate (0.506 mL, 2.79 mmol, 0.6 eq) are added again and stirring continued for 1 h. The mixture is diluted with DCM and quenched with water at 0°C. The layers are separated and the org. one is washed with water and brine. The org. layer is filtered over a phase separator and evaporated. The crude is dried at hv and used without purification due to its instability.

Intermediate 6c: (4aR,6R,7R,8S,8aR)-7-((tert-butyldimethylsilyl)oxy)-2,2-dime thyl-8-(4-(3,4,5-trifluorophenyl)- 1H-1,2,3-triazol-1-yl)hexahydropyrano[3,2-d][1,3]dioxine-6-c arboxylic acid

To a solution of Intermediate 5a (50 mg, 0.116 mmol, 1 eq) in DCM dry (1 mL) under N ₂ at 0°C is added 2,6-lutidine (0.0274 mL, 0.233 mmol, 2 eq), followed by addition of tert-butyldimethylsilyl trifluoromethanesulfonate (0.03 mL, 0.128 mmol, 1.1 eq). The orange solution is then stirred at 0°C for 1 .5 h. The mixture is stirred at rt o/n. tert-butyldimethylsilyl trifluoromethanesulfonate (0.0267 mL, 0.116 mmol, 1 eq) and 2,6-lutidine (0.0271 mL, 0.233 mmol, 2 eq) are added again at 0°C and the mixture is stirred at 0°C for 1 h. The mixture is quenched with 10% citric acid and two times extracted with DCM. The combined org. layers are dried using a phase separator and are then concentrated under reduced pressure. The mixture is dissolved in MeCN/water 1/1 (1 mL) and is treated with HCOOH (0.5 mL). The suspension is stirred at rt for 1 h and is then filtered. The solid is purified by FC using CombiFlash (4 g Si0 ₂ column; gradient: hept to hept/EA 1/2 in 15 min) to give the desired product as a colourless solid.

LCMS (A): t _R = 1.07 min; [M+H]+ = 544.30

Intermediate 6d: (4aR,6R,7R,8S,8aR)-7-acetoxy-2,2-dimethyl-8-(4-(3,4,5-triflu orophenyl)-1H-1,2,3-triazol-1- yl)hexahydropyrano[3,2-d][1,3]dioxine-6-carboxylic acid

To a solution of Intermediate 5a (500 mg, 1.16 mmol, 1 eq) in DCM (11.6 mL) and TEA (0.648 mL, 4.66 mmol, 4 eq) is added Ac ₂ O (0.22 mL, 2.33 mmol, 2 eq) followed by DMAP (14.2 mg, 0.116 mmol, 0.1 eq). The mixture is stirred at rt o/n. The mixture is diluted with water and DCM. The pH is carefully adjusted to 5-6 with 10% citric acid and the layers are separated. The aq. layer is once reextracted with DCM and the combined org. layers are dried over MgSO ₄ , filtered and evaporated. The residue is precipitated from TBME/hept + little MeOH. The colourless solid is filtered off and washed with TBME to give the desired intermediate as a colourless solid.

LCMS (A): t _R = 0.87 min; [M+H]+ = 472.11

Intermediate 6e: (4aR,6R,7R,8S,8aR)-7-acetoxy-8-(4-(3,5-difluorophenyl)-1H-1, 2,3-triazol-1-yl)-2,2- dimethylhexahydropyrano[3,2-d][1,3]dioxine-6-carboxylic acid

Prepared form 5b in analogy to Intermediate 6d. LCMS (A): t _R = 0.83 min; [M+H]+ = 454.01

Intermediate 6f: (4aR,6R,7R,8S,8aR)-7-acetoxy-8-(4-(4-chloro-3,5-difluorophen yl)-1H-1,2,3-triazol-1-yl)-2,2- dimethylhexahydropyrano[3,2-d][1,3]dioxine-6-carboxylic acid

Prepared form 5c in analogy to Intermediate 6d. LCMS (A): t _R = 0.90 min; [M+H]+ = 487.96

Intermediate 6g: (4aR,6R,7R,8S,8aR)-7-acetoxy-8-(4-(3,5-difluoro-4-methylphen yl)-1H-1,2,3-triazol-1-yl)-2,2- dimethyl hexahydropyrano[3,2-d][1,3]dioxine-6-carboxylic acid

Prepared form 5d in analogy to Intermediate 6d. LCMS (A): t _R = 0.88 min; [M+H]+ = 468.09

Intermediate 6h: (4aR,6R,7R,8S,8aR)-7-acetoxy-8-(4-(3-fluorophenyl)-1H-1,2,3- triazol-1-yl)-2,2- dimethylhexahydropyrano[3,2-d][1,3]dioxine-6-carboxylic acid

Prepared form 5e in analogy to Intermediate 6d. LCMS (A): t _R = 0.79 min; [M+H]+ = 436.04

Intermediate 7a: (2R,3R,4S,5R,6R)-3,5-diacetoxy-6-(acetoxymethyl)-4-(4-(3,4,5 -trifluorophenyl)-1H-1,2,3- triazol-1-yl)tetrahydro-2H-pyran-2-carboxylic acid

To a suspension of Intermediate 4a (1500 mg, 3.85 mmol, 1 eq) in AC ₂ O (2.04 mL, 21.2 mmol, 5.5 eq) is added perchloric acid 70% in water (0.00831 mL, 0.0963 mmol, 0.025 eq) at 0°C. The mixture is stirred at 0°C for 5 min and then allowed to warm to rt and stirred o/n. The mixture is cooled to 0°C and diluted with water (50 mL) and THF (5 mL). The mixture is allowed to warm to rt (26°C, hydrolysis exothermic).

The mixture is cooled to 0-5°C and the precipitated product is filtered off, washed with water and dried at hv o/n to afford the product as a white solid.

LCMS (A): t _R = 0.85 min; [M+H]+ = 516.13

¹ H NMR (500 MHz, DMSO-d6) d: 13.38 (d, 1H), 8.84 (s, 1H), 7.70-7.95 (m, 2 H), 5.73 (dd, J ¹ = 11.0 Hz, J ² = 9.5 Hz), 5.67 (dd, J ¹ = 11.1Hz, J ² = 3.2 Hz), 5.42-5.45 (m, 1H), 4.37-4.42 (m, 1H), 4.36 (d, J = 9.5 Hz, 1H), 4.08 (dd, J ¹ = 11 .5 Hz, J ² = 5.6 Hz, 1H), 4.04 (dd, J ¹ = 11 .5 Hz, J ² = 7.0 Hz, 1H), 2.08 (s, 3 H), 2.01 (s, 3 H), 1 .82 (s, 3 H) Intermediate 8a: (2S,4aR,6R,7R,8R,8aR)-7-hydroxy-2-phenyl-8-(4-(3,4,5-trifluo rophenyl)-1H-1,2,3-triazol-1- yl)hexahydropyrano[3,2-d][1,3]dioxine-6-carboxylic acid

Intermediate 4a (1 g, 2.57 mmol) is dissolved in MeCN (50 mL). Benzaldehyde dimethylacetal (1 mL) is added followed by PTSA (0.035 g, 0.07 eq). The mixture is stirred at rtfor 16 h. Volatiles are removed under reduced pressure and the residue partitioned between EA and sat. NH4CI solution. The org phase is dried over MgSO ₄ and concentrated to give the desired intermediate as a colourless solid.

LCMS (A): t _R = 0.89 min; [M+H]+ = 478.17

¹ H NMR (500 MHz, DMSO-d6) d: 12.17-13.30 (m, 1H), 8.89 (s, 1H), 7.84 (dd, J ¹ = 9.0 Hz, J ² = 6.8 Hz, 2 H), 7.32- 7.36 (m, 4 H), 5.54 (s, 1H), 5.15 (dd, J ¹ = 10.7 Hz, J ² = 3.5 Hz, 1H), 4.45-4.52 (m, 2 H), 4.08-4.16 (m, 2 H), 4.02 (d, J = 9.4 Hz, 1H), 3.93 (m, 1H)

Intermediate 9a: (2S,4aR,6R,7R,8S,8aR)-7-acetoxy-2-phenyl-8-(4-(3,4,5-trifluo rophenyl)-1H-1,2,3-triazol-1- yl)hexahydropyrano[3,2-d][1,3]dioxine-6-carboxylic acid

Intermediate 8a (1.13 g, 2.37 mmol, 1 eq) is dissolved in DCM (30 mL) and TEA (1.3 mL, 9.47 mmol, 4 eq) and acetic anhydride (0.447 mL, 4.73 mmol, 2 eq) are added. The mixture is stirred at rt o/n. Sat. NH ₄ CI solution (20 mL) is added and the resulting mixture is stirred at rt for 10 min. The resulting precipitate is filtered off and washed with DCM and water. The crude product is dried at hv still containing some salts. The solid is therefore washed with citric acid solution (10%) and water and dried again at hv.

LCMS (A): t _R = 0.94 min; [M+H]+ = 520.16

Preparation of intermediates of Structure 7 and Structure 2

Intermediates of Structure 7 are prepared by a) reductive amination of 2-aminocyclohexanol or 2-aminocycloheptanol with an aldehyde, b) by alkylation with an alkylhalogenide or c) by epoxide opening as shown below

Intermediate 10: (1S,2S)-2-((3-chlorobenzyl)amino)cyclohexan-1-ol

To a solution of cis-2-aminocyclohexanol hydrochloride (100 mg, 0.868 mmol, 1 eq) in DCM/MeOH 4/1 (2.5 mL) is added 3-chlorobenzaldehyde (0.109 mL, 0.955 mmol, 1.1 eq) at rt. To the resulting solution is added sodium cyanoborohydride (68.9 mg, 1.04 mmol, 1.2 eq) under nitrogen at rt and the solution is stirred at rt for 4 h. Sodium cyanoborohydride (28.7 mg, 0.434 mmol, 0.5 eq) is added again at rt and the mixture is stirred at rt overnight. The mixture is quenched with water and basified with 25% aq. NH4OH solution. The mixture is extracted twice with DCM and the combined org. layers are evaporated. The residue is re-dissolved in MeCN and basified with aq. 25% NH ₄ OH solution. The product is purified by prep LCMS (I). Product containing fractions are freeze-dried to give the desired amino alcohol as a colourless solid.

LCMS (A): t _R = 0.58 min; [M+H]+ = 240.25

The following intermediates are prepared in analogy the procedure of Intermediate 10:

Preparation of compounds of Structure 2 protected with a silyl protective group:

Compounds of Structure 7 can be further protected at the hydroxy group following the procedures below:

Intermediate 31: (1S,2S)-N-(2-(trifluoromethyl)benzyl)-2-((trimethylsilyl)oxy )cyclohexan-1-amine To a solution of Intermediate 15 (556 mg, 2.03 mmol, 1 eq) and 2,6-lutidine (0.479 mL, 4.07 mmol, 2 eq) in dry DCM (10 mL) at 0°C is dropwise added trimethylsilyl trifluoromethanesulfonate 99% (0.558 mL, 3.05 mmol, 1.5 eq). The mixture is stirred at 0°C for 5 min and then allowed to warm to rt. The mixture is quenched with water and extracted twice with DCM. The combined org. layers are dried using a phase separator and are then concentrated under reduced pressure. The crude is absorbed on isolute and purified by FC CombiFlash (12 g RediSep column, 0-100% EA in hept within 10 min) to give the title intermediate (545 mg) as a colourless oil.

LCMS (B): t _R = 1.41 min; [M+H]+ = 346.23

Intermediate 32: (1S,2S)-2-((tert-butyldimethylsilyl)oxy)-N-(2-(trifluorometh yl)benzyl)cyclohexan-1-amine

To a solution of Intermediate 15 (2000 mg, 7.32 mmol, 1 eq) and 2,6-lutidine (1.7 mL, 14.6 mmol, 2 eq) in dry DCM (80 mL) at 0°C is dropwise added tert-butyldimethylsilyl trifluoromethanesulphonate (2.52 mL, 11 mmol, 1.5 eq). The mixture is stirred at 0°C for 5 min and then allowed to warm to rt. The mixture is quenched with water and extracted twice with DCM. The combined org. layers are dried using a phase separator and are then concentrated under reduced pressure. The crude is absorbed on isolute and purified by FC CombiFlash (40 g RediSep column, 0-100% EA in hept within 10 min) to give the title intermediate as a yellowish oil.

LCMS (A): t _R = 0.96 min; [M+H]+ = 388.27 The following intermediates are prepared in analogy:

Intermediate 53: (1S,2S)-2-(((4-(trifluoromethyl)pyrimidin-5-yl)methyl)amino) cyclohexan-1-ol

Step 1: (4-(trifluoromethyl)pyrimidin-5-yl)methanol

4-(Trifluoromethyl)pyrimidine-5-carboxylic acid (1000 mg, 5.21 mmol, 1 eq) is dissolved in THF (26 mL, 26 mmol, 5 eq) and cooled to -10°C (dry ice bath). 4-Methylmorpholine (1.17 mL, 10.4 mmol, 2 eq) is added at -15 to -10°C, followed by the addition of ethyl chloroformate (0.77 mL, 7.81 mmol, 1.5 eq) at an internal temperature of -20 to -10°C. THF (10 mL) is added slowly, keeping the internal temperature below -10°C to improve stirring. The mixture kept at -10°C for 30 min. After 30 min, sodium borohydride (761 mg, 19.5 mmol, 3 eq) is added at -10°C and stirring at this temperature is continued for 5 min. Then, the dry-ice bath is exchanged by an ice-bath and the mixture is stirred at 0°C for 1 h. The reaction mixture is quenched with water (30 mL), acidified with 10% citric acid to pH 4-5, then extracted with n-butanol (3x). Org. layers are combined, dried over MgSO ₄ , filtered and evaporated to give a crude orange oil which is still containing some salts. The mixture is suspended in DCM and salts are filtered off. The filtrate is concentrated and the residue is purified by FC CombiFlash (12 g RediSep column, 10-100% EA in hept). The intermediate alcohol is isolated as a yellow oil.

LCMS (A): t _R = 0.49 min; [M+H]+ = 220.3

Step 2: 4-(trifluoromethyl)pyrimidine-5-carbaldehyde

Above alcohol (365 mg, 2.05 mmol, 1 eq) is dissolved in DCM (15 mL) and activated manganese(IV) oxide, (3001 mg, 29.3 mmol, 14.32 eq) is added at rt. The mixture is stirred at rt o/n. The mixture is filtered over a glass-fibre filter and the filtrate is evaporated to give the title aldehyde as a yellow oil.

Step 3: (1S,2S)-2-(((4-(trifluoromethyl)pyrimidin-5-yl)methyl)amino) cyclohexan-1-ol

(1S,2S)-2-Aminocyclohexanol (150 mg, 1.26 mmol, 1 eq) and above aldehyde (245 mg, 1.39 mmol, 1.1 eq) are dissolved in DCM/MeOH 4/1 (5 mL) and sodium cyanoborohydride (100 mg, 1.52 mmol, 1.2 eq) is added portionwise at rt. The mixture is stirred at rt for 3 h. The mixture is diluted with DCM and carefully quenched with water. The mixture is basified with 25% NH ₄ OH solution and the layers are separated (phase separator). The organic layer is concentrated and the crude is purified by FC (CombiFlash, 4 g RediSep column, 0-10% MeOH in EA) to give the title intermediate as a yellow oil.

LCMS (A): t _R = 0.46 min; [M+H]+ = 276.27

Intermediate 54: rac-N-((1R*,2R*)-2-((tert-butyldimethylsilyl)oxy)cyclohexyl) -3,4-difluoroaniline

Step 1 : rac-(1R*,2R*)-2-((3,4-difluorophenyl)amino)cyclohexan-1-ol Cyclohexene oxide (0.258 mL, 2.5 mmol, 1 eq) and 3,4-difluoroaniline (391 mg, 3 mmol, 1.2 eq) are mixed with water (4 mL) and heated at 90°C o/n. The mixture is diluted with water and EA and the org. phase is dried over MgSO ₄ and concentrated. The product is purified by FC (hept/EA 4: 1-1 : 1) to give the desired aminoalcohol as a brownish oil.

LCMS (A): t _R = 0.71 min; [M+H]+ = 228.24 Step 2: rac-N-((1R*,2R*)-2-((tert-butyldimethylsilyl)oxy)cyclohexyl) -3,4-difluoroaniline

To a solution of intermediate of step 1 (320 mg, 1.41 mmol, 1 eq) and 2,6-lutidine (0.328 mL, 2.82 mmol, 2 eq) in DCM dry (14.1 mL) is dropwise added tert-butyldimethylsilyl trifluoromethanesulphonate (0.485 mL, 2.11 mmol, 1.5 eq) at 0°C for 5 min. The mixture is diluted with 10 mL water. The layers are separated (phase separator) and the aq. phase is re-extracted twice with 5 mL DCM. The org. layer is evaporated and dried at hv o/n. The crude is purified by FC (CombiFlash, 12 g Redi-Sep column, 0-50% EA in hept) to give the desired intermediate as an orange oil.

LCMS (A): t _R = 1.27 min; [M+H]+ = 34200

Following compounds are prepared in analogy to Intermediate 54, steps 1 and 2.

Intermediate 98: Methyl (4aR,6R,7R,8R,8aR)-7-hydroxy-2,2-dimethyl-8-(4-(3,4,5-triflu orophenyl)-1H-1,2,3-triazol-1- yl)hexahydropyrano[3,2-d][1,3]dioxine-6-carboxylate

To a solution of the intermediate 5a (120 mg 0.279 mmol, 1 eq) in DMF (2.4 ml) is added NaH (60% dispersion in mineral oil, 11 .3 mg, 0.282 mmol) at 0°C. The reaction mixture is stirred for 0.5 h at rt. Dimethyl sulfate (0.029 ml, 0.307 mmol) is added and the reaction mixture is stirred for 1 hour at rt. The mixture is cooled and quenched with water, extracted twice with ethyl acetate. The combined org. layers are washed with aq. sat. NaCI solution (10 ml), dried with MgSO ₄ and evaporated. The product is purified by CombiFlash, 24 g RediSep column, 0 - 100% ethyl acetate in hexane. The product is isolated as a colourless solid. LCMS (A): t _R = 0.88 min; [M+H]+ = 444.20.

Intermediate 99: Methyl (4aR,6R,7R,8R,8aR)-7-(2-(tert-butoxy)-2-oxoethoxy)-2,2-dimet hyl-8-(4-(3,4,5- tri fluorophenyl)-1H-1,2, 3-triazol-1-yl)hexahydropyrano[3,2-d][1,3]dioxine-6-carboxyl ate

To a solution of intermediate 98 (650 mg, 1.47 mmol, 1 eq) in DMF (15 ml) is added at rt tert-butyl bromoacetate (409 mg, 2.05 mml) and NaH (60% dispersion in mineral oil, 78 mg, 2.05 mmol). The reaction mixture is stirred for 2.5 h at rt. The mixture is cooled and quenched with water, extracted twice with ethyl acetate. The combined org. layers are washed with aq. sat. NaCI solution (10 ml), dried with MgSO ₄ and evaporated. The product is purified by CombiFlash, 24 g RediSep column, 0 - 100% ethyl acetate in hexane. The product is isolated as a colourless solid. LCMS (A): t _R = 1.05 min; [M+H]+ = 558.01.

Intermediate 100a: (4aR,6R,7R,8R,8aR)-7-(2-(tert-butoxy)-2-oxoethoxy)-2,2-dimet hyl-8-(4-(3,4,5- trifluorophenyl)-1H-1,2,3-triazol-1-yl)hexahydropyrano[3,2-d ][1,3]dioxine-6-carboxylic acid

To a solution of intermediate 99 (673 mg, 1.21 mmol, 1 eq) in THF, MeOH, H ₂ O (21 ml, 3:2:1) is added at 0°C LiOH (44 mg, 1.81 mmol) and the mixture is stirred 1 h. Additional LiOH (44 mg, 1.81 mmol) is added and the mixture is stirred for 0.5 h. 1 N aq. HCI is added to maintain pH 4 and the mixture is extracted twice with ethyl acetate. The combined org. layers are washed with aq. sat. NaCI solution (10 ml), dried with MgSO ₄ and evaporated. The product is isolated as a colourless solid. LCMS (A): t _R = 0.96 min; [M+H]+ = 543.99.

Intermediate 100b: (4aR,6R,7R,8R,8aR)-7-(2-(tert-butoxy)-2-oxoethoxy)-8-(4-(2,3 -difluoro-4-methylphenyl)-1H- 1,2,3-triazol-1-yl)-2,2-dimethylhexahydropyrano[3,2-d][1,3]d ioxine-6-carboxylic acid

This compound is prepared in analogy to intermediate 100a from the corresponding acid.

Intermediate 101 : Tert-butyl 2-(((4aR,6R,7R,8R,8aR)-6-(((1S,2S)-2-((tert-butyldimethylsil yl)oxy)cyclohexyl)(3,5- dichlorophenyl)carbamoyl)-2, 2-dimethyl-8-(4-(3, 4, 5-tri fluorophenyl)-1H-1, 2, 3-triazol-1- yl)hexahydropyrano[3,2-d][1,3]dioxin-7-yl)oxy)acetate

The compound is prepared from the intermediate 100a and intermediate 56 according to the general procedure B. LCMS (A): t _R = 1.43 min; [M+H]+ = 899.17. Intermediate 102: Tert-butyl 2-(((2R,3R,4S,5R,6R)-2-((3,5-dichlorophenyl)((1S,2S)-2- hydroxycyclohexyl)carbamoyl)-5-hydroxy-6-(hydroxymethyl)-4-( 4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1- yl)tetrahydro-2H-pyran-3-yl)oxy)acetate

To a solution of intermediate 101 (450 mg, 0.50 mmol) in 1,4-dioxane (24 ml) and water (12 ml) is added at 0°C dropwise TFA (3.1 ml). The reaction mixture is stirred at rt for 16 h. Sat. aq. NaHCO ₃ is added to maintain pH 8 and the mixture is extracted twice with ethyl acetate. The combined org. layers are washed with aq. sat. NaCI solution (10 ml), dried with MgSO ₄ and evaporated. The product is isolated as a yellowish oil. LCMS (A): t _R = 1.10 min; [M+H]+ = 745.19.

The following intermediated are prepared in 2 steps procedure from corresponding starting materials in analogy to acid 6a.

B- Preparation of examples

General procedure A: Amide coupling with T3P

To a solution of acid component (1 eq) and amine intermediate (1.1 eq) in DMF (5 mL/mmol) is added DIPEA (1.5 eq) and T3P (50% solution in EA, 1.5 eq) and the mixture is stirred at rt until complete conversion. After aqueous workup (EA/dil HCI) the products are purified as described in the general methods.

General procedure B: Amide coupling with POCI ₃ /pyridine

To a solution of acid component (1 eq) and amine intermediate (1.2 eq) in DCM (10 mL/mmol) at 0°C is dropwise added phosphorus(V) oxychloride (1 M solution in pyridine, 0.451 mL, 0.451 mmol, 1 eq) within 2-3 min. The mixture is stirred at 0°C for 10 min and then allowed to slowly warm to rt. After completion of the reaction, the mixture is quenched with 10% citric acid and extracted twice with EA. The org. layers are washed with brine. The combined org. layers are dried over magnesium sulfate, filtered and concentrated. The products are purified as described in the general methods.

General procedure C: Deprotection with aq AcOH

The protected intermediate (acetal and/or silyl Pg) (1eq) is refluxed in AcOH/ H ₂ O 1:1 (5 mL/mmol) until completion of reaction. The products are purified as described in the general methods.

General procedure D: Deprotection with CSA in MeOH

CSA (0.1 eq) is added to the isopropylidene protected intermediate (1 eq) in MeOH (5 mL/mmol) and heated at reflux until completion of reaction. The products are purified as described in the general methods.

General procedure E: Acetate deprotection with K ₂ CO ₃ in MeOH K ₂ CO ₃ (0.1 eq) is added to the acetate protected intermediate (1 eq) in MeOH (5 mL/mmol) and stirred at rt until completion of reaction. The products are purified as described in the general methods. Compounds of Examples listed in Table 1 below are prepared by applying either one of the above-mentioned procedures A or B in the coupling with acids 1-9, 98-128 and amines 10-97, 129-133. The final compounds are obtained by deprotection using procedures C, D or E. Table 1 :

Example 195: 2-(((2R,3R,4S,5R,6R)-2-((3,5-dichlorophenyl)((1S,2S)-2-hydro xycyclohexyl)carbamoyl)-5- hydroxy-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl)-1H-1, 2,3-triazol-1-yl)tetrahydro-2H-pyran-3- yl)oxy)acetic acid To a solution of intermediate 102 (373 mg, 0.5 mmol, 1 eq) in DCM (3 ml) is added at rt 2M TFA (1.20 ml) and the reaction mixture is stirred at rt for 3 h. The solvent is evaporated. The product is isolated as a TFA salt. LCMS (A): tR = 0.90 min; [M+H]+ = 689.18.

Example 196: (2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-5-hydroxy-N-((1S,2S) -2-hydroxycyclohexyl)-3-(2- hydroxyethoxy)-6-(hydroxymethyl)-4-(4-(3,4,5-trifluorophenyl )-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2- carboxamide

To a solution of example 195 (54 mg, 0.067 mmol, 1 eq) in THF (3 ml) is added at 0°C 2M solution of BH ₃ .Me ₂ S in THF (0.14 ml, 4.2 eq) and the reaction mixture is stirred at rt for 24 h. MeOH (1 ml) and aq. sat. NH ₄ CI solution (15 ml) is added and the mixture is extracted twice with ethyl acetate. The combined org. layers are washed with aq. sat. NaCI solution (10 ml) are evaporated. The product is purified by LC-MS (I). The product is isolated as a colourless solid. LCMS (A): t _R = 0.90 min; [M+H]+ = 689.17. Example 124: (2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-5-hydroxy-N-((1S,2S) -2-hydroxycyclohexyl)-6-

(hydroxymethyl)-3-(2-morpholino-2-oxoethoxy)-4-(4-(3,4,5- trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H- pyran-2-carboxamide

To a solution of example 195 (50 mg, 0.049 mmol, 1 eq) in DMF (1 ml) is added at rt HATU (0.040 ml, 2 eq), morpholine (9 mI, 2 eq) and DIPEA (42 mI, 5 eq) and the reaction mixture is stirred at rt for 0.5 h. The reaction mixture is purified by LC-MS (I). The product is isolated as a colourless solid. LCMS (A): tR = 0.95 min; [M+H]+ = 757.99.

Following compounds are prepared in analogy to example 124 from the example 195 and the corresponding amine.

Example 125: (2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-5-hydroxy-N-((1S,2S) -2-hydroxycyclohexyl)-6-

(hydroxymethyl)-3-(2-((S)-3-hydroxypyrrolidin-1-yl)-2-oxo ethoxy)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol- 1-yl)tetrahydro-2H-pyran-2-carboxamide

LCMS (A): t _R = 0.86 min; [M+H]+ = 758.19.

Example 126: (2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-5-hydroxy-N-((1S,2S) -2-hydroxycyclohexyl)-6-

(hydroxymethyl)-3-(2-((R)-3-hydroxypyrrolidin-1-yl)-2-oxo ethoxy)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol- 1-yl)tetrahydro-2H-pyran-2-carboxamide

LCMS (A): t _R = 0.86 min; [M+H]+ = 758.18.

Example 127: (2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-5-hydroxy-N-((1S,2S) -2-hydroxycyclohexyl)-6-

(hydroxymethyl)-3-(2-(4-hydroxypiperidin-1-yl)-2-oxoethox y)-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1- yl)tetrahydro-2H-pyran-2-carboxamide

Step 1 :(2R,3R,4S,5R,6R)-3-(2-(4-((tert-butyldimethylsilyl)oxy)pipe ridin-1-yl)-2-oxoethoxy)-N-(3,5-dichlorophenyl)-5- hydroxy-N-((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-4- (4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1- yl)tetrahydro-2H-pyran-2-carboxamide is prepared from example 195 and 4-((tert-butyldimethylsilyl)oxy)piperidine according to the procedure described for example 124.

LCMS (A): t _R = 1 .23 min; [M+H]+ = 886.36.

Step 2:To the solution of the silyl ether described above (28 mg, 0.032 mmol) in dioxan (3 ml) and water (1.45 ml) is added TFA (0.4 ml) and the reaction mixture is stirred at rt for 1.5 h. Ethyl acetate (10 ml) and aq. sat. NaHCO ₃ solution (15 ml) is added to maintain the pH 8, the water phase is separated and extracted twice with ethyl acetate. The combined org. layers are evaporated. The product is purified by LC-MS (I). The product is isolated as a colourless solid. LCMS (A): t _R = 0.88 min; [M+H]+ = 772.17.

Example 128: (2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-5-hydroxy-3-(2-(3-hy droxyazetidin-1-yl)-2-oxoethoxy)-

N-((1S,2S)-2-hydroxycyclohexyl)-6-(hydroxymethyl)-4-(4-(3 ,4,5-trifluorophenyl)-1H-1,2,3-triazol-1- yl)tetrahydro-2H-pyran-2-carboxamide This compound is prepared in 2 steps procedure in analogy to example 127. LCMS (A): tR = 0.85 min; [M+H]+ = 744.09.

Example 203: (2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-4-(4-(3,5-difluoro-4 -morpholinophenyl)-1H-1,2,3-triazol-

1-yl)-5-hydroxy-N-((1S,2S)-2-hydroxycyclohexyl)-6-(hydrox ymethyl)-3-methoxytetrahydro-2H-pyran-2- carboxamide

Stepl : To a solution of the intermediate 6a ((0.100 mg, 0.226 mmol, 1 eq) , K2CO3 (0.156 mg, 1.13 mmol) in DMSO (4ml) is added at rt morpholine (0.100 ml, 1.13 mmol) and the reaction mixture is stirred at 130°C for 40 h. Morpholine (0.100 ml) is added and mixture is stirred for 5 days. Ethyl acetate and aq. sat. NaH4CI solution is added to maintain the pH 6-7, the water phase is separated and extracted twice with ethyl acetate. The combined org. layers are evaporated. The product is purified by LC-MS (I). The product is isolated as a colourless solid. LCMS (A): tR = 0.86 min; [M+H]+ = 511.03.

Step 2: The amide coupling of the acid from step 1 with the amine 56 is performed according to the procedure B. LCMS (A): tR = 1.42 min; [M+H]+ = 866.09.

Step 3: The product from step 2 is deprotected according to the procedure described for example 127, step 2.

LCMS (A): tR = 1 .00 min; [M+H]+ = 712.03.

Example 204: (2R,3R,4S,5R,6R)-N-(3,5-dichlorophenyl)-4-(4-(3,5-difluoro-4 -((3-hydroxypropyl)amino)phenyl)-

1H-1,2,3-triazol-1-yl)-5-hydroxy-N-((1S,2S)-2-hydroxycycl ohexyl)-6-(hydroxymethyl)-3-methoxytetrahydro-2H- pyran-2-carboxamide

Example 204 is prepared in analogy to example 203 using azetidine instead of morpholine in step 1.

LCMS (A): tR = 0.93 min; [M+H]+ = 700.01.

II. Biological Assays

Evaluation of compound inhibitory activity (IC50)

The inhibitory activity of compounds is determined in competitive binding assays. This spectrophotometric assay measures the binding of biotinylated human Gal-3 (hGal-3) or human Gal-1 (hGal-1), respectively, to a microplate- adsorbed glycoprotein, asialofetuin (ASF) (Proc Natl Acad Sci U S A. 2013 Mar 26; 110(13):5052-7.). Alternatively, and preferably, a human Gal-1 version in which all six cysteines are substituted by serines may be used.

Briefly, compounds are serially diluted in DMSO (working dilutions). ASF-coated 384well plates are supplemented with 22.8 mL/well of biotinylated hGal-3 or hGal-1 in assay buffer (i.e. 300-1000 ng/mL biotinylated hGal-3 or hGal-1) to which 1.2 mL of compound working dilutions are added and mixed. Plates are incubated for 3 hours at 4°C, then washed with cold assay buffer (3x50uL), incubated for 1 hour with 25 mL/well of a streptavidin-peroxidase solution (diluted in assay buffer to 80 ng/mL) at 4°C, followed by further washing steps with assay buffer (3x50uL). Finally, 25 mL /well of ABTS substrate is added. OD (410nm) is recorded after 30 to 45min and values are calculated. The calculated IC ₅₀ values may fluctuate depending on the daily assay performance. Fluctuations of this kind are known to those skilled in the art. IC ₅₀ values from several measurements are given as mean values.

Table 2 - Activity on hGal-3 (IC ₅₀ in mM): Table 3 - Activity on hGal-1 (IC ₅₀ in mM):